Hedgehog signaling pathway as key player in liver fibrosis: new insights and perspectives (Q38220772)

31 August 2017

Hedgehog signaling pathway as key player in liver fibrosis: new insights and perspectives (English)

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31 August 2017

Jing-Jing Yang

1

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31 August 2017

Hui Tao

series ordinal

2

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31 August 2017

Jun Li

series ordinal

3

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31 August 2017

language of work or name

English

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publication date

17 June 2014

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Expert Opinion on Therapeutic Targets

31 August 2017

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31 August 2017

18

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31 August 2017

1011-1021

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31 August 2017

9

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The therapeutic effects of bone marrow-derived mesenchymal stem cells and simvastatin in a rat model of liver fibrosis.

31 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Nuclear erythroid 2-related factor 2: a novel potential therapeutic target for liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

The significance of YKL-40 protein in liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Mechanisms of hepatic fibrogenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Mechanisms of hepatic fibrogenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

The alpha 2 chain of collagen type VI sequesters latent proforms of matrix-metalloproteinases and modulates their activation and activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hepatic PPARs: their role in liver physiology, fibrosis and treatment

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2014.927443

New surprises of suppressor of cytokine signalling in liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Pathogenesis of liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

A polymorphism that delays fibrosis in hepatitis C promotes alternative splicing of AZIN1, reducing fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Paeoniae radix reduces PDGF-stimulated hepatic stellate cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Th2-associated alternative Kupffer cell activation promotes liver fibrosis without inducing local inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hepatitis B virus X protein stimulates the Hedgehog-Gli activation through protein stabilization and nuclear localization of Gli1 in liver cancer cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Purinergic signaling in wound healing and airway remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Liver fibrosis in elderly cadavers: localization of collagen types I, III, and IV, α-smooth muscle actin, and elastic fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Digital image analysis of collagen assessment of progression of fibrosis in recurrent HCV after liver transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Phosphodiesterase inhibition mediates matrix metalloproteinase activity and the level of collagen degradation fragments in a liver fibrosis ex vivo rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hepatic regeneration and the epithelial to mesenchymal transition

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Retracted: High Mobility Group Box-1 Promotes the Proliferation and Migration of Hepatic Stellate Cells via TLR4-Dependent Signal Pathways of PI3K/Akt and JNK

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

MicroRNA-21 activates hepatic stellate cells via PTEN/Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

The potential of microRNAs in liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

The role of dystroglycan in PDGF-BB-dependent migration of activated hepatic stellate cells/myofibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Thiol redox systems and protein kinases in hepatic stellate cell regulatory processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Carbon monoxide induces hypothermia tolerance in Kupffer cells and attenuates liver ischemia/reperfusion injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Transforming growth factor-α attenuates hepatic fibrosis: possible involvement of matrix metalloproteinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Association of TIMP-1 and TIMP-2 gene polymorphisms with progression of liver fibrosis in patients with type C chronic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Anandamide induces cell death through lipid rafts in hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Effect of bioactive peptide of Carapax Trionycis on TGF-β1-induced intracellular events in hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells: in vivo and in vitro studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog signaling in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

The antihepatic fibrotic effects of fluorofenidone via MAPK signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog signaling in gastric physiology and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Umbilical cord blood cells regulate endogenous neural stem cell proliferation via hedgehog signaling in hypoxic ischemic neonatal rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

The mechanisms of Hedgehog signalling and its roles in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

New prospects for drug development: the hedgehog pathway revealed. Focus on hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog signaling and the Gli code in stem cells, cancer, and metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog signaling and gastrointestinal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog signaling pathway and cancer therapeutics: progress to date

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Molecular pathways: the hedgehog signaling pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog pathway signaling in cervical carcinoma and outcome after chemoradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Role for hedgehog pathway in regulating growth and function of invariant NKT cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Associating portal congestive gastropathy and hepatic fibrosis in hepatosplenic mansoni schistosomiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

The role of Hedgehog signaling in fibrogenic liver repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Inhibition of Notch signaling by a γ-secretase inhibitor attenuates hepatic fibrosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog controls hepatic stellate cell fate by regulating metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Short-course preoperative radiotherapy combined with chemotherapy in resectable locally advanced rectal cancer: local control and quality of life.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Hedgehog signaling regulates the repair response in mouse liver damaged by irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

DNA methylation: new therapeutic implications for hepatic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Morphogens and hepatic stellate cell fate regulation in chronic liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Epigenetic repression of matrix metalloproteinases in myofibroblastic hepatic stellate cells through histone deacetylases 4: implication in tissue fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Recognition of methylated DNA through methyl-CpG binding domain proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

DNA methylation and MeCP2 regulation of PTCH1 expression during rats hepatic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Protective role of estrogen-induced miRNA-29 expression in carbon tetrachloride-induced mouse liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.927443

10.1517/14728222.2014.927443

21 January 2018

Identifiers

DOI

1 reference

31 August 2017

1 reference