Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions (Q38615371)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28827538%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

title

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28827538%20AND%20SRC:MED&resulttype=core&format=json

G protein-coupled receptor 61

28 March 2020

main subject

melatonin

0 references

1 reference

G protein-coupled receptor 135

1 reference

G protein-coupled receptor 62

1 reference

arrestin family protein binding

1 reference

author

Atsuro Oishi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28827538%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

Angeliki Karamitri

2

1 reference

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28 March 2020

Romain Gerbier

3

1 reference

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28 March 2020

Olivier Lahuna

4

1 reference

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28 March 2020

Raise Ahmad

5

1 reference

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28 March 2020

author name string

Ralf Jockers

6

1 reference

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28 March 2020

language of work or name

English

0 references

publication date

21 August 2017

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28 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28827538%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

volume

7

1 reference

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28 March 2020

page(s)

8990

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28 March 2020

issue

1

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Creative Commons Attribution 4.0 International

28 March 2020

copyright license

start time

21 August 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/s41598-017-08996-7

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cites work

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Functional competence of a partially engaged GPCR-β-arrestin complex

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Update on melatonin receptors: IUPHAR Review 20.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

The G protein-coupled receptor GPR157 regulates neuronal differentiation of radial glial progenitors through the Gq-IP3 pathway

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Constitutive Activity among Orphan Class-A G Protein Coupled Receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Propagation of conformational changes during μ-opioid receptor activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Altered placental DNA methylation patterns associated with maternal smoking: current perspectives

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Visualization of arrestin recruitment by a G-protein-coupled receptor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Molecular evolution of GPCRs: Ghrelin/ghrelin receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Cold-induced changes in gene expression in brown adipose tissue, white adipose tissue and liver

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

G protein-coupled receptor deorphanizations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Regulation of RhoA signaling by the cAMP-dependent phosphorylation of RhoGDIα

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Heteromerization of human cytomegalovirus encoded chemokine receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Therapeutic potential of β-arrestin- and G protein-biased agonists.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

The structure and function of G-protein-coupled receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Anatomical profiling of G protein-coupled receptor expression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

The G protein-coupled receptor subset of the rat genome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization

6 September 2017

1 reference

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6 September 2017

1 reference

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6 September 2017

1 reference

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6 September 2017

1 reference

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6 September 2017

1 reference

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6 September 2017

1 reference

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6 September 2017

1 reference

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6 September 2017

1 reference

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On the existence of a possible A2A-D2-β-Arrestin2 complex: A2A agonist modulation of D2 agonist-induced β-arrestin2 recruitment.

6 September 2017

1 reference

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1 reference

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14 September 2017

1 reference

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14 September 2017

1 reference

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14 September 2017

1 reference

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14 September 2017

1 reference

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1 reference

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23 June 2018

1 reference

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Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence

23 June 2018

1 reference

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23 June 2018

1 reference

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Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs.

31 August 2018

1 reference

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A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

The PDZ protein mupp1 promotes Gi coupling and signaling of the Mt1 melatonin receptor

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

Starvation induces cAMP response element-binding protein-dependent gene expression through octopamine-Gq signaling in Caenorhabditis elegans.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5566548

10.1038/S41598-017-08996-7

31 August 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28827538%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

28 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28827538%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference