TDP-43 in amyotrophic lateral sclerosis - is it a prion disease? (Q38407804)

2 September 2017

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title

TDP-43 in amyotrophic lateral sclerosis - is it a prion disease? (English)

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amyotrophic lateral sclerosis

2 September 2017

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author name string

A C Ludolph

series ordinal

1

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PubMed ID

25846565

2 September 2017

J Brettschneider

series ordinal

2

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2 September 2017

1 May 2015

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European Journal of Neurology

2 September 2017

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2 September 2017

22

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2 September 2017

5

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2 September 2017

753-761

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Amyotrophic lateral sclerosis

2 September 2017

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Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?

21 January 2018

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ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration

21 January 2018

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Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

21 January 2018

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

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Prion-like transmission of protein aggregates in neurodegenerative diseases

21 January 2018

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Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

21 January 2018

1 reference

Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis

21 January 2018

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Epidemiology and genetics of frontotemporal dementia/Pick's disease.

21 January 2018

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Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology.

21 January 2018

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Incidence of dementia with Lewy bodies and Parkinson disease dementia

21 January 2018

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

21 January 2018

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Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

21 January 2018

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Novel proteinaceous infectious particles cause scrapie

21 January 2018

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Insights into prion strains and neurotoxicity

21 January 2018

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Neurodegeneration: Alzheimer's disease under strain.

21 January 2018

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Human prion diseases: from Kuru to variant Creutzfeldt-Jakob disease

21 January 2018

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The transcellular spread of cytosolic amyloids, prions, and prionoids

21 January 2018

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Distinct α-synuclein strains differentially promote tau inclusions in neurons

21 January 2018

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Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice

21 January 2018

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Distinct tau prion strains propagate in cells and mice and define different tauopathies

21 January 2018

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Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone

21 January 2018

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The fluorescent Congo red derivative, (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains

21 January 2018

1 reference

TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions

21 January 2018

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TDP-43 skeins show properties of amyloid in a subset of ALS cases

21 January 2018

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Induction of amyloid fibrils by the C-terminal fragments of TDP-43 in amyotrophic lateral sclerosis

21 January 2018

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Identifying the amylome, proteins capable of forming amyloid-like fibrils

21 January 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

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Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.

21 January 2018

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Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

21 January 2018

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The spectrum of disease in chronic traumatic encephalopathy

21 January 2018

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Can lesions to the motor cortex induce amyotrophic lateral sclerosis?

21 January 2018

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Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players

21 January 2018

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Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

21 January 2018

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

21 January 2018

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Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

21 January 2018

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Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles

21 January 2018

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Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy.

21 January 2018

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Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

21 January 2018

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Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats

21 January 2018

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Transmission and spreading of tauopathy in transgenic mouse brain

21 January 2018

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

21 January 2018

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Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

21 January 2018

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A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions

21 January 2018

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Prion-like properties of pathological TDP-43 aggregates from diseased brains

21 January 2018

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Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain.

21 January 2018

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In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

21 January 2018

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Trans-cellular propagation of Tau aggregation by fibrillar species

21 January 2018

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Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

21 January 2018

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Exosomal cell-to-cell transmission of alpha synuclein oligomers.

21 January 2018

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

21 January 2018

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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

21 January 2018

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Propagation of tau misfolding from the outside to the inside of a cell.

21 January 2018

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Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

21 January 2018

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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

21 January 2018

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Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

21 January 2018

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Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.

21 January 2018

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Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

21 January 2018

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Prions hijack tunnelling nanotubes for intercellular spread

21 January 2018

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The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.

21 January 2018

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Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

21 January 2018

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Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

21 January 2018

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Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

21 January 2018

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Neuropathological stageing of Alzheimer-related changes

21 January 2018

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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

21 January 2018

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Neuronal cytoskeletal changes are an early consequence of repetitive head injury

21 January 2018

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Stages of pTDP-43 pathology in amyotrophic lateral sclerosis

21 January 2018

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Diffusion tensor imaging analysis of sequential spreading of disease in amyotrophic lateral sclerosis confirms patterns of TDP-43 pathology

21 January 2018

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Cognitive impairment in amyotrophic lateral sclerosis

21 January 2018

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TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

21 January 2018

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Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.

21 January 2018

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TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease

21 January 2018

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TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype.

21 January 2018

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Temporal lobar predominance of TDP-43 neuronal cytoplasmic inclusions in Alzheimer disease

21 January 2018

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Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype.

21 January 2018

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Staging TDP-43 pathology in Alzheimer's disease

21 January 2018

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Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD).

21 January 2018

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A harmonized classification system for FTLD-TDP pathology

21 January 2018

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Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

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Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

21 January 2018

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Amyotrophic lateral sclerosis--a model of corticofugal axonal spread

21 January 2018

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TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord

21 January 2018

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The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug

21 January 2018

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Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

21 January 2018

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

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Cellular mechanisms of protein aggregate propagation

21 January 2018

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Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration

21 January 2018

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Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/ENE.12706

1 reference

2 September 2017

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PubMed ID

25846565