The metabolic regulation of aging (Q38662555)

5 September 2017

The metabolic regulation of aging (English)

1 reference

5 September 2017

Toren Finkel

1

1 reference

PubMed ID

26646498

5 September 2017

language of work or name

English

0 references

publication date

1 December 2015

1 reference

5 September 2017

1 reference

5 September 2017

21

1 reference

5 September 2017

1416-1423

1 reference

5 September 2017

12

1 reference

https://scigraph.springernature.com/pub.10.1038/nm.3998

5 September 2017

0 references

cites work

Aging, longevity, and diet: historical remarks on calorie intake reduction

1 reference

Promoting health and longevity through diet: from model organisms to humans

21 January 2018

1 reference

Rates of behavior and aging specified by mitochondrial function during development

21 January 2018

1 reference

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

21 January 2018

1 reference

Premature ageing in mice expressing defective mitochondrial DNA polymerase

21 January 2018

1 reference

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

21 January 2018

1 reference

Tipping the metabolic scales towards increased longevity in mammals

21 January 2018

1 reference

21 January 2018

1 reference

Dwarf mice and the ageing process.

21 January 2018

1 reference

Extending the lifespan of long-lived mice

21 January 2018

1 reference

Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial

21 January 2018

1 reference

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity

21 January 2018

1 reference

Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.

21 January 2018

1 reference

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

21 January 2018

1 reference

Fat maintenance is a predictor of the murine lifespan response to dietary restriction

21 January 2018

1 reference

Metabolic mass, metabolic rate, caloric restriction, and aging in male Fischer 344 rats.

21 January 2018

1 reference

Metabolic characteristics of long-lived mice

21 January 2018

1 reference

Effect of aging on muscle mitochondrial substrate utilization in humans

21 January 2018

1 reference

Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial

21 January 2018

1 reference

Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques

21 January 2018

1 reference

Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution

21 January 2018

1 reference

Overview of caloric restriction and ageing

21 January 2018

1 reference

Caloric restriction delays disease onset and mortality in rhesus monkeys

21 January 2018

1 reference

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

21 January 2018

1 reference

mTOR signaling in cellular and organismal energetics

21 January 2018

1 reference

Genetics: influence of TOR kinase on lifespan in C. elegans

21 January 2018

1 reference

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

1 reference

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

21 January 2018

1 reference

Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression

21 January 2018

1 reference

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

21 January 2018

1 reference

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

21 January 2018

1 reference

mTOR is a key modulator of ageing and age-related disease

21 January 2018

1 reference

FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

21 January 2018

1 reference

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

21 January 2018

1 reference

Direct control of mitochondrial function by mTOR.

21 January 2018

1 reference

Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression

21 January 2018

1 reference

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

21 January 2018

1 reference

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

21 January 2018

1 reference

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.

21 January 2018

1 reference

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

21 January 2018

1 reference

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

21 January 2018

1 reference

Sir2-independent life span extension by calorie restriction in yeast

21 January 2018

1 reference

Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.

21 January 2018

1 reference

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

1 reference

Tissue-specific regulation of SIRT1 by calorie restriction

21 January 2018

1 reference

SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice.

21 January 2018

1 reference

Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.

21 January 2018

1 reference

The sirtuin SIRT6 regulates lifespan in male mice

21 January 2018

1 reference

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

21 January 2018

1 reference

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

21 January 2018

1 reference

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

21 January 2018

1 reference

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

21 January 2018

1 reference

Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome

21 January 2018

1 reference

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

21 January 2018

1 reference

A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3.

21 January 2018

1 reference

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

21 January 2018

1 reference

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

21 January 2018

1 reference

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

21 January 2018

1 reference

Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies.

21 January 2018

1 reference

AMPK at the nexus of energetics and aging.

21 January 2018

1 reference

Calorie restriction: is AMPK a key sensor and effector?

21 January 2018

1 reference

AMPK modulates tissue and organismal aging in a non-cell-autonomous manner

21 January 2018

1 reference

Autophagy genes are essential for dauer development and life-span extension in C. elegans

21 January 2018

1 reference

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

21 January 2018

1 reference

Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification

21 January 2018

1 reference

Overexpression of Atg5 in mice activates autophagy and extends lifespan

21 January 2018

1 reference

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

21 January 2018

1 reference

A C. elegans mutant that lives twice as long as wild type

21 January 2018

1 reference

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

21 January 2018

1 reference

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

21 January 2018

1 reference

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

21 January 2018

1 reference

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

21 January 2018

1 reference

Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation

21 January 2018

1 reference

Brain IRS2 signaling coordinates life span and nutrient homeostasis

21 January 2018

1 reference

Functionally significant insulin-like growth factor I receptor mutations in centenarians

21 January 2018

1 reference

Genetics and genomics of human ageing

21 January 2018

1 reference

The somatotropic axis and longevity in mice

21 January 2018

1 reference

Essential role for autophagy in life span extension

21 January 2018

1 reference

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

21 January 2018

1 reference

Decline in skeletal muscle mitochondrial function with aging in humans

21 January 2018

1 reference

Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans

21 January 2018

1 reference

Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

21 January 2018

1 reference

Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans

21 January 2018

1 reference

Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity

21 January 2018

1 reference

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans

21 January 2018

1 reference

p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress.

21 January 2018

1 reference

The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans

21 January 2018

1 reference

The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans

21 January 2018

1 reference

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

21 January 2018

1 reference

Oxidative stress response and Nrf2 signaling in aging

21 January 2018

1 reference

Mitochondrial SKN-1/Nrf mediates a conserved starvation response

21 January 2018

1 reference

Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension

21 January 2018

1 reference

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

21 January 2018

1 reference

Aging: a theory based on free radical and radiation chemistry

21 January 2018

1 reference

The mitochondrial free radical theory of aging

21 January 2018

1 reference

21 January 2018

1 reference

Unraveling the truth about antioxidants: mitohormesis explains ROS-induced health benefits

21 January 2018

1 reference

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS).

21 January 2018

1 reference

The cell-non-autonomous nature of electron transport chain-mediated longevity

21 January 2018

1 reference

Muscle mitohormesis promotes longevity via systemic repression of insulin signaling

21 January 2018

1 reference

The mitochondrial unfolded protein response—synchronizing genomes

21 January 2018

1 reference

Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.

21 January 2018

1 reference

Caenorhabditis elegans pathways that surveil and defend mitochondria

21 January 2018

1 reference

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

21 January 2018

1 reference

Mitonuclear protein imbalance as a conserved longevity mechanism

21 January 2018

1 reference

Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

21 January 2018

1 reference

Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction

21 January 2018

1 reference

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

21 January 2018

1 reference

Autophagy and aging: the importance of maintaining "clean" cells

21 January 2018

1 reference

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

21 January 2018

1 reference

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

21 January 2018

1 reference

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

1 reference

The controversial world of sirtuins

21 January 2018

1 reference

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 January 2018

1 reference

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

21 January 2018

1 reference

Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.

21 January 2018

1 reference

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.

21 January 2018

1 reference

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

21 January 2018

1 reference

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet

21 January 2018

1 reference

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

21 January 2018

1 reference

Metformin improves healthspan and lifespan in mice

21 January 2018

1 reference

Induction of autophagy by spermidine promotes longevity

21 January 2018

1 reference

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

21 January 2018

1 reference

NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

21 January 2018

1 reference

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

21 January 2018

1 reference

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

21 January 2018

1 reference

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

21 January 2018

1 reference

NAD+ and sirtuins in aging and disease

21 January 2018

1 reference

Methusaleh's Zoo: how nature provides us with clues for extending human health span

21 January 2018

1 reference

High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice

21 January 2018

1 reference

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.

21 January 2018

1 reference

Chinese agriculture: An experiment for the world

21 January 2018

1 reference

Changes in adipose mass and cellularity through the adult life of rats fed ad libitum or a life-prolonging restricted diet

21 January 2018

1 reference

7 January 2021

Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition

1 reference

7 January 2021

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

1 reference

7 January 2021

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

1 reference

7 January 2021

Loss of pregnancy-associated plasma protein A extends lifespan in mice

1 reference

7 January 2021

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

1 reference

7 January 2021

Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice

1 reference

7 January 2021

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM.3998

1 reference

PubMed ID

26646498

Dimensions Publication ID

5 September 2017

0 references

1 reference

PubMed ID

26646498