Organic nitrates: update on mechanisms underlying vasodilation, tolerance and endothelial dysfunction (Q38274954)

1 September 2017

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title

Organic nitrates: update on mechanisms underlying vasodilation, tolerance and endothelial dysfunction (English)

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1 September 2017

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Thomas Münzel

1

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PubMed ID

25446162

1 September 2017

Sebastian Steven

series ordinal

2

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PubMed ID

25446162

1 September 2017

Andreas Daiber

series ordinal

3

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1 September 2017

14 October 2014

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1 September 2017

Vascular Pharmacology

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1 September 2017

63

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1 September 2017

3

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1 September 2017

105-113

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2013 ESC guidelines on the management of stable coronary artery disease

1 September 2017

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Counter-regulatory responses to continuous and intermittent therapy with nitroglycerin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Effects of glyceryl trinitrate on endothelium-dependent and -independent relaxation and cyclic GMP levels in rat aorta and human coronary artery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Chronic therapy with isosorbide-5-mononitrate causes endothelial dysfunction, oxidative stress, and a marked increase in vascular endothelin-1 expression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Insights into cGMP signalling derived from cGMP kinase knockout mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Does Nitric Oxide Mediate the Vasodilator Activity of Nitroglycerin?

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Discrepancies between nitroglycerin and NO-releasing drugs on mitochondrial oxygen consumption, vasoactivity, and the release of NO.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Identification of the enzymatic mechanism of nitroglycerin bioactivation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Role of mitochondrial aldehyde dehydrogenase in nitroglycerin-induced vasodilation of coronary and systemic vessels: an intact canine model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Differential metabolism of organic nitrates by aldehyde dehydrogenase 1a1 and 2: substrate selectivity, enzyme inactivation, and active cysteine sites

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

In vitro organic nitrate bioactivation to nitric oxide by recombinant aldehyde dehydrogenase 3A1.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Incidence of early tolerance to hemodynamic effects of continuous infusion of nitroglycerin in patients with coronary artery disease and heart failure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Dissociation of coronary vascular tolerance and neurohormonal adjustments during long-term nitroglycerin therapy in patients with stable coronary artery disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Intermittent transdermal nitroglycerin therapy. Decreased anginal threshold during the nitrate-free interval

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Effects of nitroglycerin treatment on baroreflex sensitivity and short-term heart rate variability in humans

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Desensitization of guanylate cyclase in nitrate tolerance does not impair endothelium-dependent responses

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Continuous therapy with nitroglycerin impairs endothelium-dependent vasodilation but does not cause tolerance in conductance arteries: a human in vivo study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Therapy with nitroglycerin increases coronary vasoconstriction in response to acetylcholine

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Nitroglycerin withdrawal increases endothelium-dependent vasomotor response to acetylcholine.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Nitroglycerin tolerance in human vessels: evidence for impaired nitroglycerin bioconversion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation: a human in vivo study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Platelet nitric oxide and superoxide release during the development of nitrate tolerance: effect of supplemental ascorbate

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Role of reduced lipoic acid in the redox regulation of mitochondrial aldehyde dehydrogenase (ALDH-2) activity. Implications for mitochondrial oxidative stress and nitrate tolerance

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Complex I dysfunction and tolerance to nitroglycerin: an approach based on mitochondrial-targeted antioxidants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Heterozygous deficiency of manganese superoxide dismutase in mice (Mn-SOD+/-): a novel approach to assess the role of oxidative stress for the development of nitrate tolerance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Regulation of human mitochondrial aldehyde dehydrogenase (ALDH-2) activity by electrophiles in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: a human in vivo study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and S-Glutathionylation of endothelial nitric oxide synthase: beneficial effects of therapy with the AT1 receptor blocker telmisartan

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Tetrahydrobiopterin improves endothelium-dependent vasodilation in nitroglycerin-tolerant rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Oxidative stress increases endothelin-1 synthesis in human coronary artery smooth muscle cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Oxidative stress increases synthesis of big endothelin-1 by activation of the endothelin-1 promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Long-term nitroglycerin treatment is associated with supersensitivity to vasoconstrictors in men with stable coronary artery disease: prevention by concomitant treatment with captopril.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans: evidence of a free-radical-mediated mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Long-term nitrate use may be deleterious in ischemic heart disease: A study using the databases from two large-scale postinfarction studies. Multicenter Myocardial Ischemia Research Group

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Comparison of the effects of pentaerythritol tetranitrate and nitroglycerin on endothelium-dependent vasorelaxation in male volunteers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

The nitric oxide donor pentaerythritol tetranitrate can preserve endothelial function in established atherosclerosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Endothelial Protection by Pentaerithrityl Trinitrate: Bilirubin and Carbon Monoxide as Possible Mediators

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Pharmacological induction of vascular extracellular superoxide dismutase expression in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Efficacy of the long-acting nitro vasodilator pentaerithrityl tetranitrate in patients with chronic stable angina pectoris receiving anti-anginal background therapy with beta-blockers: a 12-week, randomized, double-blind, placebo-controlled trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Tolerance to isosorbide dinitrate: rate of development and reversal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Oral isosorbide dinitrate in the treatment of angina pectoris. Dose-response relationship and duration of action during acute therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Tolerance to the circulatory effects of oral isosorbide dinitrate. Rate of development and cross-tolerance to glyceryl trinitrate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Oral isosorbide dinitrate in angina pectoris: comparison of duration of action an dose-response relation during acute and sustained therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Effects of the long-term administration of nicorandil on vascular endothelial function and the progression of arteriosclerosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Combination of isosorbide dinitrate and hydralazine in blacks with heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Nitroso-redox balance in the cardiovascular system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Lack of oxidative stress during sustained therapy with isosorbide dinitrate and pentaerythrityl tetranitrate in healthy humans: a randomized, double-blind crossover study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

More answers to the still unresolved question of nitrate tolerance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Impaired vasodilator response to organic nitrates in isolated basilar arteries

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Cytochrome P450 is responsible for nitric oxide generation from NO-aspirin and other organic nitrates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Effects of pentaerythritol tetranitrate on endothelial function in coronary artery disease: results of the PENTA study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

Nitrate tolerance in epicardial arteries or in the venous system is not reversed by N-acetylcysteine in vivo, but tolerance-independent interactions exist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2014.09.002

10.1016/J.VPH.2014.09.002

7 January 2021

Identifiers

DOI

1 reference

1 September 2017

1 reference

PubMed ID

25446162