Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System (Q38612543)

4 September 2017

Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System (English)

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4 September 2017

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2

Kullervo Hynynen

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4 September 2017

Alison Burgess

1

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PubMed ID

26486344

4 September 2017

language of work or name

English

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publication date

1 January 2016

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Advances in Experimental Medicine and Biology

4 September 2017

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4 September 2017

880

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4 September 2017

293-308

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Structure and function of the blood-brain barrier

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Focused ultrasound delivers targeted immune cells to metastatic brain tumors

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Clearance of albumin following ultrasound-induced blood-brain barrier opening is mediated by glial but not neuronal cells.

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Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening.

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Pericytes regulate the blood-brain barrier

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Controlled ultrasound-induced blood-brain barrier disruption using passive acoustic emissions monitoring

31 March 2020

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Multiple treatments with liposomal doxorubicin and ultrasound-induced disruption of blood-tumor and blood-brain barriers improve outcomes in a rat glioma model

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Ultrasonically produced changes in the blood-brain barrier.

31 March 2020

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Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood-brain barrier using focused ultrasound and microbubbles

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Blood-brain barrier (BBB) disruption using a diagnostic ultrasound scanner and Definity in Mice

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Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier

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Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression

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Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior

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The size of blood-brain barrier opening induced by focused ultrasound is dictated by the acoustic pressure

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Novel magnetic/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment

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Blood vessel deformations on microsecond time scales by ultrasonic cavitation.

31 March 2020

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Ultrasound-induced mild hyperthermia as a novel approach to increase drug uptake in brain microvessel endothelial cells

31 March 2020

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Two-photon fluorescence microscopy study of cerebrovascular dynamics in ultrasound-induced blood-brain barrier opening

31 March 2020

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Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice.

31 March 2020

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Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound

31 March 2020

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Microbubble-size dependence of focused ultrasound-induced blood-brain barrier opening in mice in vivo

31 March 2020

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Noninvasive and localized blood-brain barrier disruption using focused ultrasound can be achieved at short pulse lengths and low pulse repetition frequencies

31 March 2020

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The role of internal reflection in transskull phase distortion.

31 March 2020

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Pericytes are required for blood-brain barrier integrity during embryogenesis

31 March 2020

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Ultrasound-induced cell membrane porosity

31 March 2020

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The role of caveolin-1 in blood-brain barrier disruption induced by focused ultrasound combined with microbubbles.

31 March 2020

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Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: potential for targeting experimental brain tumors

31 March 2020

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Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound

31 March 2020

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SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery

31 March 2020

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Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment

31 March 2020

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Structural and Functional Variations in Capillary Systems within the Brain

31 March 2020

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Fundamental neurological research and human neurosurgery using intense ultrasound

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Contrast agent kinetics in the rabbit brain during exposure to therapeutic ultrasound

31 March 2020

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A comparison of postoperative outcomes utilizing a continuous preperitoneal infusion versus epidural for midline laparotomy

31 March 2020

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The blood-brain barrier/neurovascular unit in health and disease

31 March 2020

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A three-dimensional model of an ultrasound contrast agent gas bubble and its mechanical effects on microvessels

31 March 2020

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Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound

31 March 2020

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Demonstration of potential noninvasive ultrasound brain therapy through an intact skull.

31 March 2020

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Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits

31 March 2020

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500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls.

31 March 2020

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Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications

31 March 2020

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Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery

31 March 2020

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Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats

31 March 2020

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Astrocytes induce blood–brain barrier properties in endothelial cells

31 March 2020

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Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease

31 March 2020

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Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

31 March 2020

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Targeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system.

31 March 2020

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Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption

31 March 2020

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Tight junctions of the blood-brain barrier

31 March 2020

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The cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in vascular homeostatis and pathophysiology.

31 March 2020

1 reference

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Enhanced caveolae-mediated endocytosis by diagnostic ultrasound in vitro

31 March 2020

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MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study.

31 March 2020

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Opening of the blood-brain barrier by low-frequency (28-kHz) ultrasound: a novel pinhole-assisted mechanical scanning device.

31 March 2020

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Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment

31 March 2020

1 reference

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Intranasal delivery of biologics to the central nervous system

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Noninvasive, transient and selective blood-brain barrier opening in non-human primates in vivo.

31 March 2020

1 reference

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MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain.

31 March 2020

1 reference

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MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits

31 March 2020

1 reference

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Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activity.

31 March 2020

1 reference

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Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study

31 March 2020

1 reference

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Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index

31 March 2020

1 reference

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Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption

31 March 2020

1 reference

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Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients

31 March 2020

1 reference

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Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques

31 March 2020

1 reference

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Experimental study on targeted methotrexate delivery to the rabbit brain via magnetic resonance imaging-guided focused ultrasound.

31 March 2020

1 reference

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Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation

31 March 2020

1 reference

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High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption

31 March 2020

1 reference

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Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy

31 March 2020

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Biological effects of ultrasound: development of safety guidelines. Part II: general review

31 March 2020

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Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller

31 March 2020

1 reference

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Revisit of combined parallel-beam/cone-beam or fan-beam/cone-beam imaging

31 March 2020

1 reference

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Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate

31 March 2020

1 reference

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The blood-brain barrier: bottleneck in brain drug development

31 March 2020

1 reference

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Drug transport across the blood-brain barrier

31 March 2020

1 reference

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Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier

31 March 2020

1 reference

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Ultrasound-mediated blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model

31 March 2020

1 reference

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Ultrasound and the blood-brain barrier.

31 March 2020

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Intranasal drug delivery: how, why and what for?

31 March 2020

1 reference

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Advances in osmotic opening of the blood-brain barrier to enhance CNS chemotherapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo.

31 March 2020

1 reference

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Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Dependence of the reversibility of focused- ultrasound-induced blood-brain barrier opening on pressure and pulse length in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

A quantitative pressure and microbubble-size dependence study of focused ultrasound-induced blood-brain barrier opening reversibility in vivo using MRI.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Selective Alteration of the Blood-Brain Barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium

31 March 2020

1 reference

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Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound

31 March 2020

1 reference

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Expression and adhesive properties of basement membrane proteins in cerebral capillary endothelial cell cultures

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Shear stress-mediated extracellular signal-regulated kinase activation is regulated by sodium in endothelial cells. Potential role for a voltage-dependent sodium channel.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Transcranial pulsed ultrasound stimulates intact brain circuits.

31 March 2020

1 reference

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Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Permeability dependence study of the focused ultrasound-induced blood-brain barrier opening at distinct pressures and microbubble diameters using DCE-MRI

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Histologic effects of high intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Progress and problems in the application of focused ultrasound for blood-brain barrier disruption

31 March 2020

1 reference

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Targeted delivery of GDNF through the blood-brain barrier by MRI-guided focused ultrasound

31 March 2020

1 reference

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Microbubble type and distribution dependence of focused ultrasound-induced blood-brain barrier opening

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Pulse sequence and timing of contrast-enhanced MRI for assessing blood-brain barrier disruption after transcranial focused ultrasound in the presence of hemorrhage.

31 March 2020

1 reference

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A robust MRI-compatible system to facilitate highly accurate stereotactic administration of therapeutic agents to targets within the brain of a large animal model

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Quantitative evaluation of the use of microbubbles with transcranial focused ultrasound on blood-brain-barrier disruption.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

Reversible blood-brain barrier disruption by repeated transcranial focused ultrasound allows enhanced extravasation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22536-4_16

10.1007/978-3-319-22536-4_16

31 March 2020

Identifiers

DOI

1 reference

4 September 2017

1 reference

PubMed ID

26486344