IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses (Q33656146)

28 July 2017

title

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses (English)

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28 July 2017

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1

Michelle A Linterman

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28 July 2017

Robert J Rigby

9

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Naresh Verma

Naresh K Verma

7

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Di Yu

Di Yu

3

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Carola Garcia de Vinuesa

Carola G Vinuesa

10

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Mark J. Smyth

Mark J Smyth

8

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author name string

Laura Beaton

2

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28 July 2017

Roybel R Ramiscal

4

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28 July 2017

Monika Srivastava

5

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28 July 2017

Jennifer J Hogan

6

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28 July 2017

publication date

8 February 2010

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Journal of Experimental Medicine

28 July 2017

language of work or name

English

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published in

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28 July 2017

volume

207

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28 July 2017

issue

2

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28 July 2017

page(s)

353-363

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New insights into the regulation of T cells by gamma(c) family cytokines

28 July 2017

cites work

1 reference

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The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

28 July 2018

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Follicular helper T cells are required for systemic autoimmunity

28 July 2018

1 reference

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Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS

28 July 2018

1 reference

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The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

28 July 2018

1 reference

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ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

28 July 2018

1 reference

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The role of IL-21 in regulating B-cell function in health and disease.

28 July 2018

1 reference

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A fundamental role for interleukin-21 in the generation of T follicular helper cells

28 July 2018

1 reference

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

28 July 2018

1 reference

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Vaccine adjuvants alter TCR-based selection thresholds.

28 July 2018

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Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

28 July 2018

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Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration

28 July 2018

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Germinal-center organization and cellular dynamics

28 July 2018

1 reference

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

28 July 2018

1 reference

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

28 July 2018

1 reference

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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

28 July 2018

1 reference

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IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production

28 July 2018

1 reference

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Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

28 July 2018

1 reference

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IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells

28 July 2018

1 reference

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Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization.

28 July 2018

1 reference

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Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6

28 July 2018

1 reference

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T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

28 July 2018

1 reference

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Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells

28 July 2018

1 reference

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Extrafollicular antibody responses

28 July 2018

1 reference

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B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822609

A critical role for IL-21 in regulating immunoglobulin production

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822609

Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822609

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822609

The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822609

In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines

28 July 2018

1 reference

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Control of inflammation, cytokine expression, and germinal center formation by BCL-6

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822609

Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822609

Salmonella dublin experimental infection in calves: protection after oral immunization with an auxotrophic aroA live vaccine.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822609

IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4.

28 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091738

Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091738

Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091738

Two waves of memory B-cell generation in the primary immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091738

Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091738

Bcl6 mediates the development of T follicular helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091738

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091738

Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091738

IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091738

Salmonella-induced apoptosis of infected macrophages results in presentation of a bacteria-encoded antigen after uptake by bystander dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091738

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091738

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

21 January 2018

1 reference

12 December 2020

Effect of Toxoplasma gondii on histopathology and histochemistry or reticuloendothelial system in experimental animals

1 reference

12 December 2020

IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells

1 reference

12 December 2020

Cutting Edge: IL-21 Is Not Essential for Th17 Differentiation or Experimental Autoimmune Encephalomyelitis

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20091738

1 reference

28 July 2017

1 reference

28 July 2017

1 reference