Targeting the Angiopoietin-2/Tie-2 axis in conjunction with VEGF signal interference (Q38259982)

5 October 2017

1 reference

title

Targeting the Angiopoietin-2/Tie-2 axis in conjunction with VEGF signal interference (English)

1 reference

5 October 2017

Nikolett M Biel

1

1 reference

5 October 2017

Dietmar W Siemann

series ordinal

2

1 reference

5 October 2017

language of work or name

English

0 references

publication date

12 October 2014

1 reference

5 October 2017

9

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inferred from page(s)

published in

Cancer Letters

1 reference

5 October 2017

380

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5 October 2017

2

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5 October 2017

525-533

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CP-673451, a platelet-derived growth-factor receptor inhibitor, suppresses lung cancer cell proliferation and migration

5 October 2017

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Combining Bevacizumab with Radiation or Chemoradiation for Solid Tumors: A Review of the Scientific Rationale, and Clinical Trials

23 June 2018

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Exogenous administration of protease-resistant, non-matrix-binding IGFBP-2 inhibits tumour growth in a murine model of breast cancer.

23 June 2018

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Suppression of angiogenesis and tumor growth in vitro and in vivo using an anti-angiopoietin-2 single-chain antibody

23 June 2018

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Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

23 June 2018

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Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy

23 June 2018

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Structural basis for angiopoietin-1-mediated signaling initiation

23 June 2018

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VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

23 June 2018

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Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms

23 June 2018

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Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies

23 June 2018

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Enhanced antitumor efficacy of a vascular disrupting agent combined with an antiangiogenic in a rat liver tumor model evaluated by multiparametric MRI

23 June 2018

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Side effects of anti-angiogenic drugs

23 June 2018

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Targeting the Notch pathway: twists and turns on the road to rational therapeutics

23 June 2018

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Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

23 June 2018

1 reference

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VEGF inhibition, hypertension, and renal toxicity

23 June 2018

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Anti-VEGF/VEGFR therapy for cancer: reassessing the target

23 June 2018

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Inhibition of endothelial/smooth muscle cell contact loss by the investigational angiopoietin-2 antibody MEDI3617.

23 June 2018

1 reference

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MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models

23 June 2018

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FGF receptor inhibitors: role in cancer therapy

23 June 2018

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Potent inhibition of angiogenesis by the IGF-1 receptor-targeting antibody SCH717454 is reversed by IGF-2.

23 June 2018

1 reference

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Anti-angiogenic therapy: concept to clinic

23 June 2018

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Bevacizumab in the treatment of metastatic breast cancer: friend or foe?

23 June 2018

1 reference

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Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Prognostic significance of vascular endothelial growth factor expression in gastric carcinoma: a meta-analysis

23 June 2018

1 reference

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Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates

23 June 2018

1 reference

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TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

23 June 2018

1 reference

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Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer.

23 June 2018

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Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

23 June 2018

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Chemical generation of bispecific antibodies

23 June 2018

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Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody

23 June 2018

1 reference

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Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage

23 June 2018

1 reference

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The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents

23 June 2018

1 reference

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PlGF blockade does not inhibit angiogenesis during primary tumor growth

23 June 2018

1 reference

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Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands

23 June 2018

1 reference

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Pathways mediating VEGF-independent tumor angiogenesis

23 June 2018

1 reference

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Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface

23 June 2018

1 reference

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Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels

23 June 2018

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Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

23 June 2018

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Prognostic value of vascular endothelial growth factor expression in patients with lung cancer: a systematic review with meta-analysis

23 June 2018

1 reference

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Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy.

23 June 2018

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The role of the Angiopoietins in vascular morphogenesis.

23 June 2018

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Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis

23 June 2018

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Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system

23 June 2018

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Dual targeting of tumor vasculature: combining Avastin and vascular disrupting agents (CA4P or OXi4503).

23 June 2018

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Modes of resistance to anti-angiogenic therapy

23 June 2018

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Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1

23 June 2018

1 reference

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Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

23 June 2018

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The role of hypoxia-inducible factors in tumorigenesis.

23 June 2018

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Delta-like 4/Notch signaling and its therapeutic implications

23 June 2018

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Shear stress-induced activation of the AMP-activated protein kinase regulates FoxO1a and angiopoietin-2 in endothelial cells.

23 June 2018

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Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications

23 June 2018

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The role of the EGFR signaling in tumor microenvironment.

23 June 2018

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Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization.

23 June 2018

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PDGF receptors as targets in tumor treatment

23 June 2018

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Angiogenesis: an organizing principle for drug discovery?

23 June 2018

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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

23 June 2018

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Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

23 June 2018

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Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies.

23 June 2018

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Angiopoietins in malignancy

23 June 2018

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Drug penetration in solid tumours

23 June 2018

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Antiangiogenic therapy for cancer: current and emerging concepts

23 June 2018

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Differentiation and definition of vascular-targeted therapies.

23 June 2018

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Epidermal growth factor receptor in tumor angiogenesis

23 June 2018

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Angiopoietin 2 expression is related to histological grade, vascular density, metastases, and outcome in prostate cancer

23 June 2018

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Vascular-targeting therapies for treatment of malignant disease.

23 June 2018

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Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

23 June 2018

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Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysis

23 June 2018

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Concept, mechanisms and therapeutics of angiogenesis in cancer and other diseases

23 June 2018

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The biology of VEGF and its receptors

23 June 2018

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The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2.

23 June 2018

1 reference

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Mechanisms of normal and tumor-derived angiogenesis

23 June 2018

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Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells

23 June 2018

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Angiopoietin and Tie signaling pathways in vascular development

23 June 2018

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Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma

23 June 2018

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Mechanisms of angiogenesis and arteriogenesis

23 June 2018

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Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis

23 June 2018

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VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells

23 June 2018

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Angiopoietins 3 and 4: diverging gene counterparts in mice and humans

23 June 2018

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Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

23 June 2018

1 reference

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Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells

23 June 2018

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Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

23 June 2018

1 reference

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Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

23 June 2018

1 reference

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Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

23 June 2018

1 reference

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

23 June 2018

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Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Endothelial cell proliferation as a novel approach to targeting tumour therapy

23 June 2018

1 reference

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Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

23 June 2018

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Tumor angiogenesis: therapeutic implications

23 June 2018

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Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

23 June 2018

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Vascular endothelial growth factor is a secreted angiogenic mitogen

23 June 2018

1 reference

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A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains

23 June 2018

1 reference

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Can vascular endothelial growth factor and microvessel density be used as prognostic biomarkers for colorectal cancer? A systematic review and meta-analysis.

23 June 2018

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Phase I trial of combretastatin A4 phosphate (CA4P) in combination with bevacizumab in patients with advanced cancer.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Angiopoietin-2 TIEs up macrophages in tumor angiogenesis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Angiopoietin-2 promotes disease progression of neuroendocrine tumors

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

The angiopoietin 1/angiopoietin 2 balance as a prognostic marker in primary glioblastoma multiforme.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Serum angiopoietin-2 as a clinical marker for lung cancer.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Efficacy of combined antiangiogenic and vascular disrupting agents in treatment of solid tumors

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394020

Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration

31 August 2018

1 reference

12 December 2020

Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathway

1 reference

12 December 2020

Vascular Endothelium as the Vulnerable Element in Tumours

1 reference

12 December 2020

Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition

1 reference

12 December 2020

Antiangiogenic therapy: a universal chemosensitization strategy for cancer?

1 reference

12 December 2020

Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells

1 reference

12 December 2020

Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells

1 reference

12 December 2020

10.1016/J.CANLET.2014.09.035

Identifiers

DOI

1 reference

5 October 2017

1 reference

5 October 2017

PubMed publication ID

25312939

1 reference