Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. (Q34324645)

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22 February 2020

title

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation (English)

1 reference

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22 February 2020

3

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22 February 2020

Logan A. Walsh

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22 February 2020

Sevin Turcan

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22 February 2020

Kasthuri Kannan

8

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22 February 2020

Ian Ganly

17

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22 February 2020

Linda Liau

18

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22 February 2020

author name string

Luc G T Morris

1

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22 February 2020

Andrew M Kaufman

2

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22 February 2020

Deepa Ramaswami

4

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22 February 2020

Stephanie Eng

7

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22 February 2020

Luke Peng

10

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22 February 2020

Victoria E Banuchi

11

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22 February 2020

Phillip Paty

12

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22 February 2020

Zhaoshi Zeng

13

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22 February 2020

Efsevia Vakiani

14

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22 February 2020

David Solit

15

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22 February 2020

Bhuvanesh Singh

16

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22 February 2020

Timothy C Cloughesy

19

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22 February 2020

Paul S Mischel

20

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22 February 2020

Ingo K Mellinghoff

21

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22 February 2020

Timothy A Chan

22

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22 February 2020

Yilong Zou

9

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22 February 2020

language of work or name

English

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publication date

27 January 2013

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22 February 2020

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22 February 2020

volume

45

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22 February 2020

page(s)

253-261

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22 February 2020

issue

3

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describes a project that uses

22 February 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/ng.2538

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

6 July 2018

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Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

6 July 2018

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The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

6 July 2018

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Identification of MYCBP as a beta-catenin/LEF-1 target using DNA microarray analysis

6 July 2018

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New insights into Fat cadherins

6 July 2018

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Wnt signalling in stem cells and cancer

6 July 2018

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An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells

6 July 2018

1 reference

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Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation

6 July 2018

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Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact

6 July 2018

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The fat-like gene of Drosophila is the true orthologue of vertebrate fat cadherins and is involved in the formation of tubular organs.

6 July 2018

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Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

6 July 2018

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The Wnt antagonist sFRP1 in colorectal tumorigenesis

6 July 2018

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6 July 2018

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Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin

6 July 2018

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beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system

6 July 2018

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Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.

6 July 2018

1 reference

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The Wnt signaling pathway and its role in tumor development

6 July 2018

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Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and beta-catenin

6 July 2018

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Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation

6 July 2018

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Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers

6 July 2018

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Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma

6 July 2018

1 reference

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E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

6 July 2018

1 reference

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Cadherin sequences that inhibit beta-catenin signaling: a study in yeast and mammalian cells

6 July 2018

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6 July 2018

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Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

6 July 2018

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Inhibition of beta-catenin-mediated transactivation by cadherin derivatives

6 July 2018

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Modulation of cell-cell adherens junctions by surface clustering of the N-cadherin cytoplasmic tail.

6 July 2018

1 reference

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Identification of c-MYC as a target of the APC pathway

6 July 2018

1 reference

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Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin

6 July 2018

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Consed: a graphical tool for sequence finishing

6 July 2018

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Beta-catenin mutations in cell lines established from human colorectal cancers

6 July 2018

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PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing

6 July 2018

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

6 July 2018

1 reference

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3729040

Functional interaction of beta-catenin with the transcription factor LEF-1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3729040

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3729040

Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3729040

Morphogenetic roles of classic cadherins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3729040

No evidence for mutations in the alpha- and beta-catenin genes in human gastric and breast carcinomas.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3729040

Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3729040

Structure and transcription of a human gene for H1 RNA, the RNA component of human RNase P.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3729040

The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3729040

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3729040

Deletion of chromosome 4q predicts outcome in stage II colon cancer patients.

6 July 2018

1 reference

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.

21 January 2018

1 reference

Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.

21 January 2018

1 reference

ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.

21 January 2018

1 reference

Comment on "The consensus coding sequences of human breast and colorectal cancers".

21 January 2018

1 reference

A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy.

21 January 2018

1 reference

Genomic mutation consequence calculator.

21 January 2018

1 reference

Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3729040

E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation

28 October 2018

1 reference

12 December 2020

Deletions in chromosome 4 differentially associated with the development of cervical cancer: evidence of slit2 as a candidate tumor suppressor gene

1 reference

12 December 2020

Frequent deletion of ING2 locus at 4q35.1 associates with advanced tumor stage in head and neck squamous cell carcinoma

1 reference

12 December 2020

The xCELLigence system for real-time and label-free monitoring of cell viability

1 reference

12 December 2020

Identifiers

DOI

10.1038/NG.2538

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23354438%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23354438%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23354438%20AND%20SRC:MED&resulttype=core&format=json