Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family (Q38434032)

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11 March 2020

title

Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family (English)

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11 March 2020

11

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Fraser Hof

13

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11 March 2020

author name string

Natalia Milosevich

1

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Michael C Gignac

2

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James McFarlane

3

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Chakravarthi Simhadri

4

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Shanti Horvath

5

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Kevin D Daze

6

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Caitlin S Croft

7

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Aman Dheri

8

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Taylor T H Quon

9

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Sarah F Douglas

10

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Irina Paci

12

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publication date

7 December 2015

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ACS Medicinal Chemistry Letters

11 March 2020

published in

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volume

7

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issue

2

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page(s)

139-144

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Small-molecule modulators of methyl-lysine binding for the CBX7 chromodomain

11 March 2020

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6 September 2017

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The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface

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Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.

6 September 2017

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Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains

6 September 2017

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Identification of methyllysine peptides binding to chromobox protein homolog 6 chromodomain in the human proteome

6 September 2017

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Targeting MYCN in neuroblastoma by BET bromodomain inhibition

6 September 2017

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Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

6 September 2017

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RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells

6 September 2017

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Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

6 September 2017

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Identification and characterization of small molecule inhibitors of a plant homeodomain finger

6 September 2017

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BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

6 September 2017

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MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation

6 September 2017

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Druggability of methyl-lysine binding sites

6 September 2017

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6 September 2017

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6 September 2017

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Biophysical probes reveal a "compromise" nature of the methyl-lysine binding pocket in L3MBTL1.

6 September 2017

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6 September 2017

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Recognition and Specificity Determinants of the Human Cbx Chromodomains

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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27 September 2017

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10.1021/ACSMEDCHEMLETT.5B00378

31 August 2018

Identifiers

DOI

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11 March 2020

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