T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis (Q38650724)

5 September 2017

T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis (English)

1 reference

5 September 2017

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2

1 reference

5 September 2017

Patrick Blanco

1

1 reference

PubMed ID

26614103

5 September 2017

Nathalie Schmitt

series ordinal

3

1 reference

PubMed ID

26614103

5 September 2017

language of work or name

English

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publication date

28 November 2015

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European Journal of Immunology

5 September 2017

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5 September 2017

46

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5 September 2017

2

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5 September 2017

281-290

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Systemic lupus erythematosus.

5 September 2017

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Persistent expression of autoantibodies in SLE patients in remission

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Defective B cell tolerance checkpoints in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Autoreactivity in human IgG+ memory B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

How T cells earn the follicular rite of passage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

The origins, function, and regulation of T follicular helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

T follicular helper cell differentiation, function, and roles in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Pathophysiology of T follicular helper cells in humans and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Harnessing human dendritic cell subsets for medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Genetic susceptibility to systemic lupus erythematosus in the genomic era

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Dendritic cells and cytokines in human inflammatory and autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

The role of dendritic cells in autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Interferon and granulopoiesis signatures in systemic lupus erythematosus blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Type I IFN system in the development and manifestations of SLE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

The combination of apoptotic U937 cells and lupus IgG is a potent IFN-alpha inducer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Systemic lupus erythematosus and the type I interferon system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Development of TLR inhibitors for the treatment of autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Cutting edge: dissociation between autoimmune response and clinical disease after vaccination with dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Tolerogenic function of Blimp-1 in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

The BAFF/APRIL system in SLE pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

T follicular helper cell dynamics in germinal centers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Extrafollicular antibody responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Follicular helper T cells are required for systemic autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Phenotype and functions of memory Tfh cells in human blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Circulating TFH subset distribution is strongly affected in lupus patients with an active disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Role of the frequency of blood CD4(+) CXCR5(+) CCR6(+) T cells in autoimmunity in patients with Sjögren's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Constitutively altered frequencies of circulating follicullar helper T cell counterparts and their subsets in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Bcl6 mediates the development of T follicular helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Development and characterization of IL-21-producing CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Human 6-sulfo LacNAc (slan) dendritic cells have molecular and functional features of an important pro-inflammatory cell type in lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Control of immunity by the TNFR-related molecule OX40 (CD134)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

A polymorphism within IL21R confers risk for systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

IRF8 mutations and human dendritic-cell immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

IFN priming is necessary but not sufficient to turn on a migratory dendritic cell program in lupus monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Efficacy and safety of abatacept in lupus nephritis: a twelve-month, randomized, double-blind study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

T cells as therapeutic targets in SLE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

FOXP3+ regulatory T cells in the human immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

T cells as a therapeutic target in SLE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

STAT5 is a potent negative regulator of TFH cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

T follicular regulatory cells in the regulation of B cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

IFN- Production by Plasmacytoid Dendritic Cells Stimulated with RNA-Containing Immune Complexes Is Promoted by NK Cells via MIP-1 and LFA-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

On the Pathology of Lupus Erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

7 January 2021

Phenotype and function of dendritic cells of patients with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

7 January 2021

Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

7 January 2021

Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

7 January 2021

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

7 January 2021

Serum cytokine profile in patients with active lupus nephritis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

7 January 2021

Overexpression of interleukin-12 and T helper 1 predominance in lupus nephritis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

7 January 2021

The association of interleukin-21 polymorphisms with interleukin-21 serum levels and risk of systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

7 January 2021

A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

7 January 2021

Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545760

7 January 2021

Identifiers

DOI

10.1002/EJI.201545760

1 reference

5 September 2017

1 reference

PubMed ID

26614103