Prediction of drug-ABC-transporter interaction--Recent advances and future challenges. (Q38377104)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25769815%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

review article

2 references

6 July 2021

Prediction of drug-ABC-transporter interaction--Recent advances and future challenges (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25769815%20AND%20SRC:MED&resulttype=core&format=json

ATP-binding cassette transporter

2 March 2020

main subject

1 reference

6 July 2021

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25769815%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

author name string

Gerhard F Ecker

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25769815%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

language of work or name

English

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publication date

11 March 2015

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Advanced Drug Delivery Reviews

2 March 2020

23 June 2015

1 reference

6 July 2021

2 references

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2 March 2020

6 July 2021

86

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2 March 2020

page(s)

17-26

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Creative Commons Attribution 4.0 International

2 March 2020

copyright license

1 reference

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

6 July 2021

0 references

1 reference

12 December 2020

Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes

1 reference

12 December 2020

C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance

1 reference

12 December 2020

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

1 reference

12 December 2020

Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier

1 reference

12 December 2020

Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells

1 reference

12 December 2020

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

1 reference

12 December 2020

Mutational analysis of the MRP2 gene and long-term follow-up of Dubin-Johnson syndrome in Japan.

1 reference

12 December 2020

Computational approaches to modeling drug transporters.

1 reference

12 December 2020

The ABC protein turned chloride channel whose failure causes cystic fibrosis

1 reference

12 December 2020

Synergistic inhibition by verapamil and quinine of P-glycoprotein-mediated multidrug resistance in a human myeloma cell line model

1 reference

12 December 2020

Drug-target residence time and its implications for lead optimization

1 reference

12 December 2020

Structure of a bacterial multidrug ABC transporter

1 reference

12 December 2020

Pharmacophore-based discovery of ligands for drug transporters

1 reference

12 December 2020

How can we best use structural information on P-glycoprotein to design inhibitors?

1 reference

12 December 2020

Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP

1 reference

12 December 2020

Flexibility in the ABC transporter MsbA: Alternating access with a twist

1 reference

12 December 2020

Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics

1 reference

12 December 2020

Computational models for prediction of interactions with ABC-transporters

1 reference

12 December 2020

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

1 reference

12 December 2020

Substrate-dependent breast cancer resistance protein (Bcrp1/Abcg2)-mediated interactions: consideration of multiple binding sites in in vitro assay design

1 reference

12 December 2020

P-gp inhibition potential in cell-based models: which "calculation" method is the most accurate?

1 reference

12 December 2020

Support vector machine and pharmacophore-based prediction models of multidrug-resistance protein 2 (MRP2) inhibitors.

1 reference

12 December 2020

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

1 reference

12 December 2020

Human ATP-binding cassette (ABC) transporter family

1 reference

12 December 2020

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs.

1 reference

12 December 2020

Structure-activity relationships and quantitative structure-activity relationships for breast cancer resistance protein (ABCG2).

1 reference

12 December 2020

Reversal of multidrug resistance by verapamil and modulation by alpha 1-acid glycoprotein in wild-type and multidrug-resistant Chinese hamster ovary cell lines

1 reference

12 December 2020

New strategies to deliver anticancer drugs to brain tumors

1 reference

12 December 2020

Tangier disease caused by compound heterozygosity for ABCA1 mutations R282X and Y1532C.

1 reference

12 December 2020

Predicting ligand interactions with ABC transporters in ADME.

1 reference

12 December 2020

8-Prenylnaringenin is an inhibitor of multidrug resistance-associated transporters, P-glycoprotein and MRP1.

1 reference

12 December 2020

New uses for old drugs: pharmacophore-based screening for the discovery of P-glycoprotein inhibitors

1 reference

12 December 2020

A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields

1 reference

12 December 2020

ADME evaluation in drug discovery. 10. Predictions of P-glycoprotein inhibitors using recursive partitioning and naive Bayesian classification techniques.

1 reference

12 December 2020

Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein

1 reference

12 December 2020

P-glycoprotein substrate models using support vector machines based on a comprehensive data set.

1 reference

12 December 2020

Toward a Better Pharmacophore Description of P-Glycoprotein Modulators, Based on Macrocyclic Diterpenes from Euphorbia Species

1 reference

12 December 2020

Predicting binding to p-glycoprotein by flexible receptor docking

1 reference

12 December 2020

In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.

1 reference

12 December 2020

Computational models for predicting substrates or inhibitors of P-glycoprotein

1 reference

12 December 2020

ABCG2/BCRP dysfunction as a major cause of gout

1 reference

12 December 2020

PubChem's BioAssay Database

1 reference

12 December 2020

Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation

1 reference

12 December 2020

Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein

1 reference

12 December 2020

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification

1 reference

12 December 2020

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

1 reference

12 December 2020

Role of ABC transporters in the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

An In Silico Classification Model for Putative ABCC2 Substrates

1 reference

12 December 2020

Lipid bilayer properties control membrane partitioning, binding, and transport of p-glycoprotein substrates.

1 reference

12 December 2020

Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions

1 reference

12 December 2020

Annotating Human P-Glycoprotein Bioassay Data

1 reference

12 December 2020

Role of ABC transporters in lipid transport and human disease

1 reference

12 December 2020

Identification of novel breast cancer resistance protein (BCRP) inhibitors by virtual screening

1 reference

12 December 2020

Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2).

1 reference

12 December 2020

Predicting substrates of the human breast cancer resistance protein using a support vector machine method

1 reference

12 December 2020

Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position.

1 reference

12 December 2020

Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.

1 reference

12 December 2020

On the origin of large flexibility of P-glycoprotein in the inward-facing state

1 reference

12 December 2020

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

1 reference

12 December 2020

Molecular docking characterizes substrate-binding sites and efflux modulation mechanisms within P-glycoprotein.

1 reference

12 December 2020

P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387.

1 reference

12 December 2020

Can long range mechanical interaction between drugs and membrane proteins define the notion of molecular promiscuity? Application to P-glycoprotein-mediated multidrug resistance (MDR).

1 reference

12 December 2020

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

1 reference

12 December 2020

Ligand and structure-based classification models for prediction of P-glycoprotein inhibitors

1 reference

12 December 2020

ATP-binding cassette transporters in liver

1 reference

12 December 2020

Refined structures of mouse P-glycoprotein

1 reference

12 December 2020

The ChEMBL bioactivity database: an update

1 reference

12 December 2020

The role of canalicular ABC transporters in cholestasis

1 reference

12 December 2020

ADMET evaluation in drug discovery. 13. Development of in silico prediction models for P-glycoprotein substrates

1 reference

12 December 2020

P-glycoprotein modulates morphine uptake into the CNS: a role for the non-steroidal anti-inflammatory drug diclofenac

1 reference

12 December 2020

In silico identification and in vitro validation of potential cholestatic compounds through 3D ligand-based pharmacophore modeling of BSEP inhibitors.

1 reference

12 December 2020

Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4

1 reference

12 December 2020

Minimizing Drug Exposure in the CNS while Maintaining Good Oral Absorption

1 reference

12 December 2020

Clarification of P-glycoprotein inhibition-related drug-drug interaction risks based on a literature search of the clinical information.

1 reference

12 December 2020

Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) restrict oral availability and brain accumulation of the PARP inhibitor rucaparib (AG-014699).

1 reference

12 December 2020

A multivariate approach linking reported side effects of clinical antidepressant and antipsychotic trials to in vitro binding affinities

1 reference

12 December 2020

Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter

1 reference

12 December 2020

Insights on P-Glycoprotein's Efflux Mechanism Obtained by Molecular Dynamics Simulations.

1 reference

12 December 2020

BCRP Inhibition: from Data Collection to Ligand-Based Modeling

1 reference

12 December 2020

The Protein Data Bank: a computer-based archival file for macromolecular structures

1 reference

12 December 2020

Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

1 reference

12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1 reference

12 December 2020

Applying linked data approaches to pharmacology: Architectural decisions and implementation

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.3233/SW-2012-0088

10.1016/J.ADDR.2015.03.001

10 July 2022

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25769815%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25769815%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

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