Kinetic evidence for inefficient and error-prone bypass across bulky N2-guanine DNA adducts by human DNA polymerase iota (Q38315115)

2 September 2017

Kinetic evidence for inefficient and error-prone bypass across bulky N2-guanine DNA adducts by human DNA polymerase iota (English)

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2 September 2017

2

F Peter Guengerich

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2 September 2017

Jeong-Yun Choi

1

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PubMed ID

16527824

2 September 2017

language of work or name

English

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publication date

8 March 2006

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

281

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2 September 2017

18

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2 September 2017

12315-12324

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Specialized DNA polymerases, cellular survival, and the genesis of mutations

2 September 2017

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Error-prone repair DNA polymerases in prokaryotes and eukaryotes

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The Y-family of DNA polymerases

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Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function

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Translesional synthesis on a DNA template containing N2-methyl-2'-deoxyguanosine catalyzed by the Klenow fragment of Escherichia coli DNA polymerase I

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Miscoding potential of the N2-ethyl-2'-deoxyguanosine DNA adduct by the exonuclease-free Klenow fragment of Escherichia coli DNA polymerase I.

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Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine.

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Cytochrome P450 activation of arylamines and heterocyclic amines

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Analysis of the effect of bulk at N2-alkylguanine DNA adducts on catalytic efficiency and fidelity of the processive DNA polymerases bacteriophage T7 exonuclease- and HIV-1 reverse transcriptase

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Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta.

21 January 2018

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Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

21 January 2018

1 reference

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Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iota

21 January 2018

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Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota

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Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota

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Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa

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Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing

21 January 2018

1 reference

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Human DNA polymerase iota incorporates dCTP opposite template G via a G.C + Hoogsteen base pair

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Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia.

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The overexpression of specialized DNA polymerases in cancer.

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Altered DNA polymerase iota expression in breast cancer cells leads to a reduction in DNA replication fidelity and a higher rate of mutagenesis

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Interactions of carcinogen-bound DNA with individual DNA polymerases

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Analysis of nucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by replicative T7 polymerase exo- and human immunodeficiency virus-1 reverse transcriptase using steady-state and pre-steady-state kinetics

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Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine

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Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes

21 January 2018

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Kinetics of nucleotide incorporation opposite polycyclic aromatic hydrocarbon-DNA adducts by processive bacteriophage T7 DNA polymerase

21 January 2018

1 reference

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Kinetics of nucleotide incorporation opposite DNA bulky guanine N2 adducts by processive bacteriophage T7 DNA polymerase (exonuclease-) and HIV-1 reverse transcriptase

21 January 2018

1 reference

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Steady-state and pre-steady-state kinetic analysis of 8-oxo-7,8-dihydroguanosine triphosphate incorporation and extension by replicative and repair DNA polymerases

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1 reference

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Biochemical basis of DNA replication fidelity

21 January 2018

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Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

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Rapid quench kinetic analysis of polymerases, adenosinetriphosphatases, and enzyme intermediates

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An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics

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Effect of RNA secondary structure on the kinetics of DNA synthesis catalyzed by HIV-1 reverse transcriptase

21 January 2018

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Explanation of pre-steady-state kinetics and decreased burst amplitude of HIV-1 reverse transcriptase at sites of modified DNA bases with an additional, nonproductive enzyme-DNA-nucleotide complex

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Single d(GpG)/cis-diammineplatinum(II) adduct-induced inhibition of DNA polymerization

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Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom

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Mechanism of DNA polymerization catalyzed by Sulfolobus solfataricus P2 DNA polymerase IV.

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The molecular surface package

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Human DNA polymerase iota utilizes different nucleotide incorporation mechanisms dependent upon the template base.

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Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.

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Human DNA polymerase iota promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA.

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Localisation of human DNA polymerase kappa to replication foci

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Localisation of human Y-family DNA polymerase kappa: relationship to PCNA foci.

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DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint

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Rev1 employs a novel mechanism of DNA synthesis using a protein template

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Effective Utilization ofN2-Ethyl-2‘-deoxyguanosine Triphosphate during DNA Synthesis Catalyzed by Mammalian Replicative DNA Polymerases†

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Double-stranded DNA stereoselectively binds benzo(a)pyrene diol epoxides

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Identifiers

DOI

10.1074/JBC.M600112200

1 reference

2 September 2017

1 reference

PubMed ID

16527824