The centrality of mitochondria in the pathogenesis and treatment of Parkinson's disease (Q38202314)

2 July 2019

title

The centrality of mitochondria in the pathogenesis and treatment of Parkinson's disease (English)

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2 July 2019

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Angelique Camilleri

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2 July 2019

Neville Vassallo

series ordinal

2

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2 July 2019

publication date

7 April 2014

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2 July 2019

CNS Neuroscience & Therapeutics

published in

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2 July 2019

volume

20

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2 July 2019

page(s)

591-602

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2 July 2019

issue

7

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2 July 2019

Mitochondrial biology and Parkinson's disease

cites work

1 reference

Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms.

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Mitochondria in the aetiology and pathogenesis of Parkinson's disease

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Generation of reactive oxygen species by the mitochondrial electron transport chain

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Complex I deficiency in Parkinson's disease frontal cortex

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Re-evaluation of the dysfunction of mitochondrial respiratory chain in skeletal muscle of patients with Parkinson's disease.

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Deficiencies of NADH and succinate dehydrogenases in degenerative diseases and myopathies

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Altered dopamine metabolism and increased vulnerability to MPTP in mice with partial deficiency of mitochondrial complex I in dopamine neurons

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A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

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Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice.

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Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter.

21 January 2018

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Inhibition of mitochondrial respiration by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse brain in vivo

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1 reference

The MPTP model of Parkinson's disease

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Paraquat neurotoxicity is distinct from that of MPTP and rotenone.

21 January 2018

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Environmental risk factors and Parkinson's disease: a case-control study in Taiwan

21 January 2018

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Pesticides and Parkinson's disease--is there a link?

21 January 2018

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Involvement of nitric oxide in maneb- and paraquat-induced Parkinson's disease phenotype in mouse: is there any link with lipid peroxidation?

21 January 2018

1 reference

Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I).

21 January 2018

1 reference

Rotenone, paraquat, and Parkinson's disease

21 January 2018

1 reference

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

1 reference

Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats

21 January 2018

1 reference

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

21 January 2018

1 reference

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

21 January 2018

1 reference

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

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Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity

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The role of α-synuclein in neurotransmission and synaptic plasticity

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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Alpha-synuclein in Lewy bodies

21 January 2018

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

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alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

21 January 2018

1 reference

Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model

21 January 2018

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Mitochondrial α-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

21 January 2018

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Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy

21 January 2018

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

21 January 2018

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Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

21 January 2018

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Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein

21 January 2018

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Mice lacking alpha-synuclein are resistant to mitochondrial toxins

21 January 2018

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Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors

21 January 2018

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Functional mitochondria are required for alpha-synuclein toxicity in aging yeast.

21 January 2018

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Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

21 January 2018

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Mitochondrial association of alpha-synuclein causes oxidative stress

21 January 2018

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Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols.

21 January 2018

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Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells

21 January 2018

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Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

21 January 2018

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Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein

21 January 2018

1 reference

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

1 reference

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

Clinical features of LRRK2-associated Parkinson's disease in central Norway

21 January 2018

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LRRK2 in Parkinson's disease: protein domains and functional insights

21 January 2018

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

21 January 2018

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Apoptotic mechanisms in mutant LRRK2-mediated cell death

21 January 2018

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LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

21 January 2018

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Localization of LRRK2 to membranous and vesicular structures in mammalian brain

21 January 2018

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LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

21 January 2018

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Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

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Genetics of Parkinson disease: paradigm shifts and future prospects.

21 January 2018

1 reference

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

21 January 2018

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Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release

21 January 2018

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Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

21 January 2018

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Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair

21 January 2018

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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

21 January 2018

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Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts

21 January 2018

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Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

21 January 2018

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Parkin-induced mitophagy in the pathogenesis of Parkinson disease

21 January 2018

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Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

21 January 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c.

21 January 2018

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Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

21 January 2018

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Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

21 January 2018

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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

21 January 2018

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Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.

21 January 2018

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PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

21 January 2018

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Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

21 January 2018

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Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

21 January 2018

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Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells

21 January 2018

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PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons

21 January 2018

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21 January 2018

Parkin blushed by PINK1.

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

21 January 2018

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

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DJ-1 has a role in antioxidative stress to prevent cell death

21 January 2018

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Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1

21 January 2018

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DJ-1 null dopaminergic neuronal cells exhibit defects in mitochondrial function and structure: involvement of mitochondrial complex I assembly

21 January 2018

1 reference

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

21 January 2018

1 reference

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

21 January 2018

1 reference

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

21 January 2018

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The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

21 January 2018

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Mitochondrial localization of DJ-1 leads to enhanced neuroprotection

21 January 2018

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Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection

21 January 2018

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Retracted: DJ-1 Modulates α-Synuclein Aggregation State in a Cellular Model of Oxidative Stress: Relevance for Parkinson's Disease and Involvement of HSP70

21 January 2018

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DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

21 January 2018

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DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

21 January 2018

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Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders.

21 January 2018

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Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease

21 January 2018

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The cybrid model of sporadic Parkinson's disease

21 January 2018

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Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer

21 January 2018

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Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues

21 January 2018

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Mitochondrial gene therapy augments mitochondrial physiology in a Parkinson's disease cell model

21 January 2018

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Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

21 January 2018

1 reference

Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease

21 January 2018

1 reference

Clinical neuroprotection in Parkinson's disease - still waiting for the breakthrough

21 January 2018

1 reference

Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases

21 January 2018

1 reference

The creatine kinase/creatine connection to Alzheimer's disease: CK-inactivation, APP-CK complexes and focal creatine deposits

21 January 2018

1 reference

Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases

21 January 2018

1 reference

Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.

21 January 2018

1 reference

Creatine and cyclocreatine attenuate MPTP neurotoxicity.

21 January 2018

1 reference

Creatine supplementation improves dopaminergic cell survival and protects against MPP+ toxicity in an organotypic tissue culture system

21 January 2018

1 reference

A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease.

21 January 2018

1 reference

A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-month results

21 January 2018

1 reference

Design innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1.

21 January 2018

1 reference

Mediterranean diet and dementia of the Alzheimer type

21 January 2018

1 reference

Habitual intake of dietary flavonoids and risk of Parkinson disease

21 January 2018

1 reference

Nutraceutical antioxidants as novel neuroprotective agents

21 January 2018

1 reference

Polyphenolic phytochemicals--just antioxidants or much more?

21 January 2018

1 reference

A possible role for pi-stacking in the self-assembly of amyloid fibrils

21 January 2018

1 reference

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

21 January 2018

1 reference

Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice

21 January 2018

1 reference

Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration

21 January 2018

1 reference

Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.

21 January 2018

1 reference

Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease

21 January 2018

1 reference

Life span and locomotor activity modification by glucose and polyphenols in Drosophila melanogaster chronically exposed to oxidative stress-stimuli: implications in Parkinson's disease.

21 January 2018

1 reference

Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model

21 January 2018

1 reference

Myricetin attenuated MPP(+)-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23.5 cells.

21 January 2018

1 reference

MPTP toxicity in the mouse brain and vitamin E.

21 January 2018

1 reference

Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice

21 January 2018

1 reference

Delayed-onset ataxia in mice lacking alpha -tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress

21 January 2018

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Iron uncouples oxidative phosphorylation in brain mitochondria isolated from vitamin E-deficient rats

21 January 2018

1 reference

Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures.

21 January 2018

1 reference

Paraquat-induced apoptotic cell death in cerebellar granule cells

21 January 2018

1 reference

Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk.

21 January 2018

1 reference

Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis

21 January 2018

1 reference

Vitamin E therapy in Parkinson's disease

21 January 2018

1 reference

Biochemical, physiological and medical aspects of ubiquinone function

21 January 2018

1 reference

Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10.

21 January 2018

1 reference

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice.

21 January 2018

1 reference

Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

21 January 2018

1 reference

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

21 January 2018

1 reference

Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease.

21 January 2018

1 reference

Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases

21 January 2018

1 reference

Neuroprotective effects of creatine

21 January 2018

1 reference

Antioxidant properties of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone (idebenone).

21 January 2018

1 reference

Co-enzyme Q10 and idebenone use in Friedreich's ataxia

21 January 2018

1 reference

Idebenone induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells

21 January 2018

1 reference

Uric acid as radical scavenger and antioxidant in the heart.

21 January 2018

1 reference

Protection of midbrain dopaminergic neurons by the end-product of purine metabolism uric acid: potentiation by low-level depolarization.

21 January 2018

1 reference

Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease

21 January 2018

1 reference

Plasma urate and risk of Parkinson's disease

21 January 2018

1 reference

Urate as a predictor of the rate of clinical decline in Parkinson disease

21 January 2018

1 reference

Diet, urate, and Parkinson's disease risk in men.

21 January 2018

1 reference

Alcohol intake and risk of incident gout in men: a prospective study

21 January 2018

1 reference

Inhibitor design for monoamine oxidases

21 January 2018

1 reference

Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial

21 January 2018

1 reference

Monoamine oxidase B inhibitors for the treatment of Parkinson's disease: a review of symptomatic and potential disease-modifying effects

21 January 2018

1 reference

A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes

21 January 2018

1 reference

Discordant effects of rasagiline doses in Parkinson disease

21 January 2018

1 reference

Crystal structure of human monoamine oxidase B, a drug target enzyme monotopically inserted into the mitochondrial outer membrane

21 January 2018

1 reference

Explaining ADAGIO: a critical review of the biological basis for the clinical effects of rasagiline

21 January 2018

1 reference

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes

21 January 2018

1 reference

Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties

21 January 2018

1 reference

Is antioxidant potential of the mitochondrial targeted ubiquinone derivative MitoQ conserved in cells lacking mtDNA?

21 January 2018

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The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease.

21 January 2018

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Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model

21 January 2018

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Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.

21 January 2018

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Animal and human studies with the mitochondria-targeted antioxidant MitoQ.

21 January 2018

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A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

21 January 2018

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Selective targeting of an antioxidant to mitochondria

21 January 2018

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A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

21 January 2018

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Mitochondrially targeted vitamin E and vitamin E mitigate ethanol-mediated effects on cerebellar granule cell antioxidant defense systems

21 January 2018

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Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis

21 January 2018

1 reference

Mitochondria-targeted small molecule therapeutics and probes

21 January 2018

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Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity

21 January 2018

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SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery

21 January 2018

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Imaging of superoxide generation in the dopaminergic area of the brain in Parkinson's disease, using mito-TEMPO.

21 January 2018

1 reference

Cell-permeable, mitochondrial-targeted, peptide antioxidants

21 January 2018

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Development of mitochondria-targeted aromatic-cationic peptides for neurodegenerative diseases

21 January 2018

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Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines

21 January 2018

1 reference

Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury

21 January 2018

1 reference

Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity

21 January 2018

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Role of mitochondrial Ca2+ in the regulation of cellular energetics

21 January 2018

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Mitochondrial peroxiredoxin-5 as potential modulator of mitochondria-ER crosstalk in MPP+-induced cell death

21 January 2018

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Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity.

21 January 2018

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Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca(2+) transfer to sustain cell bioenergetics.

21 January 2018

1 reference

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

21 January 2018

1 reference

Modeling PD pathogenesis in mice: advantages of a chronic MPTP protocol

21 January 2018

1 reference

Tolerability of isradipine in early Parkinson's disease: a pilot dose escalation study

21 January 2018

1 reference

Phase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson's disease (STEADY-PD).

21 January 2018

1 reference

Mitochondria and neuronal survival

21 January 2018

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12 December 2020

Bromal-derived tetrahydro-beta-carbolines as neurotoxic agents: chemistry, impairment of the dopamine metabolism, and inhibitory effects on mitochondrial respiration

1 reference

12 December 2020

Parkin expression in the adult mouse brain

1 reference

12 December 2020

Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022

1 reference

12 December 2020

Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022.

1 reference

12 December 2020

Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants.

1 reference

12 December 2020

The endogeneous formation of highly chlorinated tetrahydro-beta-carbolines as a possible causative mechanism in idiopathic Parkinson's disease

1 reference

12 December 2020

Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease

1 reference

12 December 2020

Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice

1 reference

12 December 2020

A mitochondria-targeted vitamin E derivative decreases hepatic oxidative stress and inhibits fat deposition in mice

1 reference

12 December 2020

Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice

1 reference

12 December 2020

Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates

1 reference

12 December 2020

Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro

1 reference

12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

12 December 2020

Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+

1 reference

12 December 2020

Identifiers

DOI

10.1111/CNS.12264

1 reference

2 July 2019

PMCID

6493084

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2 July 2019

PubMed ID

24703487

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2 July 2019