Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies. (Q38601092)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26443675%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

title

Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies (English)

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26 February 2020

main subject

autism spectrum disorder

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1 reference

1

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26 February 2020

Laura Fusar-Poli

2

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26 February 2020

Stefano Damiani

4

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26 February 2020

Francesco Barale

5

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26 February 2020

Pierluigi Politi

6

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26 February 2020

author name string

Cristina Panisi

3

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26 February 2020

language of work or name

English

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publication date

1 March 2016

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Journal of Autism and Developmental Disorders

26 February 2020

published in

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26 February 2020

volume

46

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26 February 2020

issue

3

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26 February 2020

page(s)

825-839

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https://scigraph.springernature.com/pub.10.1007/s10803-015-2619-y

26 February 2020

exact match

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cites work

Advances in autism genetics: on the threshold of a new neurobiology

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Mechanism of nitrogen metabolism-related parameters and enzyme activities in the pathophysiology of autism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Association of social and cognitive impairment and biomarkers in autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

21 January 2018

Neuroanatomy of autism

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Neuroanatomic observations of the brain in autism: a review and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Risk and correlates of autism spectrum disorder in children with epilepsy: a community-based study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Flumazenil. A reappraisal of its pharmacological properties and therapeutic efficacy as a benzodiazepine antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Association between a GABRB3 polymorphism and autism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Minicolumnar abnormalities in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Pervasive developmental disorders in preschool children: confirmation of high prevalence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

GABA system dysfunction in autism and related disorders: from synapse to symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Relationship between chronic lead toxicity and plasma neurotransmitters in autistic patients from Saudi Arabia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

An open-label naturalistic pilot study of acamprosate in youth with autistic disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Brief report: acamprosate in fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

STX209 (arbaclofen) for autism spectrum disorders: an 8-week open-label study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Brief report: Pilot single-blind placebo lead-in study of acamprosate in youth with autistic disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Impact of acamprosate on behavior and brain-derived neurotrophic factor: an open-label study in youth with fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Expression of GABA(B) receptors is altered in brains of subjects with autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Downregulation of GABAA receptor protein subunits α6, β2, δ, ε, γ2, θ, and ρ2 in superior frontal cortex of subjects with autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

GABA(A) receptor downregulation in brains of subjects with autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Riluzole enhances glutamate uptake in rat astrocyte cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Riluzole as an adjunctive therapy to risperidone for the treatment of irritability in children with autistic disorder: a double-blind, placebo-controlled, randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

[3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Improving emotional face perception in autism with diuretic bumetanide: a proof-of-concept behavioral and functional brain imaging pilot study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 tesla instrument.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

A double-blind, placebo-controlled study of valproate for aggression in youth with pervasive developmental disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Divalproex sodium vs placebo for the treatment of irritability in children and adolescents with autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Divalproex sodium vs. placebo in the treatment of repetitive behaviours in autism spectrum disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Suppressed GABAergic inhibition as a common factor in suspected etiologies of autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

The clinical pharmacology of acamprosate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Absence of seizures despite high prevalence of epileptiform EEG abnormalities in children with autism monitored in a tertiary care center.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Association of GABRB3 polymorphisms with autism spectrum disorders in Korean trios.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Neurochemical and molecular pharmacological aspects of the GABA(B) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Arbaclofen placarbil, a novel R-baclofen prodrug: improved absorption, distribution, metabolism, and elimination properties compared with R-baclofen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Parvalbumin-, calbindin-, and calretinin-immunoreactive hippocampal interneuron density in autism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

The diuretic bumetanide decreases autistic behaviour in five infants treated during 3 months with no side effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

A randomised controlled trial of bumetanide in the treatment of autism in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: a pilot [(11)C]Ro15-4513 positron emission tomography study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Evaluation of the GABAergic nervous system in autistic brain: (123)I-iomazenil SPECT study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

New insights into the role of the GABA(A)-benzodiazepine receptor in psychiatric disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Decreased left perisylvian GABA concentration in children with autism and unaffected siblings

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Serotonin and amino acid content in platelets of autistic children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Correlation Between Hepatocyte Growth Factor (HGF) and Gamma-Aminobutyric Acid (GABA) Plasma Levels in Autistic Children

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Effects of anticonvulsant drugs on the cerebral enzymes metabolizing GABA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant mice: implications for autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Subunit composition, distribution and function of GABA(A) receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Carnosine modulates zinc and copper effects on amino acid receptors and synaptic transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Neurons in the fusiform gyrus are fewer and smaller in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Effect of flumazenil on GABAA receptors in isolated rat hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Three probands with autistic disorder and isodicentric chromosome 15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Pilot study of the behavioral effects of flumazenil in two children with autism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10803-015-2619-Y

The level of GAD67 protein is highly sensitive to small increases in intraneuronal gamma-aminobutyric acid levels.

21 January 2018

1 reference

12 December 2020

The pharmacology and function of central GABAB receptors.

1 reference

12 December 2020

Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010

1 reference

12 December 2020

Effect of Inhibitors of GABA Aminotransferase on the Metabolism of GABA in Brain Tissue and Synaptosomal Fractions

1 reference

12 December 2020

Elevated plasma gamma-aminobutyric acid (GABA) levels in autistic youngsters: stimulus for a GABA hypothesis of autism.

1 reference

12 December 2020

GABAergic signaling as therapeutic target for autism spectrum disorders

1 reference

12 December 2020

Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy

1 reference

12 December 2020

Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: a randomized, controlled, phase 2 trial

1 reference

12 December 2020

The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1

1 reference

12 December 2020

Developmental regulation of GABAergic signalling in the hippocampus of neuroligin 3 R451C knock-in mice: an animal model of Autism

1 reference

12 December 2020

Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC Autopsy Research Report.

1 reference

12 December 2020

10.1007/S10803-015-2619-Y

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26443675%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

26 February 2020

1021630839

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Fatcat ID

release_k5754b3nyze35cegccr76ygpd4

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24 November 2022

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