Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes. (Q37810229)

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16 January 2020

title

Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes (English)

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6

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Hans H. Maurer

4

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16 January 2020

author name string

Andy Zöllner

1

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16 January 2020

Daniela Buchheit

2

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16 January 2020

Markus R Meyer

3

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16 January 2020

Frank T Peters

5

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publication date

1 July 2010

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volume

2

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issue

7

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page(s)

1277-1290

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Cytochromes P450 as versatile biocatalysts

16 January 2020

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Total biosynthesis of hydrocortisone from a simple carbon source in yeast

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Efficient conversion of 11-deoxycortisol to cortisol (hydrocortisone) by recombinant fission yeast Schizosaccharomyces pombe.

21 January 2018

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Biotechnological synthesis of the designer drug metabolite 4'-hydroxymethyl-alpha-pyrrolidinohexanophenone in fission yeast heterologously expressing human cytochrome P450 2D6--a versatile alternative to multistep chemical synthesis

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On the organic solvent and thermostability of the biocatalytic redox system of Rhodococcus ruber DSM 44541.

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Synthesis of ethyl (R)-4-chloro-3-hydroxybutanoate with recombinant Escherichia coli cells expressing (S)-specific secondary alcohol dehydrogenase

21 January 2018

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Synthesis of (R)-1,3-butanediol by enantioselective oxidation using whole recombinant Escherichia coli cells expressing (S)-specific secondary alcohol dehydrogenase

21 January 2018

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Enantioselective reduction of carbonyl compounds by whole-cell biotransformation, combining a formate dehydrogenase and a (R)-specific alcohol dehydrogenase

21 January 2018

1 reference

Improved synthesis of chiral alcohols with Escherichia coli cells co-expressing pyridine nucleotide transhydrogenase, NADP+-dependent alcohol dehydrogenase and NAD+-dependent formate dehydrogenase

21 January 2018

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Overcoming the thermodynamic limitation in asymmetric hydrogen transfer reactions catalyzed by whole cells.

21 January 2018

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Engineering the Pichia pastoris methanol oxidation pathway for improved NADH regeneration during whole-cell biotransformation.

21 January 2018

1 reference

Biotransformation of benzaldehyde by Saccharomyces cerevisiae: characterization of the fermentation and toxicity effects of substrates and products.

21 January 2018

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Epoxide hydrolase activity of Streptomyces strains

21 January 2018

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Epoxide hydrolase-catalyzed resolution of ethyl 3-phenylglycidate using whole cells of Pseudomonas sp.

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Cloning of an epoxide hydrolase-encoding gene from Rhodotorula mucilaginosa and functional expression in Yarrowia lipolytica.

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Screening enantioselective epoxide hydrolase activities from marine microorganisms: detection of activities in Erythrobacter spp.

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Flavin-containing monooxygenases: mutations, disease and drug response

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Pharmacogenetics of phase I and phase II drug metabolism

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Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification

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Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

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Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily

21 January 2018

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Human UDP-glucuronosyltransferases: metabolism, expression, and disease

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A historical overview of the heterologous expression of mammalian UDP-glucuronosyltransferase isoforms over the past twenty years.

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Role of active metabolites in the use of opioids

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Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions

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21 January 2018

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21 January 2018

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NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of Ibuprofen ((+/-)-(R,S)-2-(4-isobutylphenyl) propanoic acid), its metabolites, and analogues

21 January 2018

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Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac

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21 January 2018

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21 January 2018

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Enzymatic production of bile Acid glucuronides used as analytical standards for liquid chromatography-mass spectrometry analyses

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21 January 2018

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Establishment of Salmonella strain expressing catalytically active human UDP-glucuronosyltransferase 1A1 (UGT1A1).

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21 January 2018

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21 January 2018

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21 January 2018

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Characterization of a Schizosaccharomyces pombe mutant deficient in UDP-galactose transport activity

21 January 2018

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A new approach on the purification of recombinant human soluble catechol-O-methyltransferase from an Escherichia coli extract using hydrophobic interaction chromatography.

21 January 2018

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Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.

21 January 2018

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Comparison of 2-aminophenol and 4-nitrophenol as in vitro probe substrates for the major human hepatic sulfotransferase, SULT1A1, demonstrates improved selectivity with 2-aminophenol.

21 January 2018

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21 January 2018

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Identification and phenotype characterization of two CYP3A haplotypes causing different enzymatic capacity in fetal livers

21 January 2018

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21 January 2018

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Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6

21 January 2018

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Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450

21 January 2018

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Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.

21 January 2018

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Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene

21 January 2018

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Improved cloning and expression of cytochrome P450s and cytochrome P450 reductase in yeast

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/BIO.10.80

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21083240%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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