Identification of the enzymatic mechanism of nitroglycerin bioactivation (Q34032459)

30 July 2017

Identification of the enzymatic mechanism of nitroglycerin bioactivation (English)

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30 July 2017

Zhiqiang Chen

1

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30 July 2017

Jian Zhang

series ordinal

2

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30 July 2017

Jonathan S Stamler

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

4 June 2002

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

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30 July 2017

99

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30 July 2017

8306-8311

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30 July 2017

12

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Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism.

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Role of disulfiram in the in vitro inhibition of rat liver mitochondrial aldehyde dehydrogenase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Nitrate tolerance is specific for nitric acid esters and its recovery requires an intact protein synthesis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Inhibition of NADPH-cytochrome P450 reductase and glyceryl trinitrate biotransformation by diphenyleneiodonium sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Isoform-specific biotransformation of glyceryl trinitrate by rat aortic glutathione S-transferases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Sulfhydryl requirement for relaxation of vascular smooth muscle

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Erythrocyte aldehyde dehydrogenase and disulfiram-like side effects of hypoglycemics and antianginals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Biotransformation of glyceryl trinitrate occurs concurrently with relaxation of rabbit aorta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Mechanism of glyceryl trinitrate-induced vasodilation. I. Relationship between drug biotransformation, tissue cyclic GMP elevation and relaxation of rabbit aorta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

The preparative isolation of mitochondria from Chinese hamster ovary cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Biotransformation of glyceryl trinitrate and isosorbide dinitrate in vascular smooth muscle made tolerant to organic nitrates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Biotransformation of Glyceryl Trinitrate and Elevation of Cyclic GMP Precede Glyceryl Trinitrate-Induced Vasodilation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

In vitro activation of soluble guanylyl cyclase and nitric oxide release: a comparison of NO donors and NO mimetics

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Mechanism of nitric oxide-induced vasodilatation: refilling of intracellular stores by sarcoplasmic reticulum Ca2+ ATPase and inhibition of store-operated Ca2+ influx.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Novel guanylyl cyclase inhibitor potently inhibits cyclic GMP accumulation in endothelial cells and relaxation of bovine pulmonary artery.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123063

Nicorandil metabolism in rat myocardial mitochondria

29 October 2018

1 reference

12 December 2020

Nitroglycerin tolerance in human vessels: evidence for impaired nitroglycerin bioconversion

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12 December 2020

Does nitroglycerin therapy hit the endothelium?

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12 December 2020

Effects of organic nitrates on mitochondrial respiration and swelling: possible correlations with the mechanism of pharmacologic action

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12 December 2020

Horse liver aldehyde dehydrogenase. II. Kinetics and mechanistic implications of the dehydrogenase and esterase activity

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12 December 2020

Biotransformation of glyceryl trinitrate by rat aortic cytochrome P450

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12 December 2020

Biochemical characterization of a membrane-bound enzyme responsible for generating nitric oxide from nitroglycerin in vascular smooth muscle cells

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12 December 2020

Nitrite ion is not an active intermediate in the vascular metabolism of organic nitrates and organic nitrites to nitric oxide

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12 December 2020

Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels

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12 December 2020

Guanylate cyclase activation by organic nitrates is not mediated via nitrite

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12 December 2020

Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class Mu forms

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12 December 2020

Cytochrome P-450 mediated biotransformation of organic nitrates

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12 December 2020

Inactivation of human aldehyde dehydrogenase by isosorbide dinitrate

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12 December 2020

Endothelial type nitric oxide synthase in skeletal muscle fibers: mitochondrial relationships

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12 December 2020

Mechanism for the inhibition of aldehyde dehydrogenase by nitric oxide

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12 December 2020

Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions

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12 December 2020

Mechanisms of inhibition of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide

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12 December 2020

Nitrite reductase activity is a novel function of mammalian mitochondria

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12 December 2020

Long-term nitrate use may be deleterious in ischemic heart disease: A study using the databases from two large-scale postinfarction studies. Multicenter Myocardial Ischemia Research Group

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12 December 2020

Antagonism of glycerol trinitrate activity by an inhibitor of glutathione S-transferase

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12 December 2020

Preparation and standardization of nitroglycerin injection

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12 December 2020

Reactions of nitric oxide with cytochrome c oxidase

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12 December 2020

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates

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12 December 2020

Isolation and characterization of aldehyde dehydrogenase isozymes from usual and atypical human livers

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12 December 2020

Identifiers

DOI

10.1073/PNAS.122225199

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30 July 2017

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30 July 2017

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