Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. (Q36043724)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

0 references

0 references

1

1 reference

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27 January 2020

Antony J Cutler

4

1 reference

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27 January 2020

Mark Peakman

9

1 reference

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27 January 2020

Timothy Tree

12

1 reference

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27 January 2020

10

John A Todd

1 reference

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27 January 2020

author name string

Jennifer R Tyler

2

1 reference

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27 January 2020

Jennie H M Yang

3

1 reference

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27 January 2020

Kate Downes

5

1 reference

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27 January 2020

Marcin Pekalski

6

1 reference

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27 January 2020

Gwynneth L Bell

7

1 reference

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27 January 2020

Sarah Nutland

8

1 reference

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27 January 2020

Linda S Wicker

11

1 reference

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27 January 2020

language of work or name

English

0 references

publication date

28 March 2012

1 reference

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27 January 2020

published in

Journal of Immunology

1 reference

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27 January 2020

volume

188

1 reference

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27 January 2020

issue

9

1 reference

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27 January 2020

page(s)

4644-4653

1 reference

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An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells

27 January 2020

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Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.

2 October 2017

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A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study

2 October 2017

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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

2 October 2017

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2 October 2017

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

2 October 2017

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Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus

2 October 2017

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At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction

2 October 2017

1 reference

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Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

2 October 2017

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2 October 2017

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2 October 2017

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2 October 2017

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Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

2 October 2017

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23 September 2018

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23 September 2018

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23 September 2018

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Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

23 September 2018

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Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

23 September 2018

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23 September 2018

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23 September 2018

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Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function.

23 September 2018

1 reference

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CD4+CD25high regulatory cells in human peripheral blood

23 September 2018

1 reference

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Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22461703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Insulin-dependent diabetes mellitus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22461703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22461703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4049/JIMMUNOL.1100272

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json