Protein engineering and the use of molecular modeling and simulation: the case of heterodimeric Fc engineering (Q38419449)

2 September 2017

Protein engineering and the use of molecular modeling and simulation: the case of heterodimeric Fc engineering (English)

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2 September 2017

Thomas Spreter Von Kreudenstein

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1

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2 September 2017

Paula I Lario

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2

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2 September 2017

Surjit B Dixit

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3

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2 September 2017

language of work or name

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6 November 2013

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2 September 2017

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2 September 2017

65

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2 September 2017

77-94

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2 September 2017

1

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Dual targeting strategies with bispecific antibodies

2 September 2017

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Hybrid hybridomas and their use in immunohistochemistry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

An efficient route to human bispecific IgG.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Production of stable bispecific IgG1 by controlled Fab-arm exchange: scalability from bench to large-scale manufacturing by application of standard approaches.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Bispecific human IgG by design

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Therapeutic assessment of SEED: a new engineered antibody platform designed to generate mono- and bispecific antibodies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Folding and association of the antibody domain CH3: prolyl isomerization preceeds dimerization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Folding and oxidation of the antibody domain C(H)3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Contributions of a disulfide bond to the structure, stability, and dimerization of human IgG1 antibody CH3 domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Improving biophysical properties of a bispecific antibody scaffold to aid developability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Specificity versus stability in computational protein design

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Automated design of specificity in molecular recognition

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

A de novo designed protein protein interface

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Configurations of Polypeptide Chains With Favored Orientations Around Single Bonds: Two New Pleated Sheets

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Is alpha-keratin a coiled coil?

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Stereochemistry of polypeptide chain configurations

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

The Catalytic and Regulatory Properties of Enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Protein dynamics and allostery: an NMR view

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Biomolecular simulation: a computational microscope for molecular biology

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

To milliseconds and beyond: challenges in the simulation of protein folding

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

How fast-folding proteins fold

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Fast and accurate side-chain topology and energy refinement (FASTER) as a new method for protein structure optimization.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Exact rotamer optimization for protein design

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

A smoothed backbone-dependent rotamer library for proteins derived from adaptive kernel density estimates and regressions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

The backrub motion: how protein backbone shrugs when a sidechain dances

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Backbone flexibility in computational protein design

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

A kinematic view of loop closure.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Cyclic coordinate descent: A robotics algorithm for protein loop closure.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

High-resolution prediction of protein helix positions and orientations.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Progress in computational protein design

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Computer-aided design of functional protein interactions

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Building macromolecular assemblies by information-driven docking: introducing the HADDOCK multibody docking server

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Local water bridges and protein conformational stability

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

A "solvated rotamer" approach to modeling water-mediated hydrogen bonds at protein-protein interfaces

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

The stability effects of protein mutations appear to be universally distributed

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

The Amber biomolecular simulation programs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Comparison of multiple Amber force fields and development of improved protein backbone parameters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Recent Developments and Applications of the CHARMM force fields

7 January 2021

1 reference

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A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

7 January 2021

1 reference

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Potential energy functions for atomic-level simulations of water and organic and biomolecular systems

7 January 2021

1 reference

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Poisson–Boltzmann Methods for Biomolecular Electrostatics

7 January 2021

1 reference

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Exploring protein native states and large-scale conformational changes with a modified generalized born model

7 January 2021

1 reference

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Energy functions for protein design I: efficient and accurate continuum electrostatics and solvation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

On the nonpolar hydration free energy of proteins: surface area and continuum solvent models for the solute-solvent interaction energy.

7 January 2021

1 reference

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Implicit modeling of nonpolar solvation for simulating protein folding and conformational transitions.

7 January 2021

1 reference

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Statistical mechanics and molecular dynamics in evaluating thermodynamic properties of biomolecular recognition

7 January 2021

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Calculation of protein-ligand binding affinities.

7 January 2021

1 reference

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Converging free energy estimates: MM-PB(GB)SA studies on the protein-protein complex Ras-Raf.

7 January 2021

1 reference

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Free-energy analysis of enzyme-inhibitor binding: aspartic proteinase-pepstatin complexes

7 January 2021

1 reference

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Scientific benchmarks for guiding macromolecular energy function improvement

7 January 2021

1 reference

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Estimation of conformational entropy in protein-ligand interactions: a computational perspective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Entropy calculations on the molten globule state of a protein: Side-chain entropies of α-lactalbumin

7 January 2021

1 reference

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Vibrational subsystem analysis: A method for probing free energies and correlations in the harmonic limit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Empirical potentials and functions for protein folding and binding.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

A novel side-chain orientation dependent potential derived from random-walk reference state for protein fold selection and structure prediction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Very fast empirical prediction and rationalization of protein pKa values

7 January 2021

1 reference

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Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Comparison of simple potential functions for simulating liquid water

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Molecular dynamics with coupling to an external bath

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

OpenMM 4: A Reusable, Extensible, Hardware Independent Library for High Performance Molecular Simulation

7 January 2021

1 reference

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Extending the accuracy limits of prediction for side-chain conformations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Parametrized Models of Aqueous Free Energies of Solvation Based on Pairwise Descreening of Solute Atomic Charges from a Dielectric Medium

7 January 2021

1 reference

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The weighted-volume derivative of a space-filling diagram

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

LC-MS characterization and purity assessment of a prototype bispecific antibody

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Contribution of domain interface residues to the stability of antibody CH3 domain homodimers.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

Designing specific protein-protein interactions using computation, experimental library screening, or integrated methods

7 January 2021

1 reference

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Leveraging SBDD in protein therapeutic development: antibody engineering.

7 January 2021

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Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

7 January 2021

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Community-wide assessment of protein-interface modeling suggests improvements to design methodology

7 January 2021

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A medicinal chemist's guide to molecular interactions

7 January 2021

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The errors of our ways: taking account of error in computer-aided drug design to build confidence intervals for our next 25 years

7 January 2021

1 reference

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Backbone-dependent rotamer library for proteins. Application to side-chain prediction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2013.10.016

10.1016/J.YMETH.2013.10.016

7 January 2021

Identifiers

DOI

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release_vy7anwvnpffbbdawu6667pvsby

2 September 2017

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Fatcat

https://api.fatcat.wiki/v0/release/vy7anwvnpffbbdawu6667pvsby

mapped directly with Wikidata item

24 November 2022

based on heuristic

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