SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice. (Q38321332)

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English	SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.	scientific article

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6 January 2020

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice (English)

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6 January 2020

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Haruhisa Iguchi

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Yukio Ikeda

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Masashi Okamura

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Toshiya Tanaka

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Yasuyo Urashima

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Hiroto Ohguchi

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Shinobu Takayasu

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Noriaki Kojima

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Satoshi Iwasaki

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Riuko Ohashi

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Shuying Jiang

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Go Hasegawa

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Ryoichi X Ioka

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Kenta Magoori

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Koichi Sumi

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Takashi Maejima

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Aoi Uchida

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Makoto Naito

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Timothy F Osborne

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Masashi Yanagisawa

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Tokuo T Yamamoto

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Tatsuhiko Kodama

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7 September 2005

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Journal of Biological Chemistry

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37669-37680

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6 January 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats

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Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

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PDX:PBX complexes are required for normal proliferation of pancreatic cells during development

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Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor

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Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.

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10.1074/JBC.M505392200

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