PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation (Q38340031)

2 September 2017

PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation (English)

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2 September 2017

R Deng

1

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2 September 2017

J Tang

2

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2 September 2017

J-G Ma

3

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2 September 2017

S-P Chen

4

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2 September 2017

L-P Xia

5

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2 September 2017

W-J Zhou

6

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2 September 2017

D-D Li

7

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2 September 2017

G-K Feng

8

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2 September 2017

Y-X Zeng

9

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2 September 2017

X-F Zhu

10

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2 September 2017

language of work or name

English

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publication date

18 October 2010

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2 September 2017

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2 September 2017

30

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8

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2 September 2017

944-955

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https://scigraph.springernature.com/pub.10.1038/onc.2010.467

2 September 2017

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Double functions for the Mre11 complex during DNA double-strand break repair and replication

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The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae

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Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

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ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway

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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

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The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

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The Wnt/beta-catenin signaling pathway as a target in drug discovery

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Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

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Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines

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Increased expression of pAKT is associated with radiation resistance in cervical cancer

31 March 2020

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Histone H2AX Phosphorylation as a Predictor of Radiosensitivity and Target for Radiotherapy

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2010.467

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Dimensions Publication ID

2 September 2017

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