Promising Targets for the Treatment of Neurodegenerative Diseases (Q38562084)

4 September 2017

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title

Promising Targets for the Treatment of Neurodegenerative Diseases (English)

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4 September 2017

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S L Budd Haeberlein

1

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PubMed ID

26250447

4 September 2017

T J R Harris

series ordinal

2

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PubMed ID

26250447

4 September 2017

language of work or name

English

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publication date

6 August 2015

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Clinical Pharmacology & Therapeutics

4 September 2017

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4 September 2017

98

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4 September 2017

5

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4 September 2017

492-501

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

4 September 2017

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Amyloid-ß-directed immunotherapy for Alzheimer's disease

21 January 2018

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γ-Secretase inhibitors and modulators

21 January 2018

1 reference

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

21 January 2018

1 reference

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

1 reference

Tau protein kinases: involvement in Alzheimer's disease

21 January 2018

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Propagation of tau misfolding from the outside to the inside of a cell.

21 January 2018

1 reference

Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

21 January 2018

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Constitutive secretion of tau protein by an unconventional mechanism.

21 January 2018

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Anti-tau antibody reduces insoluble tau and decreases brain atrophy

21 January 2018

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Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models

21 January 2018

1 reference

Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

21 January 2018

1 reference

Impact of apolipoprotein E on Alzheimer's disease

21 January 2018

1 reference

TREM2 Variants in Alzheimer's Disease

21 January 2018

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The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk.

21 January 2018

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Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

21 January 2018

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

21 January 2018

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

21 January 2018

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The remarkable conformational plasticity of alpha-synuclein: blessing or curse?

21 January 2018

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Pathological roles of α-synuclein in neurological disorders

21 January 2018

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Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

21 January 2018

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Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

21 January 2018

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α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

21 January 2018

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Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration

21 January 2018

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Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.

21 January 2018

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Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred

21 January 2018

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The neuropathology of genetic Parkinson's disease

21 January 2018

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LRRK2 in Parkinson's disease: genetic and clinical studies from patients

21 January 2018

1 reference

The role of the LRRK2 gene in Parkinsonism

21 January 2018

1 reference

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study

21 January 2018

1 reference

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

21 January 2018

1 reference

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

21 January 2018

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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

21 January 2018

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Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

21 January 2018

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Glucocerebrosidase mutations and the pathogenesis of Parkinson disease

21 January 2018

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

21 January 2018

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Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases

21 January 2018

1 reference

State of play in amyotrophic lateral sclerosis genetics

21 January 2018

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Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

21 January 2018

1 reference

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

21 January 2018

1 reference

The widening spectrum of C9ORF72-related disease; genotype/phenotype correlations and potential modifiers of clinical phenotype

21 January 2018

1 reference

Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study

21 January 2018

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Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

21 January 2018

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A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

21 January 2018

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The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

21 January 2018

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Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.

21 January 2018

1 reference

Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic

21 January 2018

1 reference

Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS.

21 January 2018

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Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion

21 January 2018

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Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

21 January 2018

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Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

21 January 2018

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Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders.

21 January 2018

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FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells

21 January 2018

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FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions

21 January 2018

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TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis

21 January 2018

1 reference

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

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TARDBP mutations in frontotemporal lobar degeneration: frequency, clinical features, and disease course.

21 January 2018

1 reference

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

21 January 2018

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The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.

21 January 2018

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Delineation of the core aggregation sequences of TDP-43 C-terminal fragment.

21 January 2018

1 reference

Widespread expression of Huntington's disease gene (IT15) protein product

21 January 2018

1 reference

Expanded ATXN2 CAG repeat size in ALS identifies genetic overlap between ALS and SCA2.

21 January 2018

1 reference

Mutant protein in Huntington disease is resistant to proteolysis in affected brain

21 January 2018

1 reference

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

21 January 2018

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Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum

21 January 2018

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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

21 January 2018

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Cortical and subcortical argyrophilic grains characterize a disease associated with adult onset dementia

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/CPT.195

1 reference

4 September 2017

1 reference

PubMed ID

26250447