Protective and toxic roles of dopamine in Parkinson's disease (Q38189127)

30 August 2017

Protective and toxic roles of dopamine in Parkinson's disease (English)

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30 August 2017

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Emanuele Ferrari

4

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Irmgard Paris

Irmgard Paris

2

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Fabio A Zucca

Fabio A Zucca

6

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Juan Segura-Aguilar

Juan Segura-Aguilar

1

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Luigi Zecca

5

Luigi Zecca

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30 August 2017

Patricia Muñoz

3

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PubMed ID

24548101

30 August 2017

language of work or name

English

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publication date

18 March 2014

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Journal of Neurochemistry

30 August 2017

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30 August 2017

129

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30 August 2017

6

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30 August 2017

898-915

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A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

30 August 2017

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On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: mitochondria damage, necrosis, and hydroxyl radical formation

21 January 2018

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cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties

21 January 2018

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Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

21 January 2018

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Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease

21 January 2018

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The function of α-synuclein

21 January 2018

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Kinetic and structural analysis of the early oxidation products of dopamine: analysis of the interactions with alpha-synuclein.

21 January 2018

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Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: implications for mitochondrial dysfunction in Parkinson disease

21 January 2018

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Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1

21 January 2018

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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

21 January 2018

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Intracellular chemical imaging of the developmental phases of human neuromelanin using synchrotron X-ray microspectroscopy.

21 January 2018

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

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Stages in the development of Parkinson's disease-related pathology

21 January 2018

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The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface

21 January 2018

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The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

21 January 2018

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The neuromelanin of the human substantia nigra.

21 January 2018

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Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA

21 January 2018

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Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development

21 January 2018

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

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Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones.

21 January 2018

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Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin.

21 January 2018

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Increased nigral iron content in postmortem parkinsonian brain.

21 January 2018

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Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

21 January 2018

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Behavioral effects of aminochrome and dopachrome injected in the rat substantia nigra.

21 January 2018

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Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor

21 January 2018

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Copper neurotoxicity in rat substantia nigra and striatum is dependent on DT-diaphorase inhibition

21 January 2018

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A molecular dynamics simulation-based interpretation of nuclear magnetic resonance multidimensional heteronuclear spectra of α-synuclein·dopamine adducts

21 January 2018

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Influence of neuromelanin on oxidative pathways within the human substantia nigra

21 January 2018

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Iron-binding characteristics of neuromelanin of the human substantia nigra.

21 January 2018

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Studies on Parkinson's Disease Including X-Ray Fluorescent Spectroscopy of Formalin Fixed Brain Tissue

21 January 2018

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Protein degradation pathways in Parkinson's disease: curse or blessing

21 January 2018

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Neuromelanins of human brain have soluble and insoluble components with dolichols attached to the melanic structure

21 January 2018

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Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges.

21 January 2018

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Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

21 January 2018

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Modifications of the iron-neuromelanin system in Parkinson's disease

21 January 2018

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Dolichol is the major lipid component of human substantia nigra neuromelanin.

21 January 2018

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Synthesis and structural characterization of soluble neuromelanin analogs provides important clues to its biosynthesis

21 January 2018

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On the nature of pigment granules in the cells of the locus coeruleus and substantia nigra.

21 January 2018

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Occurrence and distribution of 5-S-cysteinyl derivatives of dopamine, dopa and dopac in the brains of eight mammalian species.

21 January 2018

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Inhibition of VMAT-2 and DT-diaphorase induce cell death in a substantia nigra-derived cell line--an experimental cell model for dopamine toxicity studies

21 January 2018

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Characterization of reduced and oxidized dopamine and 3,4-dihydrophenylacetic acid, on brain mitochondrial electron transport chain activities

21 January 2018

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Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling

21 January 2018

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Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease

21 January 2018

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Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons

21 January 2018

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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

21 January 2018

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Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease

21 January 2018

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Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study

21 January 2018

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Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease

21 January 2018

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Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene.

21 January 2018

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Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

21 January 2018

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Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4.

21 January 2018

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A timeline for Parkinson's disease

21 January 2018

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Genetic causes of Parkinson's disease: UCHL-1.

21 January 2018

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Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

21 January 2018

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Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction

21 January 2018

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Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?

21 January 2018

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Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

21 January 2018

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Encapsulation of a reactive core in neuromelanin

21 January 2018

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Chemistry of mixed melanogenesis--pivotal roles of dopaquinone

21 January 2018

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Iron-melanin complex in substantia nigra of parkinsonian brains: an x-ray microanalysis

21 January 2018

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Chemical intermediates in dopamine oxidation by tyrosinase, and kinetic studies of the process.

21 January 2018

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Profound neuronal plasticity in response to inactivation of the dopamine transporter

21 January 2018

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Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations

21 January 2018

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α-Synuclein oligomers and clinical implications for Parkinson disease

21 January 2018

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Melanin affinity and its possible role in neurodegeneration

21 January 2018

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Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content?

21 January 2018

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

21 January 2018

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Interaction between chemicals and melanin

21 January 2018

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Dopamine covalently modifies and functionally inactivates parkin

21 January 2018

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Role of microtubules and actin filaments in the movement of mitochondria in the axons and dendrites of cultured hippocampal neurons

21 January 2018

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Neuromelanin and its possible protective and destructive properties

21 January 2018

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Stable expression of short interfering RNA for DT-diaphorase induces neurotoxicity.

21 January 2018

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Structures for amyloid fibrils

21 January 2018

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Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of L-dopa treatment

21 January 2018

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Alpha-synuclein and protein degradation pathways in Parkinson's disease: a pathological feed-back loop

21 January 2018

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Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

21 January 2018

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Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease

21 January 2018

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Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease.

21 January 2018

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α-Synuclein and mitochondrial dysfunction in Parkinson's disease

21 January 2018

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Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity

21 January 2018

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Oxidation chemistry of catecholamines and neuronal degeneration: an update

21 January 2018

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Myoglobin modification by enzyme-generated dopamine reactive species

21 January 2018

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Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.

21 January 2018

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Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line

21 January 2018

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Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra

21 January 2018

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Dopamine-dependent iron toxicity in cells derived from rat hypothalamus

21 January 2018

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Copper dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death

21 January 2018

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Aminochrome induces disruption of actin, alpha-, and beta-tubulin cytoskeleton networks in substantia-nigra-derived cell line

21 January 2018

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Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line

21 January 2018

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Chemical, pulse radiolysis and density functional studies of a new, labile 5,6-indolequinone and its semiquinone

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

21 January 2018

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Targeting alpha-synuclein for the treatment of Parkinson's disease

21 January 2018

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Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography

21 January 2018

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Neuromelanin inhibits enzymatic activity of 26S proteasome in human dopaminergic SH-SY5Y cells

21 January 2018

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Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome

21 January 2018

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Synthesis, redox properties, in vivo formation, and neurobehavioral effects of N-acetylcysteinyl conjugates of dopamine: possible metabolites of relevance to Parkinson's disease.

21 January 2018

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Cytotoxic and genotoxic potential of dopamine

21 January 2018

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Mitochondrial dysfunction and oxidative stress in Parkinson's disease

21 January 2018

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Intraneuronal dopamine-quinone synthesis: A review

21 January 2018

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Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.

21 January 2018

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Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

21 January 2018

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Neuroinflammation and oxidative stress: co-conspirators in the pathology of Parkinson's disease

21 January 2018

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Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection

21 January 2018

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"Subcellular proteomics" of neuromelanin granules isolated from the human brain

21 January 2018

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Advances in the genetics of Parkinson disease

21 January 2018

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Potential oxidative pathways of brain catecholamines

21 January 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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Proteomic analysis of rat brain mitochondria following exposure to dopamine quinone: implications for Parkinson disease.

21 January 2018

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Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells

21 January 2018

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The structure of neuromelanin as studied by chemical degradative methods

21 January 2018

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Quinoprotein adducts accumulate in the substantia nigra of aged rats and correlate with dopamine-induced toxicity in SH-SY5Y cells.

21 January 2018

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Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain.

21 January 2018

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Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease

21 January 2018

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Biochemistry and genetics of monoamine oxidase

21 January 2018

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Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter.

21 January 2018

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Tyrosinase mRNA is expressed in human substantia nigra.

21 January 2018

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The effect of a synthetic neuromelanin on yield of free hydroxyl radicals generated in model systems.

21 January 2018

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Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

21 January 2018

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Iron, brain ageing and neurodegenerative disorders

21 January 2018

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New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals

21 January 2018

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Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease

21 January 2018

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Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease

21 January 2018

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Human neuromelanin: an endogenous microglial activator for dopaminergic neuron death

21 January 2018

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Dopamine (DA) induced irreversible proteasome inhibition via DA derived quinones

21 January 2018

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Neuromelanin of the human substantia nigra: an update

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JNC.12686

1 reference

30 August 2017

1 reference

PubMed ID

24548101