Natural and Synthetic Flavonoids: Structure-Activity Relationship and Chemotherapeutic Potential for the Treatment of Leukemia (Q38606426)

4 September 2017

Natural and Synthetic Flavonoids: Structure-Activity Relationship and Chemotherapeutic Potential for the Treatment of Leukemia (English)

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4 September 2017

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4 September 2017

José C J M D S Menezes

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José C J M D S Menezes

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Barbora Orlikova

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4 September 2017

Franck Morceau

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4 September 2017

13 October 2015

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Critical Reviews in Food Science and Nutrition

4 September 2017

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4 September 2017

56 Suppl 1

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4 September 2017

S4-S28

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Novel insights into the antiproliferative effects and synergism of quercetin and menadione in human leukemia Jurkat T cells

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Anti-cancer potential of flavonoids: recent trends and future perspectives.

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Isolation from Eucalyptus occidentalis and identification of a new kaempferol derivative that induces apoptosis in human myeloid leukemia cells

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Influence of galangin on HL-60 cell proliferation and survival

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Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations.

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Ethyl acetate extract and its major constituent, isorhamnetin 3-O-rutinoside, from Nitraria retusa leaves, promote apoptosis of human myelogenous erythroleukaemia cells.

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Synthesis and effects on cell viability of flavonols and 3-methyl ether derivatives on human leukemia cells.

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Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells

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Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies

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Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR.

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Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells

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Flavopiridol in chronic lymphocytic leukemia: a concise review

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Effects of flavonoids on cisplatin-induced apoptosis of HL-60 and L1210 leukemia cells

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Synthesis of demethylxanthohumol, a new potent apoptosis-inducing agent from hops

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Ability of prenylflavanones present in hops to induce apoptosis in a human Burkitt lymphoma cell line

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Enhancement of flavonoid ability to cross the blood-brain barrier of rats by co-administration with α-tocopherol.

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The influence of 8-prenylnaringenin on the activity of voltage-gated Kv1.3 potassium channels in human Jurkat T cells.

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Pharmacokinetics and bioavailability of quercetin glycosides in humans

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Modulation of P-glycoprotein-mediated multidrug resistance by flavonoid derivatives and analogues

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Advances in flavonoid research since 1992.

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Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells

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Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα.

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Inhibition of P-glycoprotein by flavonoid derivatives in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells

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Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.

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Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells

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Apigenin decreases cell viability and telomerase activity in human leukemia cell lines

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Flavonoid-induced glutathione depletion: potential implications for cancer treatment

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Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores

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Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling

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Apoptotic effects of chrysin in human cancer cell lines

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Two flavonoids from the leaves of Morus alba induce differentiation of the human promyelocytic leukemia (HL-60) cell line

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Polymethoxyflavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells

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Hydroxylation at C4' or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species

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Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade.

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The anticancer potential of flavonoids isolated from the stem bark of Erythrina suberosa through induction of apoptosis and inhibition of STAT signaling pathway in human leukemia HL-60 cells.

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Methylation suppresses the proteasome-inhibitory function of green tea polyphenols.

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Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells

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Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells

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Cytotoxic and apoptotic effects of prenylflavonoid artonin B in human acute lymphoblastic leukemia cells

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Differentiation therapy of human cancer: basic science and clinical applications

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Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin.

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Flavonoids from Vitex trifolia L. inhibit cell cycle progression at G2/M phase and induce apoptosis in mammalian cancer cells

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Growth inhibitory and apoptosis inducing by effects of total flavonoids from Lysimachia clethroides Duby in human chronic myeloid leukemia K562 cells

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Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids

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Adamantyl arotinoids that inhibit IκB kinase α and IκB kinase β.

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2(+/-)-7,8,3',4',5'-Pentamethoxyflavan induces G2/M phase arrest and apoptosis in HL60 cells.

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Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines.

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Apoptotic events induced by synthetic naphthylchalcones in human acute leukemia cell lines

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Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis

21 January 2018

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Dietary bioflavonoids induce apoptosis in human leukemia cells.

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Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways.

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PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathway

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Anti-leukemic activity of Wattakaka volubilis leaf extract against human myeloid leukemia cell lines

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Structure-activity relationship studies of 5,7-dihydroxyflavones as naturally occurring inhibitors of cell proliferation in human leukemia HL-60 cells

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Methylenedioxy flavonoids: assessment of cytotoxic and anti-cancer potential in human leukemia cells.

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Apoptosis induction of human leukemia U937 cells by 7,8-dihydroxyflavone hydrate through modulation of the Bcl-2 family of proteins and the MAPKs signaling pathway

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Morin, a flavonoid from moraceae, induces apoptosis by induction of BAD protein in human leukemic cells

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In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3.

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Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1

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A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.

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Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells

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III-10, a newly synthesized flavonoid, induced differentiation of human U937 leukemia cells via PKCδ activation.

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Cytotoxic effect of flavonoids on leukemia cells and normal cells of human blood.

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Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling

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Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK.

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Apigenin: a promising molecule for cancer prevention

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Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism

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Therapeutic potential of apigenin, a plant flavonoid, for imatinib-sensitive and resistant chronic myeloid leukemia cells.

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Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation

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Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells

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Modulation of P-glycoprotein-mediated anticancer drug accumulation, cytotoxicity, and ATPase activity by flavonoid interactions.

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Height and breast cancer risk--the bias of self-reported versus measured results. Comments on height and breast cancer risk, Tavani et al., Eur J Cancer 1998, 34, 543-547.

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Structure-activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases.

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Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells

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Enhanced lymphatic transport of bioactive lipids: cell culture study of polymethoxyflavone incorporation into chylomicrons

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Induction of apoptosis in K562 human leukemia cells by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone

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6-C-methyl flavonoids isolated from Pinus densata inhibit the proliferation and promote the apoptosis of the HL-60 human promyelocytic leukaemia cell line

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Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays

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10.1080/10408398.2015.1074532

21 January 2018

Identifiers

DOI

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release_fffirbwonrdcnl6hkabkh3vcnu

4 September 2017

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https://api.fatcat.wiki/v0/release/fffirbwonrdcnl6hkabkh3vcnu

mapped directly with Wikidata item

24 November 2022

based on heuristic

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