Epigenetics, the holy grail in the pathogenesis of systemic sclerosis (Q38205150)

31 August 2017

Epigenetics, the holy grail in the pathogenesis of systemic sclerosis (English)

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31 August 2017

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Nezam Altorok

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31 August 2017

Nawaf Almeshal

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2

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31 August 2017

Yongqing Wang

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3

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31 August 2017

Bashar Kahaleh

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4

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31 August 2017

16 April 2014

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31 August 2017

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31 August 2017

54

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31 August 2017

10

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31 August 2017

1759-1770

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Scleroderma: from cell and molecular mechanisms to disease models

31 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Epidemiology of systemic sclerosis.

21 January 2018

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https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

21 January 2018

Scleroderma epidemiology

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https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Epigenetics in the pathogenesis of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

The immunobiology of systemic sclerosis

21 January 2018

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https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Systemic sclerosis: a prototypic multisystem fibrotic disorder

21 January 2018

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https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Pathogenesis of systemic sclerosis: A vascular hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Review: evidence that systemic sclerosis is a vascular disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Connective tissue synthesis by scleroderma skin fibroblasts in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Role of transforming growth factor beta in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Systemic sclerosis: genetics and epigenetics

21 January 2018

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https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

The genetics of scleroderma (systemic sclerosis).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Association of a functional polymorphism in the IRF5 region with systemic sclerosis in a Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Primer: epigenetics of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Predictors of the scleroderma phenotype in fibroblasts from systemic sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Endothelial nitric oxide synthase: insight into cell-specific gene regulation in the vascular endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

DNA methylation and chromatin - unraveling the tangled web.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Gene body-specific methylation on the active X chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

DNA methylation: the nuts and bolts of repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Gene action in the X-chromosome of the mouse (Mus musculus L.)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

DNA demethylation of CD40l in CD4+ T cells from women with systemic sclerosis: a possible explanation for female susceptibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Demethylation of TNFSF7 contributes to CD70 overexpression in CD4+ T cells from patients with systemic sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Epigenetic regulation of vascular endothelial gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Control of microRNA biogenesis and transcription by cell signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Emerging complexity of microRNA generation cascades.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

The widespread regulation of microRNA biogenesis, function and decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Epigenetic regulation of normal human mammary cell type-specific miRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Non-cardiomyocyte microRNAs in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

MicroRNAs and the glomerulus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

MicroRNAs in liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Role of MicroRNAs in Fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

microRNA-7 down-regulation mediates excessive collagen expression in localized scleroderma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

MicroRNA expression abnormalities in limited cutaneous scleroderma and diffuse cutaneous scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

MicroRNA-29, a key regulator of collagen expression in systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

miR-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin β3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Circulating miR-142-3p levels in patients with systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

MicroRNAs and the regulation of fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Essential role of MeCP2 in the regulation of myofibroblast differentiation during pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

MicroRNA-21 in scleroderma fibrosis and its function in TGF-β-regulated fibrosis-related genes expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

The role of epigenetic mechanisms and processes in autoimmune disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Epigenetics: A New Bridge between Nutrition and Health

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Hypoxia induces a novel signature of chromatin modifications and global repression of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

Association between theIRF5rs2004640 functional polymorphism and systemic sclerosis: A new perspective for pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU155

10.1093/RHEUMATOLOGY/KEU155

21 January 2018

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DOI

1 reference

31 August 2017

1 reference