The correlation and prognostic significance of MGMT promoter methylation and MGMT protein in glioblastomas (Q38491783)

3 September 2017

The correlation and prognostic significance of MGMT promoter methylation and MGMT protein in glioblastomas (English)

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3 September 2017

Van Thang Cao

1

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3 September 2017

Tae-Young Jung

2

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3 September 2017

Shin Jung

3

1 reference

3 September 2017

Shu-Guang Jin

4

1 reference

3 September 2017

Kyung-Sub Moon

5

1 reference

3 September 2017

In-Young Kim

6

1 reference

3 September 2017

Sam-Suk Kang

7

1 reference

3 September 2017

Chang-Soo Park

8

1 reference

3 September 2017

Kyung-Hwa Lee

9

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3 September 2017

Hong-Jae Chae

10

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3 September 2017

language of work or name

English

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publication date

1 November 2009

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3 September 2017

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3 September 2017

65

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3 September 2017

866-75; discussion 875

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3 September 2017

5

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Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea.

3 September 2017

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Effect of the extent of surgical resection on survival and quality of life in patients with supratentorial glioblastomas and anaplastic astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Inactivation of O6-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Regulation of the human O(6)-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Correlation of clinical features and methylation status of MGMT gene promoter in glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

O6-methylguanine-DNA methyltransferase regulation by p53 in astrocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

MGMT prognostic impact on glioblastoma is dependent on therapeutic modalities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

MGMT: its role in cancer aetiology and cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O6-methylguanine DNA methyltransferase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Novel mechanism whereby nuclear factor kappaB mediates DNA damage repair through regulation of O(6)-methylguanine-DNA-methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Variability and regulation of O6-alkylguanine-DNA alkyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Immunohistochemical study for O6-methylguanine-DNA methyltransferase in the non-neoplastic and neoplastic components of gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Intercellular heterogeneity of expression of the MGMT DNA repair gene in pediatric medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Careful exclusion of non-neoplastic brain components is required for an appropriate evaluation of O6-methylguanine-DNA methyltransferase status in glioma: relationship between immunohistochemistry and methylation analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1227%2F01.NEU.0000357325.90347.A1

10.1227/01.NEU.0000357325.90347.A1

21 January 2018

Identifiers

DOI

1 reference

3 September 2017

1 reference