Genomic integrity and the ageing brain (Q38606228)

4 September 2017

title

Genomic integrity and the ageing brain (English)

1 reference

4 September 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26462757%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Karl Herrup

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26462757%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

language of work or name

English

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publication date

14 October 2015

1 reference

Nature Reviews Neuroscience

4 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26462757%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26462757%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

issue

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26462757%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

page(s)

672-684

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26462757%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrn4020

4 June 2020

exact match

0 references

cites work

Understanding the odd science of aging

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Functional links between telomeres and proteins of the DNA-damage response

31 March 2020

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The DNA damage response: ten years after

31 March 2020

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Genome maintenance mechanisms for preventing cancer

31 March 2020

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Molecular mechanisms of mammalian global genome nucleotide excision repair.

31 March 2020

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Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo

31 March 2020

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Chromatin structure and DNA damage repair

31 March 2020

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Maintaining genome stability in the nervous system

31 March 2020

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Living on a break: cellular senescence as a DNA-damage response

31 March 2020

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Senescence and apoptosis: dueling or complementary cell fates?

31 March 2020

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DNA damage and repair in Alzheimer's disease

31 March 2020

1 reference

The role of ATM and DNA damage in neurons: upstream and downstream connections.

31 March 2020

1 reference

Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: differential expression and pathological meaning

31 March 2020

1 reference

Cell cycle activation linked to neuronal cell death initiated by DNA damage

31 March 2020

1 reference

Oxidative damage in mild cognitive impairment and early Alzheimer's disease

31 March 2020

1 reference

DNA base excision repair activities in mouse models of Alzheimer's disease

31 March 2020

1 reference

Meiotic recombination in mammals: localization and regulation

31 March 2020

1 reference

The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system

31 March 2020

1 reference

Impaired social recognition memory in recombination activating gene 1-deficient mice

31 March 2020

1 reference

Neurobehavioral changes resulting from recombinase activation gene 1 deletion

31 March 2020

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An inhibitor of DNA recombination blocks memory consolidation, but not reconsolidation, in context fear conditioning.

31 March 2020

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On somatic recombination in the central nervous system of transgenic mice.

31 March 2020

1 reference

Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

31 March 2020

1 reference

Franklin H. Epstein Lecture: Sirtuins, aging, and medicine

31 March 2020

1 reference

SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort.

31 March 2020

1 reference

Mosaic copy number variation in human neurons

31 March 2020

1 reference

Chromosomal variation in neurons of the developing and adult mammalian nervous system

31 March 2020

1 reference

Aneuploid neurons are functionally active and integrated into brain circuitry

31 March 2020

1 reference

Alteration of gene expression by chromosome loss in the postnatal mouse brain.

31 March 2020

1 reference

DNA replication precedes neuronal cell death in Alzheimer's disease.

31 March 2020

1 reference

Constitutional aneuploidy in the normal human brain.

31 March 2020

1 reference

Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease

31 March 2020

1 reference

Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain

31 March 2020

1 reference

Human interphase chromosomes: a review of available molecular cytogenetic technologies.

31 March 2020

1 reference

Neuronal DNA content variation (DCV) with regional and individual differences in the human brain

31 March 2020

1 reference

The variation of aneuploidy frequency in the developing and adult human brain revealed by an interphase FISH study.

31 March 2020

1 reference

Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex.

31 March 2020

1 reference

Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease.

31 March 2020

1 reference

Chromosome-specific accumulation of aneuploidy in the aging mouse brain

31 March 2020

1 reference

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

31 March 2020

1 reference

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

31 March 2020

1 reference

Changes of telomere length with aging.

31 March 2020

1 reference

Dyskeratosis congenita as a disorder of telomere maintenance

31 March 2020

1 reference

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

31 March 2020

1 reference

Telomerase deficiency affects normal brain functions in mice.

31 March 2020

1 reference

Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration

31 March 2020

1 reference

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.

31 March 2020

1 reference

Yeast telomeres exert a position effect on recombination between internal tracts of yeast telomeric DNA

31 March 2020

1 reference

Transcriptional silencing at Saccharomyces telomeres: implications for other organisms

31 March 2020

1 reference

ATM function and telomere stability

31 March 2020

1 reference

The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control

31 March 2020

1 reference

Nijmegen breakage syndrome: consequences of defective DNA double strand break repair

31 March 2020

1 reference

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

31 March 2020

1 reference

ATM and ataxia telangiectasia

31 March 2020

1 reference

Telomere Dysfunction of Lymphocytes in Patients With Alzheimer Disease

31 March 2020

1 reference

Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia.

31 March 2020

1 reference

Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression

31 March 2020

1 reference

Neural mechanisms of ageing and cognitive decline

31 March 2020

1 reference

Xeroderma pigmentosum. Defective DNA repair causes skin cancer and neurodegeneration

31 March 2020

1 reference

DNA repair deficiency and neurological disease

31 March 2020

1 reference

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes

31 March 2020

1 reference

Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.

31 March 2020

1 reference

Synaptic proteome changes in a DNA repair deficient ercc1 mouse model of accelerated aging.

31 March 2020

1 reference

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

31 March 2020

1 reference

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

31 March 2020

1 reference

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

31 March 2020

1 reference

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

31 March 2020

1 reference

Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains.

31 March 2020

1 reference

DNA end joining activity is reduced in Alzheimer's disease

31 March 2020

1 reference

DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease

31 March 2020

1 reference

Regulation of the DNA damage response by cyclin-dependent kinases.

31 March 2020

1 reference

Controlling DNA-end resection: a new task for CDKs

31 March 2020

1 reference

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

31 March 2020

1 reference

DNA damage checkpoints: from initiation to recovery or adaptation

31 March 2020

1 reference

31 March 2020

1 reference

Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR.

31 March 2020

1 reference

Initiating cellular stress responses

31 March 2020

1 reference

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

31 March 2020

1 reference

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

31 March 2020

1 reference

Cell division in the CNS: protective response or lethal event in post-mitotic neurons?

31 March 2020

1 reference

Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

31 March 2020

1 reference

Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis

31 March 2020

1 reference

Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis.

31 March 2020

1 reference

Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism.

31 March 2020

1 reference

Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia.

31 March 2020

1 reference

The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease

31 March 2020

1 reference

To die or grow: Parkinson's disease and cancer

31 March 2020

1 reference

Neuronal expression of cell cycle-related proteins after brain ischaemia in man.

31 March 2020

1 reference

Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis

31 March 2020

1 reference

Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.

31 March 2020

1 reference

Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death.

31 March 2020

1 reference

Selective cell death of hyperploid neurons in Alzheimer's disease

31 March 2020

1 reference

Pictures in molecular medicine: contemplating Alzheimer's disease as cancer: a loss of cell-cycle control.

31 March 2020

1 reference

Divide and die: cell cycle events as triggers of nerve cell death.

31 March 2020

1 reference

DNA hypomethylation leads to elevated mutation rates

31 March 2020

1 reference

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

31 March 2020

1 reference

Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene.

31 March 2020

1 reference

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

31 March 2020

1 reference

Dynamics of DNA methylation in aging and Alzheimer's disease

31 March 2020

1 reference

Tet family proteins and 5-hydroxymethylcytosine in development and disease

31 March 2020

1 reference

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.

31 March 2020

1 reference

Epigenetic mechanisms in neurological disease

31 March 2020

1 reference

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

31 March 2020

1 reference

TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1

31 March 2020

1 reference

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

31 March 2020

1 reference

Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage

31 March 2020

1 reference

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

31 March 2020

1 reference

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.

31 March 2020

1 reference

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

31 March 2020

1 reference

Changes in nuclear protein acetylation in u.v.-damaged human cells.

31 March 2020

1 reference

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

31 March 2020

1 reference

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia

31 March 2020

1 reference

Targeted proteomics for quantification of histone acetylation in Alzheimer's disease.

31 March 2020

1 reference

HDAC2 negatively regulates memory formation and synaptic plasticity.

31 March 2020

1 reference

An epigenetic blockade of cognitive functions in the neurodegenerating brain

31 March 2020

1 reference

Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing

31 March 2020

1 reference

Recovery of learning and memory is associated with chromatin remodelling

31 March 2020

1 reference

Potential of chromatin modifying compounds for the treatment of Alzheimer's disease

31 March 2020

1 reference

Sirtuin deacetylases in neurodegenerative diseases of aging

31 March 2020

1 reference

The logic linking protein acetylation and metabolism

31 March 2020

1 reference

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

31 March 2020

1 reference

Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain

31 March 2020

1 reference

Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

31 March 2020

1 reference

SIRT1 regulates the function of the Nijmegen breakage syndrome protein

31 March 2020

1 reference

Role of SIRT1 in homologous recombination

31 March 2020

1 reference

SIRT1 promotes DNA repair activity and deacetylation of Ku70

31 March 2020

1 reference

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

31 March 2020

1 reference

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

31 March 2020

1 reference

SIRT6 promotes DNA repair under stress by activating PARP1

31 March 2020

1 reference

SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling

31 March 2020

1 reference

Distinct patterns of sirtuin expression during progression of Alzheimer's disease.

31 March 2020

1 reference

CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease

31 March 2020

1 reference

Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

31 March 2020

1 reference

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

31 March 2020

1 reference

Alterations in mitochondrial membrane fluidity by lipid peroxidation products

31 March 2020

1 reference

Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

31 March 2020

1 reference

The sirtuins, oxidative stress and aging: an emerging link

31 March 2020

1 reference

Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3.

31 March 2020

1 reference

Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis

31 March 2020

1 reference

Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus

31 March 2020

1 reference

MicroRNA profiling: approaches and considerations

31 March 2020

1 reference

Mammalian microRNAs predominantly act to decrease target mRNA levels

31 March 2020

1 reference

Exceptional stories of microRNAs

31 March 2020

1 reference

MicroRNAs and neurodegeneration: role and impact

31 March 2020

1 reference

MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice

31 March 2020

1 reference

MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease

31 March 2020

1 reference

In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs.

31 March 2020

1 reference

The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.

31 March 2020

1 reference

miRNA response to DNA damage

31 March 2020

1 reference

ATM is down-regulated by N-Myc-regulated microRNA-421.

31 March 2020

1 reference

miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells

31 March 2020

1 reference

MicroRNA regulation of DNA repair gene expression in 4-aminobiphenyl-treated HepG2 cells

31 March 2020

1 reference

Context-dependent bidirectional regulation of the MutS homolog 2 by transforming growth factor β contributes to chemoresistance in breast cancer cells

31 March 2020

1 reference

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors

31 March 2020

1 reference

Characterization of ATM gene mutations in 66 ataxia telangiectasia families.

31 March 2020

1 reference

Ionizing radiation-induced oxidative stress alters miRNA expression

31 March 2020

1 reference

A microRNA component of the p53 tumour suppressor network

31 March 2020

1 reference

miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation

31 March 2020

1 reference

p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest

31 March 2020

1 reference

Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis

31 March 2020

1 reference

The ATM kinase induces microRNA biogenesis in the DNA damage response.

31 March 2020

1 reference

Sublethal doses of β-amyloid peptide abrogate DNA-dependent protein kinase activity

31 March 2020

1 reference

Binding to the minor groove of the double-strand, tau protein prevents DNA from damage by peroxidation

31 March 2020

1 reference

Tau protein binds single-stranded DNA sequence specifically--the proof obtained in vitro with non-equilibrium capillary electrophoresis of equilibrium mixtures.

31 March 2020

1 reference

Hyperphosphorylation results in tau dysfunction in DNA folding and protection

31 March 2020

1 reference

TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease

31 March 2020

1 reference

DNA methylation and healthy human aging

31 March 2020

1 reference

Oxidative stress induces DNA demethylation and histone acetylation in SH-SY5Y cells: potential epigenetic mechanisms in gene transcription in Aβ production

31 March 2020

1 reference

Cell cycle activation in postmitotic neurons is essential for DNA repair.

31 March 2020

1 reference

Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons

31 March 2020

1 reference

Effect of ionizing radiation in sensory ganglion neurons: organization and dynamics of nuclear compartments of DNA damage/repair and their relationship with transcription and cell cycle

31 March 2020

1 reference

Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus.

31 March 2020

1 reference

miR-9 regulation of BRCA1 and ovarian cancer sensitivity to cisplatin and PARP inhibition

31 March 2020

1 reference

miR-128 exerts pro-apoptotic effect in a p53 transcription-dependent and -independent manner via PUMA-Bak axis

31 March 2020

1 reference

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

31 March 2020

1 reference

MiR-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia-telangiectasia mutated

31 March 2020

1 reference

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

31 March 2020

1 reference

The DNA-damage response to γ-radiation is affected by miR-27a in A549 cells.

31 March 2020

1 reference

microRNA-34a promotes DNA damage and mitotic catastrophe.

31 March 2020

1 reference

miR-34a repression of SIRT1 regulates apoptosis

31 March 2020

1 reference

Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

31 March 2020

1 reference

MicroRNA-125b is a novel negative regulator of p53.

31 March 2020

1 reference

Tumor suppressor miR-145 reverses drug resistance by directly targeting DNA damage-related gene RAD18 in colorectal cancer.

31 March 2020

1 reference

miR-381, a novel intrinsic WEE1 inhibitor, sensitizes renal cancer cells to 5-FU by up-regulation of Cdc2 activities in 786-O.

31 March 2020

1 reference

The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer

31 March 2020

1 reference

MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons

31 March 2020

1 reference

miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary

31 March 2020

1 reference

Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3.

31 March 2020

1 reference

miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.

31 March 2020

1 reference

miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

31 March 2020

1 reference

Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers.

31 March 2020

1 reference

MicroRNA-124 (miR-124) regulates Ku70 expression and is correlated with neuronal death induced by ischemia/reperfusion

31 March 2020

1 reference

Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity

31 March 2020

1 reference

The induction of multiple cell cycle events precedes target-related neuronal death.

31 March 2020

1 reference

12 December 2020

Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders

1 reference

12 December 2020

Toward an early diagnosis and treatment of Alzheimer's disease

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12 December 2020

Enhanced DNA repair synthesis in hyperacetylated nucleosomes.

1 reference

12 December 2020

Tudor, MBT and chromo domains gauge the degree of lysine methylation

1 reference

12 December 2020

Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways

1 reference

12 December 2020

The Effects of SIRT1 on Alzheimer's Disease Models

1 reference

12 December 2020

Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?

1 reference

12 December 2020

DNA damage and base excision repair in mitochondria and their role in aging.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRN4020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26462757%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 June 2020

1003623063

0 references

Fatcat ID

release_zjxmlgezivep5chkqtmgs2juqy

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zjxmlgezivep5chkqtmgs2juqy

24 November 2022

mapped directly with Wikidata item

1 reference