Mutagenic properties of topoisomerase-targeted drugs. (Q52531966)

2 May 2018

review article

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title

Mutagenic properties of topoisomerase-targeted drugs. (English)

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2 May 2018

author name string

B C Baguley

series ordinal

1

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2 May 2018

L R Ferguson

series ordinal

2

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2 May 2018

publication date

1 October 1998

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2 May 2018

Biochimica et Biophysica Acta

published in

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2 May 2018

volume

1400

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2 May 2018

page(s)

213-222

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2 May 2018

issue

1-3

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2 May 2018

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Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II.

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Topoisomerase poisons: harnessing the dark side of enzyme mechanism.

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Illegitimate recombination mediated by T4 DNA topoisomerase in vitro. Recombinants between phage and plasmid DNA molecules.

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Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro

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Topoisomerase II enzymes and mutagenicity

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Role of nonhistone proteins in metaphase chromosome structure

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Mitotic chromosome condensation.

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Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus

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Different topoisomerase II antitumor drugs direct similar specific long-range fragmentation of an amplified c-MYC gene locus in living cells and in high-salt-extracted nuclei.

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Topoisomerase II is a structural component of mitotic chromosome scaffolds.

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UVB-induced DNA breaks interfere with transcriptional induction of c-fos

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The 90 kDa heat shock protein (hsp90) induces the condensation of the chromatin structure.

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The effect of heat shock on the morphology of amphibian lampbrush chromosomes.

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Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

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Novel carbamate analogues of amsacrine with activity against non-cycling murine and human tumour cells

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Cellular responses to methyl-N-[4-(9-acridinylamino)-2-methoxyphenyl]carbamate hydrochloride, an analogue of amsacrine active against non-proliferating cells

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Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells

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Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development

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The 180-kDa isoform of topoisomerase II is localized in the nucleolus and belongs to the structural elements of the nucleolar remnant

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Localization of DNA topoisomerase II in Chinese hamster fibroblasts by confocal and electron microscopy

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A carbamate analogue of amsacrine with activity against non-cycling cells stimulates topoisomerase II cleavage at DNA sites distinct from those of amsacrine

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Initiation of DNA replication in eukaryotic cells

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Genes occupy a fixed and symmetrical position on sister chromatids

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DNA topoisomerase-targeting antitumor drugs can be studied in yeast

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Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8

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Relationship between cytotoxicity and site-specific DNA recombination after in vitro exposure of leukemia cells to etoposide

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Etoposide (VP-16-213)-induced gene alterations: potential contribution to cell death

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Cellular and chromosomal hypersensitivity to DNA crosslinking agents and topoisomerase inhibitors in the radiosensitive Chinese hamster irs mutants: phenotypic similarities to ataxia telangiectasia and Fanconi's anaemia cells.

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Different fates of camptothecin-induced replication fork-associated double-strand DNA breaks in mammalian cells

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Sister chromatid separation in frog egg extracts requires DNA topoisomerase II activity during anaphase

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Inhibitors of DNA topoisomerase II prevent chromatid separation in mammalian cells but do not prevent exit from mitosis

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Chromosome recombination and defective genome segregation induced in Chinese hamster cells by the topoisomerase II inhibitor VM-26

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DNA topoisomerase II is required for formation of mitotic chromosomes in Chinese hamster ovary cells: studies using the inhibitor 4'-demethylepipodophyllotoxin 9-(4,6-O-thenylidene-beta-D-glucopyranoside).

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Coming undone: how to untangle a chromosome

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Meiosis-specific arrest revealed in DNA topoisomerase II mutants

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Mutagenicity of anticancer drugs in mammalian germ cells

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Analysis of micronuclei induced in mouse early spermatids by mitomycin C, vinblastine sulfate or etoposide using fluorescence in situ hybridization

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Identifiers

DOI

1 reference

2 May 2018

PubMed ID

9748584

1 reference

2 May 2018