Beyond E-cadherin: roles of other cadherin superfamily members in cancer (Q38179961)

30 August 2017

Beyond E-cadherin: roles of other cadherin superfamily members in cancer (English)

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30 August 2017

Frans van Roy

1

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PubMed ID

24442140

30 August 2017

language of work or name

English

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publication date

20 January 2014

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30 August 2017

Nature Reviews Cancer

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30 August 2017

14

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30 August 2017

121-134

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30 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrc3647

30 August 2017

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cites work

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21 January 2018

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Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

21 January 2018

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Involvement of members of the cadherin superfamily in cancer

21 January 2018

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Molecular evolution of the cadherin superfamily

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21 January 2018

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New insights into the evolution of metazoan cadherins

21 January 2018

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Regulatory networks defining EMT during cancer initiation and progression

21 January 2018

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Epithelial-mesenchymal transitions in development and disease

21 January 2018

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N-cadherin in neuroblastoma disease: expression and clinical significance

21 January 2018

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Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin

21 January 2018

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The fibroblast growth factor receptor acid box is essential for interactions with N-cadherin and all of the major isoforms of neural cell adhesion molecule

21 January 2018

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Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation

21 January 2018

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Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

21 January 2018

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N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation

21 January 2018

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Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression

21 January 2018

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A novel family of cyclic peptide antagonists suggests that N-cadherin specificity is determined by amino acids that flank the HAV motif

21 January 2018

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N-cadherin haploinsufficiency increases survival in a mouse model of pancreatic cancer

21 January 2018

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Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment

21 January 2018

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Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance

21 January 2018

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P-cadherin role in normal breast development and cancer

21 January 2018

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Homo- and heterotypic cell-cell contacts in Merkel cells and Merkel cell carcinomas: heterogeneity and indications for cadherin switching

21 January 2018

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P-cadherin promotes cell-cell adhesion and counteracts invasion in human melanoma

21 January 2018

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21 January 2018

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Cadherin switching and bladder cancer.

21 January 2018

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P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice.

21 January 2018

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P-cadherin expression in Merkel cell carcinomas is associated with prolonged recurrence-free survival.

21 January 2018

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P-cadherin in adhesion and invasion: opposite roles in colon and bladder carcinoma.

21 January 2018

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Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon

21 January 2018

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P-cadherin promotes liver metastasis and is associated with poor prognosis in colon cancer

21 January 2018

1 reference

Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells.

21 January 2018

1 reference

Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer.

21 January 2018

1 reference

P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model

21 January 2018

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P-cadherin is a direct PAX3-FOXO1A target involved in alveolar rhabdomyosarcoma aggressiveness.

21 January 2018

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Variation in cadherins and catenins expression is linked to both proliferation and transformation of Rhabdomyosarcoma

21 January 2018

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R-Cadherin expression inhibits myogenesis and induces myoblast transformation via Rac1 GTPase.

21 January 2018

1 reference

Loss of retinal cadherin facilitates mammary tumor progression and metastasis

21 January 2018

1 reference

Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer.

21 January 2018

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Cadherin-11 promotes the metastasis of prostate cancer cells to bone

21 January 2018

1 reference

Cadherin-11, a marker of the mesenchymal phenotype, regulates glioblastoma cell migration and survival in vivo

21 January 2018

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Overexpression of cadherins suppresses pulmonary metastasis of osteosarcoma in vivo

21 January 2018

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Epigenetic disruption of cadherin-11 in human cancer metastasis.

21 January 2018

1 reference

The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas

21 January 2018

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Endothelial cadherins and tumor angiogenesis.

21 January 2018

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Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments

21 January 2018

1 reference

VE-cadherin is a critical endothelial regulator of TGF-beta signalling

21 January 2018

1 reference

Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells

21 January 2018

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Integrin α2β1 mediates tyrosine phosphorylation of vascular endothelial cadherin induced by invasive breast cancer cells

21 January 2018

1 reference

Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma

21 January 2018

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Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signaling.

21 January 2018

1 reference

Interplay between neural-cadherin and vascular endothelial-cadherin in breast cancer progression

21 January 2018

1 reference

Desmosomes: new perpetrators in tumour suppression

21 January 2018

1 reference

Increased expression of Dsg2 in malignant skin carcinomas: A tissue-microarray based study

21 January 2018

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Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes

21 January 2018

1 reference

DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis

21 January 2018

1 reference

T-Cadherin is an auxiliary negative regulator of EGFR pathway activity in cutaneous squamous cell carcinoma: impact on cell motility

21 January 2018

1 reference

T-cadherin loss promotes experimental metastasis of squamous cell carcinoma.

21 January 2018

1 reference

Expression of Ksp-cadherin during kidney development and in renal cell carcinoma

21 January 2018

1 reference

CDH16/Ksp-cadherin is expressed in the developing thyroid gland and is strongly down-regulated in thyroid carcinomas

21 January 2018

1 reference

Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma

21 January 2018

1 reference

Cadherin-17 induces tumorigenesis and lymphatic metastasis in gastric cancer through activation of NFκB signaling pathway

21 January 2018

1 reference

Delta-protocadherins in health and disease.

21 January 2018

1 reference

Clustered protocadherins and neuronal diversity

21 January 2018

1 reference

Regulation of protocadherin gene expression by multiple neuron-restrictive silencer elements scattered in the gene cluster

21 January 2018

1 reference

REST in good times and bad: roles in tumor suppressor and oncogenic activities

21 January 2018

1 reference

Ubiquitination and deubiquitination of REST and its roles in cancers

21 January 2018

1 reference

The transcription factor REST is lost in aggressive breast cancer

21 January 2018

1 reference

Agglomerative epigenetic aberrations are a common event in human breast cancer

21 January 2018

1 reference

Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor

21 January 2018

1 reference

Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways.

21 January 2018

1 reference

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

21 January 2018

1 reference

Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma

21 January 2018

1 reference

Epigenetic silencing of the protocadherin family member PCDH-gamma-A11 in astrocytomas

21 January 2018

1 reference

Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival.

21 January 2018

1 reference

Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers

21 January 2018

1 reference

Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer.

21 January 2018

1 reference

Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma

21 January 2018

1 reference

Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance

21 January 2018

1 reference

Downregulation of PCDH9 predicts prognosis for patients with glioma.

21 January 2018

1 reference

Role of PCDH10 and its hypermethylation in human gastric cancer

21 January 2018

1 reference

Protocadherin 17 acts as a tumour suppressor inducing tumour cell apoptosis and autophagy, and is frequently methylated in gastric and colorectal cancers.

21 January 2018

1 reference

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

21 January 2018

1 reference

Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma.

21 January 2018

1 reference

Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma

21 January 2018

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Protocadherin8 is a functional tumor suppressor frequently inactivated by promoter methylation in nasopharyngeal carcinoma.

21 January 2018

1 reference

PCDH10 promoter hypermethylation is frequent in most histologic subtypes of mature lymphoid malignancies and occurs early in lymphomagenesis

21 January 2018

1 reference

Protocadherin PCDH10, involved in tumor progression, is a frequent and early target of promoter hypermethylation in cervical cancer.

21 January 2018

1 reference

Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies

21 January 2018

1 reference

Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer

21 January 2018

1 reference

Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation

21 January 2018

1 reference

PCDH10 is a candidate tumour suppressor gene in medulloblastoma.

21 January 2018

1 reference

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

21 January 2018

1 reference

PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer

21 January 2018

1 reference

The emergence of protocadherin-PC expression during the acquisition of apoptosis-resistance by prostate cancer cells

21 January 2018

1 reference

Cross modulation between the androgen receptor axis and protocadherin-PC in mediating neuroendocrine transdifferentiation and therapeutic resistance of prostate cancer

21 January 2018

1 reference

Protocadherin-PC promotes androgen-independent prostate cancer cell growth.

21 January 2018

1 reference

A human- and male-specific protocadherin that acts through the wnt signaling pathway to induce neuroendocrine transdifferentiation of prostate cancer cells.

21 January 2018

1 reference

Genes that mediate breast cancer metastasis to the brain

21 January 2018

1 reference

Protocadherin-7 induces bone metastasis of breast cancer

21 January 2018

1 reference

Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases

21 January 2018

1 reference

Paraxial protocadherin mediates cell sorting and tissue morphogenesis by regulating C-cadherin adhesion activity

21 January 2018

1 reference

A protocadherin-cadherin-FLRT3 complex controls cell adhesion and morphogenesis

21 January 2018

1 reference

Protocadherin-19 and N-cadherin interact to control cell movements during anterior neurulation

21 January 2018

1 reference

Contact-dependent promotion of cell migration by the OL-protocadherin-Nap1 interaction

21 January 2018

1 reference

Adhesion properties and retinofugal expression of chicken protocadherin-19.

21 January 2018

1 reference

Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits

21 January 2018

1 reference

The WASP-WAVE protein network: connecting the membrane to the cytoskeleton

21 January 2018

1 reference

WASP and WAVE family proteins: friends or foes in cancer invasion?

21 January 2018

1 reference

Cadherin-catenin adhesion complexes at the synapse

21 January 2018

1 reference

Identifying autism loci and genes by tracing recent shared ancestry

21 January 2018

1 reference

Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95

21 January 2018

1 reference

The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer

21 January 2018

1 reference

Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration

21 January 2018

1 reference

Sleeping giants: emerging roles for the fat cadherins in health and disease

21 January 2018

1 reference

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.

21 January 2018

1 reference

Identification of Fat4 as a candidate tumor suppressor gene in breast cancers

21 January 2018

1 reference

Cadherin defects in inherited human diseases

21 January 2018

1 reference

Cadherin-23 mediates heterotypic cell-cell adhesion between breast cancer epithelial cells and fibroblasts

21 January 2018

1 reference

Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells

21 January 2018

1 reference

E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer

21 January 2018

1 reference

Integrative genome-wide analysis reveals a robust genomic glioblastoma signature associated with copy number driving changes in gene expression.

21 January 2018

1 reference

High-resolution melting analysis of PCDH10 methylation levels in gastric, colorectal and pancreatic cancers.

21 January 2018

1 reference

Epigenetic inactivation of PCDH10 in human prostate cancer cell lines

21 January 2018

1 reference

Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers

21 January 2018

1 reference

Breast carcinomas that co-express E- and P-cadherin are associated with p120-catenin cytoplasmic localisation and poor patient survival

21 January 2018

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A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor

21 January 2018

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N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation

31 March 2020

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N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties

31 March 2020

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ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression

31 March 2020

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P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin

31 March 2020

1 reference

The predictive effect of cadherin-17 on lymph node micrometastasis in pN0 gastric cancer

31 March 2020

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Cadherin-17 interacts with α2β1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis.

31 March 2020

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Identification of 20 genes aberrantly methylated in human breast cancers

31 March 2020

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Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer

31 March 2020

1 reference

Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma

31 March 2020

1 reference

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

31 March 2020

1 reference

Characterizing the role of PCDH9 in the regulation of glioma cell apoptosis and invasion

31 March 2020

1 reference

Protocadherins: a large family of cadherin-related molecules in central nervous system

31 March 2020

1 reference

12 December 2020

Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone.

1 reference

12 December 2020

Epithelial E- and P-cadherins: role and clinical significance in cancer

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12 December 2020

Cadherin switching in human prostate cancer progression

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12 December 2020

E-cadherin's dark side: possible role in tumor progression

1 reference

12 December 2020

PCDH17 gene promoter demethylation and cell cycle arrest by genistein in gastric cancer

1 reference

12 December 2020

CDH11 expression is associated with survival in patients with osteosarcoma

1 reference

12 December 2020

Cadherin 13 in cancer.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3647

1 reference

PubMed ID

24442140

Dimensions Publication ID

30 August 2017

0 references

1 reference

PubMed ID

24442140