Base excision repair intermediates as topoisomerase II poisons (Q38295973)

1 September 2017

Base excision repair intermediates as topoisomerase II poisons (English)

1 reference

1 September 2017

Wilstermann AM

1

1 reference

PubMed ID

11591703

1 September 2017

Osheroff N

series ordinal

2

1 reference

PubMed ID

11591703

1 September 2017

language of work or name

English

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publication date

8 October 2001

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Journal of Biological Chemistry

1 September 2017

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1 September 2017

276

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1 September 2017

49

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1 September 2017

46290-46296

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https://api.crossref.org/works/10.1074%2FJBC.M105733200

1 September 2017

1 reference

DNA topoisomerases: structure, function, and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Functional and regulatory characteristics of eukaryotic type II DNA topoisomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Moving one DNA double helix through another by a type II DNA topoisomerase: the story of a simple molecular machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Uncoupling the DNA cleavage and religation activities of topoisomerase II with a single-stranded nucleic acid substrate: evidence for an active enzyme-cleaved DNA intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Mutagenic properties of topoisomerase-targeted drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

DNA topoisomerases as anticancer drug targets: from the laboratory to the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Tumor cell death induced by topoisomerase-targeting drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Apurinic sites are position-specific topoisomerase II poisons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Position-specific effects of base mismatch on mammalian topoisomerase II DNA cleaving activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

DNA glycosylases in the base excision repair of DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Initiation of base excision repair: glycosylase mechanisms and structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

DNA repair mechanisms for the recognition and removal of damaged DNA bases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Cellular responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Base excision repair of DNA in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Base excision repair in yeast and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Characterization of a novel cis-syn and trans-syn-II pyrimidine dimer glycosylase/AP lyase from a eukaryotic algal virus, Paramecium bursaria chlorella virus-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

The catalytic mechanism of a pyrimidine dimer-specific glycosylase (pdg)/abasic lyase, Chlorella virus-pdg

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Mutagenesis by apurinic/apyrimidinic sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Overexpression of enzymes that repair endogenous damage to DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

A method for detecting abasic sites in living cells: age-dependent changes in base excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Repair of oxidative damage to DNA: enzymology and biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

3-methyladenine DNA glycosylases: structure, function, and biological importance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

5'-nicked apurinic/apyrimidinic sites are resistant to beta-elimination by beta-polymerase and are persistent in human cultured cells after oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Positioning the 3'-DNA terminus for topoisomerase II-mediated religation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Rate of depurination of native deoxyribonucleic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Instability and decay of the primary structure of DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Apurinic sites as mutagenic intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Effects of abasic sites and DNA single-strand breaks on prokaryotic RNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

DNA filter elution: a window on DNA damage in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Cell death induced by topoisomerase-targeted drugs: more questions than answers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

The DNA binding, cleavage, and religation reactions of eukaryotic topoisomerases I and II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Secondary leukemias induced by topoisomerase-targeted drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Clinical applications of anticancer drugs targeted to topoisomerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Catalytic inhibitors of DNA topoisomerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Abasic sites stimulate double-stranded DNA cleavage mediated by topoisomerase II. DNA lesions as endogenous topoisomerase II poisons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

The response of eukaryotic topoisomerases to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Spontaneous DNA damage stimulates topoisomerase II-mediated DNA cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Mammalian base excision repair and DNA polymerase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Two Pathways for Base Excision Repair in Mammalian Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105733200

21 January 2018

Identifiers

DOI

10.1074/JBC.M105733200

1 reference

1 September 2017

1 reference

PubMed ID

11591703