Peptide vectors for gene delivery: from single peptides to multifunctional peptide nanocarriers (Q38269128)

1 September 2017

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title

Peptide vectors for gene delivery: from single peptides to multifunctional peptide nanocarriers (English)

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1 September 2017

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Markus de Raad

1

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PubMed ID

25405798

1 September 2017

Erik A Teunissen

series ordinal

2

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PubMed ID

25405798

1 September 2017

Enrico Mastrobattista

series ordinal

3

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1 September 2017

1 July 2014

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1 September 2017

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1 September 2017

9

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1 September 2017

2217-2232

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1 September 2017

14

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Library selection and directed evolution approaches to engineering targeted viral vectors

1 September 2017

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Artificial viruses: exploiting viral trafficking for therapeutics

21 January 2018

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Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

21 January 2018

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Artificial viruses: a nanotechnological approach to gene delivery

21 January 2018

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Barriers to gene delivery using synthetic vectors.

21 January 2018

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Extracellular barriers to in Vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver

21 January 2018

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Actin cytoskeleton as the principal determinant of size-dependent DNA mobility in cytoplasm: a new barrier for non-viral gene delivery

21 January 2018

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Prospects for cationic polymers in gene and oligonucleotide therapy against cancer

21 January 2018

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The nuclear pore complex: the gateway to successful nonviral gene delivery

21 January 2018

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Targeted delivery to the nucleus.

21 January 2018

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Getting across the nuclear pore complex

21 January 2018

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Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm

21 January 2018

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Nucleic-acid based gene therapeutics: delivery challenges and modular design of nonviral gene carriers and expression cassettes to overcome intracellular barriers for sustained targeted expression

21 January 2018

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Peptide-mediated DNA condensation for non-viral gene therapy.

21 January 2018

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Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses.

21 January 2018

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Peptide vectors for the nonviral delivery of nucleic acids

21 January 2018

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Peptides in DNA delivery: current insights and future directions

21 January 2018

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Therapeutic peptides: technological advances driving peptides into development

21 January 2018

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Improved gene expression using low molecular weight peptides produced from protamine sulfate.

21 January 2018

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A vascular endothelial growth factor high affinity receptor 1-specific peptide with antiangiogenic activity identified using a phage display peptide library

21 January 2018

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Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle

21 January 2018

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Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells

21 January 2018

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Recent Developments in Peptide-Based Nucleic Acid Delivery

21 January 2018

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Calcitonin-derived peptide carriers: mechanisms and application

21 January 2018

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Peptide-guided gene delivery

21 January 2018

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A peptide-based vector for efficient gene transfer in vitro and in vivo

21 January 2018

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Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery

21 January 2018

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Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape

21 January 2018

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Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes

21 January 2018

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Modular protein engineering for non-viral gene therapy.

21 January 2018

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Synthetic DNA-compacting peptides derived from human sequence enhance cationic lipid-mediated gene transfer in vitro and in vivo.

21 January 2018

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Kinetic study of DNA condensation by cationic peptides used in nonviral gene therapy: analogy of DNA condensation to protein folding

21 January 2018

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Low molecular weight disulfide cross-linking peptides as nonviral gene delivery carriers

21 January 2018

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Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles

21 January 2018

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Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation.

21 January 2018

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Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy

21 January 2018

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Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function.

21 January 2018

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Translocation activity of C-terminal domain of pestivirus Erns and ribotoxin L3 loop

21 January 2018

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Histidine-rich amphipathic peptide antibiotics promote efficient delivery of DNA into mammalian cells

21 January 2018

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New basic membrane-destabilizing peptides for plasmid-based gene delivery in vitro and in vivo

21 January 2018

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Translocating proline-rich peptides from the antimicrobial peptide bactenecin 7.

21 January 2018

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A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids

21 January 2018

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Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers.

21 January 2018

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Lysosome-disrupting peptide increases the efficiency of in-vivo gene transfer by liposome-encapsulated DNA.

21 January 2018

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Complexes of plasmid DNA with basic domain 47-57 of the HIV-1 Tat protein are transferred to mammalian cells by endocytosis-mediated pathways.

21 January 2018

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Cell-penetrating peptides for the delivery of nucleic acids

21 January 2018

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Peptide nanoparticles for oligonucleotide delivery

21 January 2018

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Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

21 January 2018

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A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy

21 January 2018

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Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells

21 January 2018

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Self-assembling peptide-based nanoparticles for siRNA delivery in primary cell lines.

21 January 2018

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New sequence-defined polyaminoamides with tailored endosomolytic properties for plasmid DNA delivery

21 January 2018

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Peptide-assisted traffic engineering for nonviral gene therapy.

21 January 2018

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Molecular motors as drug delivery vehicles

21 January 2018

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An E3-14.7K peptide that promotes microtubules-mediated transport of plasmid DNA increases polyplexes transfection efficiency

21 January 2018

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Dynein light chain association sequences can facilitate nuclear protein import

21 January 2018

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A cytoplasm-sensitive peptide vector cross-linked with dynein light chain association sequence (DLCAS) enhances gene expression.

21 January 2018

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Engineering nuclear localization signals in modular protein vehicles for gene therapy

21 January 2018

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Nuclear delivery of macromolecules: barriers and carriers.

21 January 2018

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Nucleocytoplasmic transport of DNA: enhancing non-viral gene transfer.

21 January 2018

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Utilization of synthetic peptides containing nuclear localization signals for nonviral gene transfer systems

21 January 2018

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An NLS peptide covalently linked to linear DNA does not enhance transfection efficiency of cationic polymer based gene delivery systems

21 January 2018

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Cell division responsive peptides for optimized plasmid DNA delivery: the mitotic window of opportunity?

21 January 2018

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Strategies in the design of nanoparticles for therapeutic applications

21 January 2018

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Targeting of Synthetic Gene Delivery Systems

21 January 2018

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Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

21 January 2018

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Novel challenges in exploring peptide ligands and corresponding tissue-specific endothelial receptors

21 January 2018

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Transvascular delivery of small interfering RNA to the central nervous system.

21 January 2018

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Selective targeting of cancer cells using synthetic peptides

21 January 2018

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From combinatorial chemistry to cancer-targeting peptides

21 January 2018

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A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo

21 January 2018

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De novo design of a tumor-penetrating peptide

21 January 2018

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Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs

21 January 2018

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Tissue-penetrating delivery of compounds and nanoparticles into tumors

21 January 2018

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Phase I/II trial of a dendritic cell vaccine transfected with DNA encoding melan A and gp100 for patients with metastatic melanoma.

21 January 2018

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A new peptide vector for efficient delivery of oligonucleotides into mammalian cells.

21 January 2018

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A designer biomimetic vector with a chimeric architecture for targeted gene transfer

21 January 2018

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Recombinant fusion proteins TAT-Mu, Mu and Mu-Mu mediate efficient non-viral gene delivery

21 January 2018

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Targeting human epidermal growth factor receptor 2 by a cell-penetrating peptide-affibody bioconjugate

21 January 2018

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Construction of cell penetrating peptide vectors with N-terminal stearylated nuclear localization signal for targeted delivery of DNA into the cell nuclei

21 January 2018

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Designed multi-domain protein as a carrier of nucleic acids into cells

21 January 2018

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A multi-domain protein for beta1 integrin-targeted DNA delivery.

21 January 2018

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A multi-domain protein system based on the HC fragment of tetanus toxin for targeting DNA to neuronal cells

21 January 2018

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Evaluation of the effect of vector architecture on DNA condensation and gene transfer efficiency

21 January 2018

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Construction, expression and characterization of a chimeric multi-domain protein mediating specific DNA transfer

21 January 2018

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Target cell-specific DNA transfer mediated by a chimeric multidomain protein. Novel non-viral gene delivery system

21 January 2018

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Delivery of nucleic acid into mammalian cells by anthrax toxin.

21 January 2018

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Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins

21 January 2018

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Cell-penetrating DNA-binding protein as a safe and efficient naked DNA delivery carrier in vitro and in vivo.

21 January 2018

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EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins

21 January 2018

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Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein

21 January 2018

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Gene transfer into mammalian cells using histone-condensed plasmid DNA.

21 January 2018

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Generation and characterization of a fusion protein of single-chain fragment variable antibody against hemagglutinin antigen of avian influenza virus and truncated protamine

21 January 2018

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A chimeric fusion protein containing transforming growth factor-alpha mediates gene transfer via binding to the EGF receptor

21 January 2018

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A modular DNA carrier protein based on the structure of diphtheria toxin mediates target cell-specific gene delivery

21 January 2018

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Multifunctional protein nanocarriers for targeted nuclear gene delivery in nondividing cells

21 January 2018

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Biosynthesis and characterization of a novel genetically engineered polymer for targeted gene transfer to cancer cells

21 January 2018

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Development of a genetically engineered biomimetic vector for targeted gene transfer to breast cancer cells.

21 January 2018

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Fusion protein linkers: property, design and functionality

21 January 2018

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BglBricks: A flexible standard for biological part assembly

21 January 2018

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A solid-phase platform for combinatorial and scarless multipart gene assembly.

21 January 2018

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A modular cloning system for standardized assembly of multigene constructs

21 January 2018

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Automated purification of recombinant proteins: combining high-throughput with high yield.

21 January 2018

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High-content screening of peptide-based non-viral gene delivery systems.

21 January 2018

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Long synthetic peptides for the production of vaccines and drugs: a technological platform coming of age.

21 January 2018

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Sequential native peptide ligation strategies for total chemical protein synthesis.

21 January 2018

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Chemical methods for peptide and protein production.

21 January 2018

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A native chemical ligation approach for combinatorial assembly of affibody molecules

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/NNM.14.90

1 reference

1 September 2017

1 reference

PubMed ID

25405798