PI3K/AKT signaling pathway and cancer: an updated review (Q38217651)

31 August 2017

PI3K/AKT signaling pathway and cancer: an updated review (English)

1 reference

31 August 2017

5

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6 June 2020

Miriam Martini

1

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6 June 2020

Maria Chiara De Santis

2

1 reference

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6 June 2020

Federico Gulluni

4

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Maria Laura Braccini Fagundes

6 June 2020

3

object named as

Laura Braccini

1 reference

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6 June 2020

language of work or name

English

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publication date

5 June 2014

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31 August 2017

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6 June 2020

volume

46

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6 June 2020

page(s)

372-383

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6 June 2020

issue

6

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Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

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21 January 2018

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The analysis of PIK3CA mutations in gastric carcinoma and metanalysis of literature suggest that exon-selectivity is a signature of cancer type.

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Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

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A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition

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Colorectal cancer: mutations in a signalling pathway

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Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

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Deregulated Akt3 activity promotes development of malignant melanoma

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COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

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Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

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The genetic basis of kidney cancer: a metabolic disease

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Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers

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Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

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Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial.

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PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17.

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PIK3CA mutation is associated with poor survival among patients with metastatic colorectal cancer following anti-EGFR monoclonal antibody therapy: a meta-analysis

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PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis

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A phase I trial of liposomal doxorubicin, bevacizumab, and temsirolimus in patients with advanced gynecologic and breast malignancies

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PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations

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PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials

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Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

21 January 2018

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Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors

21 January 2018

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Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.

21 January 2018

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LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer

21 January 2018

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Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

21 January 2018

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Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models

21 January 2018

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PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs

21 January 2018

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KRASness and PIK3CAness in patients with advanced colorectal cancer: outcome after treatment with early-phase trials with targeted pathway inhibitors

21 January 2018

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Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials.

21 January 2018

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RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

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Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition

21 January 2018

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Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements

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Tumor genetic testing for patient selection in phase I clinical trials: the case of PI3K inhibitors.

21 January 2018

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Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer

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21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2014.912836

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and ro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

PI3-kinase inhibitors in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

Idelalisib and rituximab in relapsed chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245408 (XL147), an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.912836

10.3109/07853890.2014.912836

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24897931%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference