Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations (Q38213482)

31 August 2017

Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations (English)

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31 August 2017

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1

Rita Bernhardt

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31 August 2017

Vlada B Urlacher

2

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PubMed ID

24848420

31 August 2017

language of work or name

English

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publication date

22 May 2014

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Applied Microbiology and Biotechnology

31 August 2017

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31 August 2017

98

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31 August 2017

14

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31 August 2017

6185-6203

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https://scigraph.springernature.com/pub.10.1007/s00253-014-5767-7

31 August 2017

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Functional characterization of Fdx1: evidence for an evolutionary relationship between P450-type and ISC-type ferredoxins.

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Adrenodoxin--a versatile ferredoxin

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Challenges and pitfalls of P450-dependent (+)-valencene bioconversion by Saccharomyces cerevisiae.

21 January 2018

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Extending the capabilities of nature's most versatile catalysts: directed evolution of mammalian xenobiotic-metabolizing P450s.

21 January 2018

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Engineering cytochrome p450 enzymes

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Exploiting the versatility of human cytochrome P450 enzymes: the promise of blue roses from biotechnology

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Characterization of the versatile monooxygenase CYP109B1 from Bacillus subtilis

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Coexpression of redox partners increases the hydrocortisone (cortisol) production efficiency in CYP11B1 expressing fission yeast Schizosaccharomyces pombe

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Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1

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Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1: enzymes and catalysis

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Assembly of non-natural electron transfer conduits in the cytochrome P450 system: a critical assessment and update of artificial redox constructs amenable to exploitation in biotechnological areas

21 January 2018

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Steroids, the steroid community, and Upjohn in perspective: a profile of innovation

21 January 2018

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Cloning and expression of cytochrome P450 genes controlling flower colour.

21 January 2018

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Application of computer to monitoring and control of fermentation process: Microbial conversion of ML-236B Na to pravastatin.

21 January 2018

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21 January 2018

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The monooxygenase, peroxidase, and peroxygenase properties of cytochrome P450.

21 January 2018

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21 January 2018

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A novel sterol 14alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily

21 January 2018

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Design and characterization of an efficient CYP105A1-based whole-cell biocatalyst for the conversion of resin acid diterpenoids in permeabilized Escherichia coli.

21 January 2018

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NADPH-flavodoxin reductase and flavodoxin from Escherichia coli: characteristics as a soluble microsomal P450 reductase.

21 January 2018

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Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis

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Light-driven cytochrome p450 hydroxylations.

21 January 2018

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Light-driven chemical synthesis

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Synthesis of vitamin D3 and related compounds

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Engineering of the rose flavonoid biosynthetic pathway successfully generated blue-hued flowers accumulating delphinidin

21 January 2018

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Regioselective hydroxylation of norisoprenoids by CYP109D1 from Sorangium cellulosum So ce56.

21 January 2018

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The construction and characterization of self-sufficient lanosterol 14-demethylase fusion proteins consisting of yeast CYP51 and its reductase

21 January 2018

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21 January 2018

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Use of directed evolution of mammalian cytochromes P450 for investigating the molecular basis of enzyme function and generating novel biocatalysts

21 January 2018

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Expression and characterization of the two flavodoxin proteins of Bacillus subtilis, YkuN and YkuP: biophysical properties and interactions with cytochrome P450 BioI.

21 January 2018

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21 January 2018

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Theoretical and experimental evaluation of a CYP106A2 low homology model and production of mutants with changed activity and selectivity of hydroxylation

21 January 2018

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Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes.

21 January 2018

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Mechanistic enzymology of oxygen activation by the cytochromes P450.

21 January 2018

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Molecular cloning and expression of fatty acid alpha-hydroxylase from Sphingomonas paucimobilis.

21 January 2018

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Enantioselective intramolecular C-H amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo

21 January 2018

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Functionalization of the cytochrome P450cam monooxygenase system in the cell-like aqueous compartments of water-in-oil emulsions

21 January 2018

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A recombinant Escherichia coli whole cell biocatalyst harboring a cytochrome P450cam monooxygenase system coupled with enzymatic cofactor regeneration.

21 January 2018

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21 January 2018

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Coexpression of CPR from various origins enhances biotransformation activity of human CYPs in S. pombe.

21 January 2018

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Changing the regioselectivity of a P450 from C15 to C11 hydroxylation of progesterone.

21 January 2018

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Hydrogen peroxide-mediated dealkylation of 7-ethoxycoumarin by cytochrome P450 (CYP107AJ1) from Streptomyces peucetius ATCC27952.

21 January 2018

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Functional expression system for cytochrome P450 genes using the reductase domain of self-sufficient P450RhF from Rhodococcus sp. NCIMB 9784.

21 January 2018

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Plant biochemistry: anthocyanin biosynthesis in roses.

21 January 2018

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EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme

21 January 2018

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Occurrence and biological function of cytochrome P450 monooxygenases in the actinomycetes

21 January 2018

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Ferredoxins from two sulfonylurea herbicide monooxygenase systems in Streptomyces griseolus

21 January 2018

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Contribution of cytochrome P450 to the diversification of eukaryotic organisms

21 January 2018

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Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450.

21 January 2018

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High-level semi-synthetic production of the potent antimalarial artemisinin

21 January 2018

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Bioconversion of compactin into pravastatin by Streptomyces sp.

21 January 2018

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Microbiological Transformations of Steroids.1I. Introduction of Oxygen at Carbon-11 of Progesterone

21 January 2018

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P450BM-3; a tale of two domains--or is it three?

21 January 2018

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Diversity of P450 enzymes in the biosynthesis of natural products

21 January 2018

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Enzymes involved in the activation and inactivation of vitamin D.

21 January 2018

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Efficient screening of cytochrome P450 BM3 mutants for their metabolic activity and diversity toward a wide set of drug-like molecules in chemical space

21 January 2018

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Chemo-enzymatic fluorination of unactivated organic compounds

21 January 2018

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Production of the antimalarial drug precursor artemisinic acid in engineered yeast

21 January 2018

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Identification of a new class of cytochrome P450 from a Rhodococcus sp.

21 January 2018

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Engineering Macaca fascicularis cytochrome P450 2C20 to reduce animal testing for new drugs.

21 January 2018

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An explosive-degrading cytochrome P450 activity and its targeted application for the phytoremediation of RDX.

21 January 2018

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LICRED: a versatile drop-in vector for rapid generation of redox-self-sufficient cytochrome P450s

21 January 2018

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Chimeric P450 enzymes: activity of artificial redox fusions driven by different reductases for biotechnological applications.

21 January 2018

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Breakthrough in P450 bioelectrochemistry and future perspectives.

21 January 2018

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Bioconversion of vitamin D to its active form by bacterial or mammalian cytochrome P450.

21 January 2018

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Thermostabilization of a cytochrome p450 peroxygenase.

21 January 2018

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Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1.

21 January 2018

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Improvement of P450(BM-3) whole-cell biocatalysis by integrating heterologous cofactor regeneration combining glucose facilitator and dehydrogenase in E. coli

21 January 2018

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P450(BM-3)-catalyzed whole-cell biotransformation of alpha-pinene with recombinant Escherichia coli in an aqueous-organic two-phase system

21 January 2018

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Bacterial (CYP101) and mitochondrial P450 systems-how comparable are they?

21 January 2018

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The interaction of bovine adrenodoxin with CYP11A1 (cytochrome P450scc) and CYP11B1 (cytochrome P45011beta ). Acceleration of reduction and substrate conversion by site-directed mutagenesis of adrenodoxin.

21 January 2018

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Cytochrome P450 (CYP) enzymes and the development of CYP biosensors

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21 January 2018

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21 January 2018

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Electrochemistry of cytochromes p450: analysis of current-voltage characteristics of electrodes with immobilized cytochromes p450 for the screening of substrates and inhibitors.

21 January 2018

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Putidaredoxin reductase-putidaredoxin-cytochrome p450cam triple fusion protein. Construction of a self-sufficient Escherichia coli catalytic system.

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Development of a whole-cell biocatalyst co-expressing P450 monooxygenase and glucose dehydrogenase for synthesis of epoxyhexane.

21 January 2018

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Direct oxidation of cycloalkanes to cycloalkanones with oxygen in water

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Molecular dynamics simulations give insight into the conformational change, complex formation, and electron transfer pathway for cytochrome P450 reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Total biosynthesis of hydrocortisone from a simple carbon source in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Cytochrome P450 monooxygenases: perspectives for synthetic application

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Cytochrome P450 alkane hydroxylases of the CYP153 family are common in alkane-degrading eubacteria lacking integral membrane alkane hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Vitamin D and vitamin D analogs in cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Insight into the redox partner interaction mechanism in cytochrome P450BM-3 using molecular dynamics simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Molecular evolution of a steroid hydroxylating cytochrome P450 using a versatile steroid detection system for screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Cluster screening: an effective approach for probing the substrate space of uncharacterized cytochrome P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Cloning, characterization and expression of the gene encoding cytochrome P-450sca-2 from Streptomyces carbophilus involved in production of pravastatin, a specific HMG-CoA reductase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Screening of a minimal enriched P450 BM3 mutant library for hydroxylation of cyclic and acyclic alkanes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

P450(BM3) (CYP102A1): connecting the dots.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Molecular Characterization of a Class I P450 Electron Transfer System from Novosphingobium aromaticivorans DSM12444

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Towards preparative scale steroid hydroxylation with cytochrome P450 monooxygenase CYP106A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Analysis of the interaction of a hybrid system consisting of bovine adrenodoxin reductase and flavodoxin from the cyanobacterium Anabaena PCC 7119.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

Cytochromes P450 as useful biocatalysts: addressing the limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-014-5767-7

10.1007/S00253-014-5767-7

21 January 2018

Identifiers

DOI

1 reference

PubMed ID

24848420

Dimensions Publication ID

31 August 2017

0 references

1 reference

PubMed ID

24848420