Clarification of P-glycoprotein inhibition-related drug-drug interaction risks based on a literature search of the clinical information. (Q50668713)

17 March 2018

title

Clarification of P-glycoprotein inhibition-related drug-drug interaction risks based on a literature search of the clinical information. (English)

1 reference

17 March 2018

1 reference

0 references

Yukari Umeyama

1

1 reference

17 March 2018

Yasushi Fujioka

series ordinal

2

1 reference

17 March 2018

Teruaki Okuda

series ordinal

3

1 reference

17 March 2018

language of work or name

English

0 references

publication date

17 June 2014

1 reference

17 March 2018

published in

Xenobiotica

1 reference

17 March 2018

volume

44

1 reference

17 March 2018

issue

12

1 reference

17 March 2018

page(s)

1135-1144

1 reference

17 March 2018

Pharmacokinetics of rifampin and clarithromycin in patients treated for Mycobacterium ulcerans infection.

cites work

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Bilateral pharmacokinetic interaction between cyclosporine A and atorvastatin in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Influence of carvedilol on serum digoxin levels in heart failure: is there any gender difference?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Lack of effect of P-glycoprotein inhibition on renal clearance of dicloxacillin in patients with cystic fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Atazanavir enhances saquinavir hard-gel concentrations in a ritonavir-boosted once-daily regimen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Everolimus exposure in cardiac transplant recipients is influenced by concomitant calcineurin inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatin capsules) administration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of low-dose ritonavir on the pharmacokinetics of the CXCR4 antagonist AMD070 in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Pharmacokinetics of tenofovir disoproxil fumarate and ritonavir-boosted saquinavir mesylate administered alone or in combination at steady state

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Pharmacokinetic interaction between oral lovastatin and verapamil in healthy subjects: role of P-glycoprotein inhibition by lovastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Drug interaction between oral atorvastatin and verapamil in healthy subjects: effects of atorvastatin on the pharmacokinetics of verapamil and norverapamil

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Phase I evaluation of the safety, pharmacokinetics and pharmacodynamics of CP-481,715.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Predicting drug candidate victims of drug-drug interactions, using microdosing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of steady-state atorvastatin on the pharmacokinetics of a single dose of colchicine in healthy adults under fasted conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

A semi-mechanistic absorption model to evaluate drug-drug interaction with dabigatran: application with clarithromycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Influence of erythromycin on the pharmacokinetics of ximelagatran may involve inhibition of P-glycoprotein-mediated excretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Drug-drug interactions mediated through P-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of telaprevir on the pharmacokinetics of midazolam and digoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Membrane transporters in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Pharmacokinetic and safety profile of desloratadine and fexofenadine when coadministered with azithromycin: a randomized, placebo-controlled, parallel-group study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Oral bioavailability of dabigatran etexilate (Pradaxa(®) ) after co-medication with verapamil in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Pharmacokinetic interactions between nelfinavir and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors atorvastatin and simvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam (CYP3A4), fexofenadine (p-glycoprotein), and pravastatin (OATP1B1) as probe drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Pharmacokinetic interactions of maraviroc with darunavir-ritonavir, etravirine, and etravirine-darunavir-ritonavir in healthy volunteers: results of two drug interaction trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of ketoconazole on ritonavir and saquinavir concentrations in plasma and cerebrospinal fluid from patients infected with human immunodeficiency virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Cytochrome P4503A does not mediate the interaction between methadone and ritonavir-lopinavir

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of coadministration of single and multiple doses of rifampicin on the pharmacokinetics of fexofenadine enantiomers in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

The effect of ABCB1 polymorphism on the pharmacokinetics of saquinavir alone and in combination with ritonavir.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Role of cytochrome p450 isoenzymes 3A and 2D6 in the in vivo metabolism of mirabegron, a β3-adrenoceptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of the hepatitis C virus protease inhibitor telaprevir on the pharmacokinetics of amlodipine and atorvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Combined therapy with atorvastatin and calcineurin inhibitors: no interactions with tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effects of clarithromycin and grapefruit juice on the pharmacokinetics of glibenclamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Pharmacokinetic and pharmacodynamic interaction of nadolol with itraconazole, rifampicin and grapefruit juice in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Drug-drug interaction analysis of pyronaridine/artesunate and ritonavir in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: in vivo evidence of involvement of P-glycoprotein in risperidone disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Prednisolone pharmacokinetics in the presence and absence of ritonavir after oral prednisone administration to healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

A randomized, double-blind, pharmacokinetic study of oral maribavir with tacrolimus in stable renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Differential effects of tipranavir plus ritonavir on atorvastatin or rosuvastatin pharmacokinetics in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Area-under-the-curve monitoring of prednisolone for dose optimization in a stable renal transplant population

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of ketoconazole on the pharmacokinetics of ornidazole--a possible role of p-glycoprotein and CYP3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

A study of the pharmacokinetic interaction of istradefylline, a novel therapeutic for Parkinson's disease, and atorvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Rifampin's acute inhibitory and chronic inductive drug interactions: experimental and model-based approaches to drug-drug interaction trial design.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Increased drug delivery to the brain by P-glycoprotein inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Enantioselective disposition of fexofenadine with the P-glycoprotein inhibitor verapamil

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Different effects of the selective serotonin reuptake inhibitors fluvoxamine, paroxetine, and sertraline on the pharmacokinetics of fexofenadine in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effects of itraconazole and diltiazem on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effects of ketoconazole and carbamazepine on lapatinib pharmacokinetics in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Alteration of pharmacokinetics of proguanil in healthy volunteers following concurrent administration of efavirenz

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Potential for pharmacokinetic interactions between ambrisentan and cyclosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Retrospective analysis of P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Predicting drug-drug interactions involving the inhibition of intestinal CYP3A4 and P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Method for predicting the risk of drug-drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

The different effects of itraconazole on the pharmacokinetics of fexofenadine enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Ritonavir increases loperamide plasma concentrations without evidence for P-glycoprotein involvement

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

The effect of gut metabolism on tacrolimus bioavailability in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Transporter studies in drug development: experience to date and follow-up on decision trees from the International Transporter Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Clinically important interaction between tedisamil and verapamil

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Pharmacokinetics of saquinavir, atazanavir, and ritonavir in a twice-daily boosted double-protease inhibitor regimen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of cyclosporine on the pharmacokinetics of colchicine in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of omeprazole on the pharmacokinetics of saquinavir-500 mg formulation with ritonavir in healthy male and female volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Itraconazole and domperidone: a placebo-controlled drug interaction study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Pharmacokinetic Interactions between Sirolimus and Microemulsion Cyclosporine When Orally Administered Jointly and 4 Hours Apart in Healthy Volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

Itraconazole, a P-Glycoprotein and CYP3A4 Inhibitor, Markedly Raises the Plasma Concentrations and Enhances the Renin-Inhibiting Effect of Aliskiren

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2014.928958

10.3109/00498254.2014.928958

21 January 2018

Identifiers

DOI

1 reference

17 March 2018

PubMed ID

24937160

1 reference

17 March 2018