Emerging therapeutic targets for osteoporosis treatment (Q38207147)

31 August 2017

title

Emerging therapeutic targets for osteoporosis treatment (English)

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31 August 2017

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Minglei Chen

1

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31 August 2017

Hongzhi Qiao

2

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31 August 2017

Zhigui Su

3

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31 August 2017

Huipeng Li

4

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31 August 2017

Qineng Ping

5

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31 August 2017

Li Zong

6

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31 August 2017

language of work or name

English

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publication date

25 April 2014

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Expert Opinion on Therapeutic Targets

31 August 2017

published in

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31 August 2017

volume

18

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31 August 2017

issue

7

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31 August 2017

page(s)

817-831

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Bone targeting for the treatment of osteoporosis

31 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Bone modeling and remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

New therapeutic targets for osteoporosis: beyond denosumab

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Emerging targets in osteoporosis disease modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Molecular biology of bone remodeling: implications for new therapeutic targets for osteoporosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Carbonic anhydrase II plays a major role in osteoclast differentiation and bone resorption by effecting the steady state intracellular pH and Ca2+

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Bone marrow transplantation corrects osteopetrosis in the carbonic anhydrase II deficiency syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Functions of RANKL/RANK/OPG in bone modeling and remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

The calcineurin/nuclear factor of activated T cells signaling pathway regulates osteoclastogenesis in RAW264.7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

NFAT and Osterix cooperatively regulate bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Conditional inactivation of Blimp1 in adult mice promotes increased bone mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Blimp1-mediated repression of negative regulators is required for osteoclast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Gene therapy with human recombinant osteoprotegerin reverses established osteopenia in ovariectomized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Transplantation of mesenchymal stem cells overexpressing RANK-Fc or CXCR4 prevents bone loss in ovariectomized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Osteoclasts, integrins, and osteoporosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Osteoclasts express high levels of pp60c-src in association with intracellular membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Involvement of alpha(v)beta3 integrins in osteoclast function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

CLC-7: a potential therapeutic target for the treatment of osteoporosis and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

The role of chloride channels in osteoclasts: ClC-7 as a target for osteoporosis treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Bone density, strength, and formation in adult cathepsin K (-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Osteoclast-derived activity in the coupling of bone formation to resorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Sex hormones, their receptors and bone health

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

The mechanisms of estrogen regulation of bone resorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Discovery and therapeutic promise of selective androgen receptor modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Designing the ideal selective estrogen receptor modulator--an achievable goal?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Small interfering RNA knocks down the molecular target of alendronate, farnesyl pyrophosphate synthase, in osteoclast and osteoblast cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

PTH and PTHrP signaling in osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Molecular and cellular mechanisms of the anabolic effect of intermittent PTH

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Parathyroid hormone uses multiple mechanisms to arrest the cell cycle progression of osteoblastic cells from G1 to S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

PTHrP signaling targets cyclin D1 and induces osteoblastic cell growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

SOST is a target gene for PTH in bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Bone morphogenetic protein activities are enhanced by 3',5'-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Transcription factors controlling osteoblastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Transcriptional regulation of the human Runx2/Cbfa1 gene promoter by bone morphogenetic protein-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Thymoquinone accelerates osteoblast differentiation and activates bone morphogenetic protein-2 and ERK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

The insulin-like growth factor-I gene and osteoporosis: a critical appraisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

PKB/AKT: functional insights from genetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

The p53/IGF-1 receptor axis in the regulation of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Biology of insulin-like growth factors in development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Transforming growth factor-beta1 to the bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Regulation of RANKL-induced osteoclastogenesis by TGF-β through molecular interaction between Smad3 and Traf6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

The Wnt signaling pathway in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Wnt/beta-catenin signaling: components, mechanisms, and diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Regulation of osteoblastogenesis and bone mass by Wnt10b

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Wnt10b inhibits development of white and brown adipose tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

GSK-3beta controls osteogenesis through regulating Runx2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Semaphorins in bone development, homeostasis, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Control of bone resorption by semaphorin 4D is dependent on ovarian function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Suppression of bone formation by osteoclastic expression of semaphorin 4D

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Osteoprotection by semaphorin 3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Role of farnesoid X receptor (FXR) in the process of differentiation of bone marrow stromal cells into osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Does complement play a role in bone development and regeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Eph and ephrin interactions in bone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Hedgehog coordination of postnatal osteoclast and osteoblast activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

Induction of DC-STAMP by Alternative Activation and Downstream Signaling Mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.912632

10.1517/14728222.2014.912632

21 January 2018

Identifiers

DOI

1 reference

31 August 2017

1 reference