Flumazenil. A reappraisal of its pharmacological properties and therapeutic efficacy as a benzodiazepine antagonist (Q36716605)

15 August 2017

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title

Flumazenil. A reappraisal of its pharmacological properties and therapeutic efficacy as a benzodiazepine antagonist (English)

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15 August 2017

1

Brogden RN

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15 August 2017

Goa KL

2

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PubMed ID

1724638

15 August 2017

language of work or name

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1 December 1991

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15 August 2017

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15 August 2017

42

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15 August 2017

1061-1089

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15 August 2017

6

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https://scigraph.springernature.com/pub.10.2165/00003495-199142060-00010

15 August 2017

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cites work

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Flumazenil used for reversal of midazolam-induced sedation in endoscopy outpatients.

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Benzodiazepine antagonist Ro 15-1788. Antagonism of diazepam sedation in outpatients undergoing gastroscopy

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The anticonvulsant effect of the benzodiazepine antagonist, Ro 15-1788: an EEG study in 4 cases

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Additional subcutaneous administration of flumazenil does not shorten recovery time after midazolam.

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Pharmacokinetics of the new benzodiazepine antagonist Ro 15-1788 in man following intravenous and oral administration

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RO 15-1788 antagonises the central effects of diazepam in man without altering diazepam bioavailability

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Treatment of hepatic encephalopathy (HE) with the benzodiazepine antagonist flumazenil: a pilot study.

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Chronic treatment with lorazepam and FG 7142 may change the effects of benzodiazepine receptor agonists, antagonists and inverse agonists by different mechanisms

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Does the benzodiazepine antagonist Ro 15-1788 antagonize the action of ethanol?

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12 December 2020

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Benzodiazepine antagonism does not provoke a stress response.

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The anxiogenic action of Ro 15-1788 is reversed by chronic, but not by acute, treatment with chlordiazepoxide.

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12 December 2020

The reversal of midazolam sedation with the benzodiazepine antagonist flumazenil (Anexate).

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Effects of the benzodiazepine antagonist flumazenil on postoperative performance following total intravenous anaesthesia with midazolam and alfentanil.

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Induction agents for day-case anaesthesia. A double-blind comparison of propofol and midazolam antagonised by flumazenil.

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The effects of a benzodiazepine antagonist Ro 15-1788 in the presence of stable concentrations of midazolam.

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Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788.

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Combination of midazolam and flumazenil in upper gastrointestinal endoscopy, a doubleblind randomized study.

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Reversal of hepatic coma with flumazenil with improvement in visual evoked potentials

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12 December 2020

Flumazenil used in the antagonizing of diazepam and midazolam sedation in out-patients undergoing gastroscopy.

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Effects of the benzodiazepine receptor antagonist flumazenil in hepatic encephalopathy in humans.

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Pharmacokinetic-pharmacodynamic modelling of the interaction between flumazenil and midazolam in volunteers by aperiodic EEG analysis.

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Flumazenil: a possible treatment for benzodiazepine withdrawal anxiety.

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Absence of central effects in man of the benzodiazepine antagonist Ro 15-1788.

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The effect of Ro15-1788 (Anexate) on conscious sedation produced with midazolam.

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Randomized clinical investigation of Ro 15-1788, a benzodiazepine antagonist, in reversing the central effects of flunitrazepam.

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The respiratory effects of reversing midazolam sedation with flumazenil in the presence or absence of narcotics.

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Flumazenil in total intravenous anaesthesia using midazolam and fentanyl.

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12 December 2020

A three-state model of the benzodiazepine receptor explains the interactions between the benzodiazepine antagonist Ro 15-1788, benzodiazepine tranquilizers, ?-carbolines, and phenobarbitone

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12 December 2020

Methohexital vs midazolam/flumazenil anaesthesia during laryngoscopy under jet ventilation

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12 December 2020

Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man

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12 December 2020

[Ro 15-1788 antagonizes reliably the Benzodiazepine effect after Flunitrazepam combination anesthesias].

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12 December 2020

Clinical evaluation of a specific benzodiazepine antagonist (RO 15-1788). Studies in elderly patients after regional anaesthesia under benzodiazepine sedation

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12 December 2020

Persistent reversal of tolerance to anticonvulsant effects and GABAergic subsensitivity by a single exposure to benzodiazepine antagonist during chronic benzodiazepine administration.

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12 December 2020

Recovery from fixed-dose midazolam-induced anaesthesia and antagonism with flumazenil for outpatient arthroscopy

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12 December 2020

Reversal of flunitrazepam sedation with flumazenil. A randomized clinical trial.

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12 December 2020

Benzodiazepine intoxication treated with flumazenil (Anexate, RO 15-1788).

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12 December 2020

Pharmacokinetics and EEG effects of flumazenil in volunteers.

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12 December 2020

Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.

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12 December 2020

Use of flumazenil in intoxicated patients with coma. A double-blind placebo-controlled study in ICU

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12 December 2020

Successful long-term treatment of portal-systemic encephalopathy by the benzodiazepine antagonist flumazenil

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12 December 2020

Double-blind study of the reversal of midazolam-supplemented general anaesthesia with Ro 15-1788.

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12 December 2020

The value of flumazenil in the reversal of midazolam-induced sedation for upper gastrointestinal endoscopy.

1 reference

12 December 2020

Protection against the lethal effects of pentobarbital in mice by a benzodiazepine receptor inverse agonist, 6,7-dimethoxy-4-ethyl-3-carbomethoxy-beta-carboline

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12 December 2020

Pharmacology of Dormicum (midazolam) and Anexate (flumazenil).

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12 December 2020

Effects of flunitrazepam on memory and their reversal by two antagonists.

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12 December 2020

Interaction of Convulsive Ligands with Benzodiazepine Receptors

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12 December 2020

Cardiovascular responses to flumazenil-induced arousal after arterial surgery

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12 December 2020

Flumazenil Antagonism of Midazolam-induced Ventilatory Depression

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12 December 2020

The role of midazolam and flumazenil in urology.

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12 December 2020

Benzodiazepine antagonist (RO 15-1788) in ethanol intoxication: a pilot study

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12 December 2020

Improvement of hepatic encephalopathy treated with flumazenil

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12 December 2020

Reversal of benzodiazepine-induced sedation by intravenous Ro 15-1788.

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12 December 2020

Midazolam and flumazenil in gastroenterology.

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12 December 2020

Pharmacodynamic interaction between midazolam and a specific benzodiazepine antagonist in humans.

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12 December 2020

Death after flumazenil

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12 December 2020

Flumazenil provocation of panic attacks. Evidence for altered benzodiazepine receptor sensitivity in panic disorder

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12 December 2020

Speed of reversal of midazolam-induced respiratory depression by flumazenil--a study in patients undergoing upper G.I. endoscopy.

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12 December 2020

Reversal of slow-wave sleep by benzodiazepine antagonist Ro 15-1788.

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12 December 2020

Comparison of midazolam and diazepam in doses of comparable potency during gastroscopy

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12 December 2020

Flumazenil reverses sedation after midazolam-induced general anesthesia in ambulatory surgery patients.

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12 December 2020

Changes in noradrenaline plasma levels and behavioural responses induced by benzodiazepine agonists with the benzodiazepine antagonist Ro 15-1788.

1 reference

12 December 2020

The effect of the benzodiazepine antagonist, flumazenil, on psychometric performance in acute ethanol intoxication in man.

1 reference

12 December 2020

Benzodiazepine antagonist Ro 15-1788: Neurological and behavioral effects

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12 December 2020

Safety of rapid administration of flumazenil in patients with ischaemic heart disease.

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12 December 2020

Flumazenil causing convulsions and ventricular tachycardia

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12 December 2020

Flumazenil used for antagonizing the central effects of midazolam and diazepam in outpatients

1 reference

12 December 2020

The efficacy of flumazenil versus physostigmine after midazolam-alfentanil anaesthesia in man.

1 reference

12 December 2020

Effect of flumazenil on midazolam-induced amnesia

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12 December 2020

Reversal of midazolam sedation with anexate

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12 December 2020

Flumazenil in self-induced benzodiazepine poisoning

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12 December 2020

Antagonism of flunitrazepam-induced sedative effects by flumazenil in patients after surgery under general anaesthesia. A double-blind placebo-controlled investigation of efficacy and safety.

1 reference

12 December 2020

Flumazenil and hepatic encephalopathy

1 reference

12 December 2020

Death after flumazepil

1 reference

12 December 2020

Apparent pA2 estimation of benzodiazepine receptor antagonists.

1 reference

12 December 2020

The clinical anti-convulsant effects of flumazenil, a benzodiazepine antagonist

1 reference

12 December 2020

Ro 15-1788 antagonizes the effects of diazepam in man without affecting its bioavailability.

1 reference

12 December 2020

Flumazenil in the outpatient. A study following midazolam as sedation for upper gastrointestinal endoscopy.

1 reference

12 December 2020

[Antagonism of flunitrazepam and fentanyl by flumazenil, naloxone or nalbuphine]

1 reference

12 December 2020

Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study

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12 December 2020

Ventricular arrhythmia precipitated by flumazenil

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12 December 2020

Flumazenil. A preliminary review of its benzodiazepine antagonist properties, intrinsic activity and therapeutic use.

1 reference

12 December 2020

The effects of the benzodiazepine antagonist Ro 15-1788 on psychophysiological performance and subjective measures in normal subjects.

1 reference

12 December 2020

[Treatment of hepatic encephalopathy with flumazenil]

1 reference

12 December 2020

Antagonism of diazepam sedation by flumazenil.

1 reference

12 December 2020

Action of the benzodiazepine antagonist Ro 15-1788 in humans after sleep withdrawal.

1 reference

12 December 2020

Chronic treatment with Ro 15-1788 distinguishes between its benzodiazepine antagonist, agonist and inverse agonist properties.

1 reference

12 December 2020

Ro 15-1788 for postoperative recovery. A randomised clinical trial in patients undergoing minor surgical procedures under midazolam anaesthesia

1 reference

12 December 2020

Effects of a benzodiazepine antagonist on the diazepam-induced electrical brain activity modifications.

1 reference

12 December 2020

Effects of diazepam and flumazenil on sedation and hypoxic ventilatory response.

1 reference

12 December 2020

[Clinical investigation of flumazenil in reversing the respiratory effects of diazepam]

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12 December 2020

Reversal of flunitrazepam with flumazenil: duration of antagonist activity.

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12 December 2020

Intrinsic effects of the benzodiazepine receptor antagonist RO 15-1788 in sleepy and alert subjects

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12 December 2020

Effects of lorazepam on memory, attention and sedation in man: antagonism by Ro 15-1788.

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12 December 2020

Ro 15-1788 and hepatic failure

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12 December 2020

Antagonism of benzodiazepine-fentanyl anaesthesia with flumazenil

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12 December 2020

Effects of a specific benzodiazepine antagonist (RO 15-1788) on cerebral blood flow.

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12 December 2020

Benzodiazepine-receptor antagonist, a clinical double blind study

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12 December 2020

Time course of antagonism of sedative and amnesic effects of diazepam by flumazenil.

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12 December 2020

Preclinical pharmacology of midazolam

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12 December 2020

The use of flumazenil as an antagonist to midazolam in intravenous sedation for dental procedures.

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12 December 2020

Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands

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12 December 2020

Day-case surgery: enhanced recovery with flumazenil.

1 reference

12 December 2020

Antagonism of diazepam-induced sedative effects by Ro15-1788 in patients after surgery under lumbar epidural block. A double-blind placebo-controlled investigation of efficacy and safety

1 reference

12 December 2020

Coronary and left ventricular hemodynamic responses following reversal of flunitrazepam-induced sedation with flumazenil in patients with coronary artery disease.

1 reference

12 December 2020

Imaging of [11C]-labelled Ro 15-1788 binding to benzodiazepine receptors in the human brain by positron emission tomography

1 reference

12 December 2020

Benzodiazepine poisoning: experience of 702 admissions to an intensive care unit during a 14-year period

1 reference

12 December 2020

The effect of flumazenil (Ro 15-1788) in the management of self-induced benzodiazepine poisoning. A double-blind controlled study

1 reference

12 December 2020

10.2165/00003495-199142060-00010

Identifiers

DOI

1 reference

PubMed ID

1724638

Dimensions Publication ID

15 August 2017

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1 reference

PubMed ID

1724638