The biology of VEGF and its receptors (Q27860704)

Europe PubMed Central

title

The biology of VEGF and its receptors (English)

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author

Napoleone Ferrara

1

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Napoleone Ferrara

1

object named as

Napoleone Ferrara

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author name string

Hans-Peter Gerber

2

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Jennifer LeCouter

https://scigraph.springernature.com/pub.10.1038/nm0603-669

3

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language of work or name

English

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publication date

June 2003

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published in

Nature Medicine

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volume

9

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page(s)

669-76

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issue

6

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exact match

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cites work

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VEGF and the quest for tumour angiogenesis factors

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Clinical applications of angiogenic growth factors and their inhibitors

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Mechanisms of angiogenesis and arteriogenesis

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The biology of vascular endothelial growth factor

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7 January 2021

Vascular endothelial growth factor (VEGF) and its receptors

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7 January 2021

Lymphatic endothelium: a new frontier of metastasis research

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7 January 2021

Vascular endothelial growth factor is a secreted angiogenic mitogen

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7 January 2021

Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

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7 January 2021

Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis

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7 January 2021

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

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7 January 2021

Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells

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7 January 2021

Thyroid hormone negatively regulates the transcriptional activity of the beta-amyloid precursor protein gene

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7 January 2021

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

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7 January 2021

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

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7 January 2021

Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration

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7 January 2021

Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor

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7 January 2021

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

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7 January 2021

Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells.

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https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

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https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

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7 January 2021

Experimentally induced changes in the endocytic traffic of P-glycoprotein alter drug resistance of cancer cells

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7 January 2021

Effects of vascular endothelial growth factor on hemodynamics and cardiac performance

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7 January 2021

The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA.

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7 January 2021

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

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7 January 2021

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

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https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency

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https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Signal transduction to hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.

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https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

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https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Oxygen sensors and angiogenesis

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https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

HIF hydroxylation and the mammalian oxygen-sensing pathway

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells

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https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells

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https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

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https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor

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https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Flt-1, a receptor for vascular endothelial growth factor, has transforming and morphogenic potentials.

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Vascular endothelial growth factor is expressed in rat corpus luteum

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Vascular endothelial growth factor is essential for corpus luteum angiogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Identification of an angiogenic mitogen selective for endocrine gland endothelium

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Tumor induction of VEGF promoter activity in stromal cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

VEGF-Trap: a VEGF blocker with potent antitumor effects

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

The role of VEGF in normal and neoplastic hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment.

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

HIF-1alpha is essential for myeloid cell-mediated inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

VEGF and flt. Expression time kinetics in rat brain infarct.

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids.

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Clinical translation of angiogenesis inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021

Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

1 reference

https://api.crossref.org/works/10.1038%2FNM0603-669

7 January 2021