Computer-aided design of T-cell epitope-based vaccines: addressing population coverage (Q38554524)

4 September 2017

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title

Computer-aided design of T-cell epitope-based vaccines: addressing population coverage (English)

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4 September 2017

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computer-aided design

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B Kobe

2

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author name string

P Oyarzun

series ordinal

1

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4 September 2017

24 July 2015

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International Journal of Immunogenetics

4 September 2017

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4 September 2017

42

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4 September 2017

313-321

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4 September 2017

5

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PolyCTLDesigner: a computational tool for constructing polyepitope T-cell antigens

4 September 2017

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Towards universal structure-based prediction of class II MHC epitopes for diverse allotypes

21 January 2018

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MultiRTA: a simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes

21 January 2018

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Characterization of HIV-specific CD4+ T cell responses against peptides selected with broad population and pathogen coverage

21 January 2018

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Antigen three-dimensional structure guides the processing and presentation of helper T-cell epitopes.

21 January 2018

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Evaluation of T-cell responses to peptides with MHC class I-binding motifs derived from PE_PGRS 33 protein of Mycobacterium tuberculosis

21 January 2018

1 reference

Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens.

21 January 2018

1 reference

HIV vaccine development by computer assisted design: the GAIA vaccine

21 January 2018

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Quantitative modeling of peptide binding to TAP using support vector machine

21 January 2018

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Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.

21 January 2018

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T-cell epitope prediction and immune complex simulation using molecular dynamics: state of the art and persisting challenges

21 January 2018

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Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactions.

21 January 2018

1 reference

Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations

21 January 2018

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Impact of MHC class I diversity on immune control of immunodeficiency virus replication

21 January 2018

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T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model

21 January 2018

1 reference

NetMHCIIpan-3.0, a common pan-specific MHC class II prediction method including all three human MHC class II isotypes, HLA-DR, HLA-DP and HLA-DQ.

21 January 2018

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pDOCK: a new technique for rapid and accurate docking of peptide ligands to Major Histocompatibility Complexes

21 January 2018

1 reference

An integrative approach to CTL epitope prediction: a combined algorithm integrating MHC class I binding, TAP transport efficiency, and proteasomal cleavage predictions.

21 January 2018

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Estimating design space available for polyepitopes through consideration of major histocompatibility complex binding motifs.

21 January 2018

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Peptide Vaccine: Progress and Challenges

21 January 2018

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A rational strategy to design multiepitope immunogens based on multiple Th lymphocyte epitopes.

21 January 2018

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NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11

21 January 2018

1 reference

Significance of the six peptide-binding pockets of HLA-A2.1 in influenza A matrix peptide-specific cytotoxic T-lymphocyte reactivity

21 January 2018

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MHC-based vaccination approaches: progress and perspectives

21 January 2018

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Selection of conserved epitopes from hepatitis C virus for pan-populational stimulation of T-cell responses.

21 January 2018

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Protection against chronic infection and AIDS by an HIV envelope peptide-cocktail vaccine in a pathogenic SHIV-rhesus model

21 January 2018

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The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage

21 January 2018

1 reference

NetMHCpan, a method for quantitative predictions of peptide binding to any HLA-A and -B locus protein of known sequence

21 January 2018

1 reference

PREDIVAC: CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity

21 January 2018

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A bioinformatics tool for epitope-based vaccine design that accounts for human ethnic diversity: application to emerging infectious diseases

21 January 2018

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Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors.

21 January 2018

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More than one reason to rethink the use of peptides in vaccine design

21 January 2018

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PEPVAC: a web server for multi-epitope vaccine development based on the prediction of supertypic MHC ligands

21 January 2018

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Prediction of MHC class I binding peptides using profile motifs.

21 January 2018

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A vaccine encoding conserved promiscuous HIV CD4 epitopes induces broad T cell responses in mice transgenic to multiple common HLA class II molecules

21 January 2018

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The IPD and IMGT/HLA database: allele variant databases

21 January 2018

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Predicting binding affinities of protein ligands from three-dimensional models: application to peptide binding to class I major histocompatibility proteins.

21 January 2018

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CD4+ T cell epitope discovery and rational vaccine design

21 January 2018

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Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design

21 January 2018

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Predicting proteasomal cleavage sites: a comparison of available methods

21 January 2018

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Evaluation of peptide selection approaches for epitope-based vaccine design

21 January 2018

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Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism

21 January 2018

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Optimizing vaccine design for cellular processing, MHC binding and TCR recognition

21 January 2018

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Designing peptide-based HIV vaccine for Chinese.

21 January 2018

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ProPred: prediction of HLA-DR binding sites.

21 January 2018

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Innovative bioinformatic approaches for developing peptide-based vaccines against hypervariable viruses

21 January 2018

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NetCTLpan: pan-specific MHC class I pathway epitope predictions

21 January 2018

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Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products

21 January 2018

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OptiTope--a web server for the selection of an optimal set of peptides for epitope-based vaccines.

21 January 2018

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Towards in silico design of epitope-based vaccines

21 January 2018

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A mathematical framework for the selection of an optimal set of peptides for epitope-based vaccines

21 January 2018

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Universal peptide vaccines - optimal peptide vaccine design based on viral sequence conservation

21 January 2018

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Virus-epitope vaccine design: informatic matching the HLA-I polymorphism to the virus genome.

21 January 2018

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The immune epitope database (IEDB) 3.0.

21 January 2018

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Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design

21 January 2018

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Limitations of Ab initio predictions of peptide binding to MHC class II molecules

21 January 2018

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MULTIPRED2: a computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles

21 January 2018

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TEPITOPEpan: extending TEPITOPE for peptide binding prediction covering over 700 HLA-DR molecules

21 January 2018

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Toward more accurate pan-specific MHC-peptide binding prediction: a review of current methods and tools.

21 January 2018

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A novel MHCp binding prediction model.

21 January 2018

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Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IJI.12214

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4 September 2017

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PubMed ID

26211755