NF-κB pathways in hematological malignancies (Q38178074)

30 August 2017

NF-κB pathways in hematological malignancies (English)

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30 August 2017

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3

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30 August 2017

Giorgio Zauli

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author name string

Chiara Gasparini

series ordinal

1

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PubMed ID

24419302

30 August 2017

Claudio Celeghini

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2

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30 August 2017

14 January 2014

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Cellular and Molecular Life Sciences

30 August 2017

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30 August 2017

71

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30 August 2017

11

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30 August 2017

2083-2102

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https://scigraph.springernature.com/pub.10.1007/s00018-013-1545-4

30 August 2017

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cites work

Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

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12 December 2020

Activation of NF-kappaB by HTLV-I and implications for cell transformation

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12 December 2020

Emerging non-apoptotic functions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L.

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12 December 2020

Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2).

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12 December 2020

Triggering of CD40 antigen inhibits fludarabine-induced apoptosis in B chronic lymphocytic leukemia cells.

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12 December 2020

NF-kappaB and the regulation of hematopoiesis

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12 December 2020

B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2.

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12 December 2020

Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis.

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12 December 2020

Nuclear factor-κB, p53, and mitochondria: regulation of cellular metabolism and the Warburg effect

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12 December 2020

Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line

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12 December 2020

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor

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12 December 2020

TRAF1 is involved in the classical NF-kappaB activation and CD30-induced alternative activity in Hodgkin's lymphoma cells

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12 December 2020

Multifocal defects in immune responses in RelB-deficient mice.

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12 December 2020

NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses

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12 December 2020

RelB-dependent stromal cells promote T-cell leukemogenesis

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12 December 2020

Pathogenesis of human B cell lymphomas

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12 December 2020

The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia

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12 December 2020

IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice

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12 December 2020

Tumor-necrosis-factor-related apoptosis-inducing ligand and the regulation of hematopoiesis

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12 December 2020

Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

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12 December 2020

The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

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12 December 2020

Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.

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12 December 2020

Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells

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12 December 2020

Deciphering the pathway from the TCR to NF-kappaB

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12 December 2020

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12 December 2020

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

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12 December 2020

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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12 December 2020

Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

1 reference

12 December 2020

Leukaemias into the 21st century. Part 2: the chronic leukaemias

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12 December 2020

RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells

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12 December 2020

RelB forms transcriptionally inactive complexes with RelA/p65.

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12 December 2020

A noncanonical Flt3ITD/NF-κB signaling pathway represses DAPK1 in acute myeloid leukemia

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12 December 2020

The IKK2/NF-{kappa}B pathway suppresses MYC-induced lymphomagenesis.

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12 December 2020

Frequent engagement of RelB activation is critical for cell survival in multiple myeloma

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12 December 2020

Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas

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12 December 2020

Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma

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12 December 2020

Transcriptional cross talk between NF-kappaB and p53.

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12 December 2020

c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells

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12 December 2020

A structural basis for selective dimerization by NF-κB RelB

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12 December 2020

Recent advances in the therapeutic perspectives of Nutlin-3.

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12 December 2020

Inflammation meets cancer, with NF-κB as the matchmaker

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12 December 2020

Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival

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12 December 2020

Non-canonical NF-κB signaling pathway

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12 December 2020

Interactions of the Hdm2/p53 and proteasome pathways may enhance the antitumor activity of bortezomib

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12 December 2020

Developments in the immunophenotypic analysis of haematological malignancies.

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12 December 2020

Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines

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12 December 2020

Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts

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12 December 2020

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

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12 December 2020

Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.

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12 December 2020

Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit

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12 December 2020

Targeting pathological B cell receptor signalling in lymphoid malignancies

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12 December 2020

The NF-kappa B family member RelB is required for innate and adaptive immunity to Toxoplasma gondii

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12 December 2020

Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB

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12 December 2020

NF-κB subunit specificity in hemopoiesis.

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12 December 2020

Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kappa B-inducing kinase

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12 December 2020

Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.

1 reference

12 December 2020

Dendritic cell development and survival require distinct NF-kappaB subunits

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12 December 2020

Aptamer mediated siRNA delivery

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12 December 2020

Hallmarks of Cancer: The Next Generation

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12 December 2020

The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations

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12 December 2020

Leukaemias into the 21st century: part 1: the acute leukaemias

1 reference

12 December 2020

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12 December 2020

Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals

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12 December 2020

Lessons from next-generation sequencing analysis in hematological malignancies.

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12 December 2020

cAMP-induced NF-kappaB (p50/relB) binding to a c-myb intronic enhancer correlates with c-myb up-regulation and inhibition of erythroleukemia cell differentiation

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12 December 2020

NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome

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12 December 2020

Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism

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12 December 2020

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

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12 December 2020

p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy

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12 December 2020

Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells

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12 December 2020

Antitumor activity of bortezomib alone and in combination with TRAIL in human acute myeloid leukemia.

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12 December 2020

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

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12 December 2020

Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture

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12 December 2020

Cutting edge: B cell receptor signals regulate BLyS receptor levels in mature B cells and their immediate progenitors

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12 December 2020

The 2008 WHO classification of lymphomas: implications for clinical practice and translational research.

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12 December 2020

Limb and skin abnormalities in mice lacking IKKalpha

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12 December 2020

Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.

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12 December 2020

Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells.

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12 December 2020

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

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12 December 2020

p50-NF-kappaB complexes partially compensate for the absence of RelB: severely increased pathology in p50(-/-)relB(-/-) double-knockout mice

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12 December 2020

Role of full-length osteoprotegerin in tumor cell biology

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12 December 2020

NF-κB function in B lymphocytes

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12 December 2020

Classical and/or alternative NF-kappaB pathway activation in multiple myeloma

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12 December 2020

Pathogenesis of non-Hodgkin's lymphoma

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12 December 2020

TRAIL-based therapeutic approaches for the treatment of pediatric malignancies

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12 December 2020

A critical role for the NFkB pathway in multiple myeloma

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12 December 2020

STAT-3 activates NF-kappaB in chronic lymphocytic leukemia cells

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12 December 2020

Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts

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12 December 2020

CD40 ligand protects from TRAIL-induced apoptosis in follicular lymphomas through NF-kappaB activation and up-regulation of c-FLIP and Bcl-xL.

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12 December 2020

Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells

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12 December 2020

Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.

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12 December 2020

Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells

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12 December 2020

Control of lymphocyte development by nuclear factor-kappaB.

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12 December 2020

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

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12 December 2020

Two pathways to NF-kappaB.

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12 December 2020

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family

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12 December 2020

RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.

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12 December 2020

Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-κB (RelB/p50) in myeloma cells

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12 December 2020

Expression of relB is required for the development of thymic medulla and dendritic cells

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12 December 2020

Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers

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12 December 2020

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

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12 December 2020

Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma

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12 December 2020

p53 dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein

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12 December 2020

The MDM2 inhibitor Nutlin-3 modulates dendritic cell–induced T cell proliferation

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12 December 2020

CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis.

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12 December 2020

NF-kappaB RelB forms an intertwined homodimer

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12 December 2020

The MDM-2 antagonist nutlin-3 promotes the maturation of acute myeloid leukemic blasts

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12 December 2020

MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activity

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12 December 2020

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12 December 2020

Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines

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12 December 2020

Leveraging cancer genome information in hematologic malignancies

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12 December 2020

T cell receptor/CARMA1/NF-κB signaling controls T-helper (Th) 17 differentiation

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12 December 2020

Distinct motifs in the intracellular domain of human CD30 differentially activate canonical and alternative transcription factor NF-κB signaling

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12 December 2020

Signalling to drug resistance in CLL.

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12 December 2020

NF-κB as a target for modulating inflammatory responses

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12 December 2020

RANK-L and RANK: T cells, bone loss, and mammalian evolution

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12 December 2020

NF-kappaB in cancer: from innocent bystander to major culprit

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12 December 2020

Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer

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12 December 2020

RelB/p50 Dimers Are Differentially Regulated by Tumor Necrosis Factor-α and Lymphotoxin-β Receptor Activation

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12 December 2020

MDM2 antagonist Nutlin-3 enhances bortezomib-mediated mitochondrial apoptosis in TP53-mutated mantle cell lymphoma

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12 December 2020

Requirement for NF-kappaB in osteoclast and B-cell development

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12 December 2020

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

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12 December 2020

PI-3K/Akt and NF-?B/I?B? pathways are activated in Jurkat T cells in response to TRAIL treatment

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12 December 2020

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

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12 December 2020

Inefficient ZAP-70 phosphorylation and decreased thymic selection in vivo result from inhibition of NF-kappaB/Rel

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12 December 2020

Epidemiology of hematological malignancies

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12 December 2020

The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications

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12 December 2020

RelB inhibits cell proliferation and tumor growth through p53 transcriptional activation.

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12 December 2020

NF-kappaB in the pathogenesis and treatment of multiple myeloma

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12 December 2020

Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications

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12 December 2020

B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells

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12 December 2020

Mechanisms of Bcr-Abl-mediated NF-kappaB/Rel activation

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12 December 2020

The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects

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12 December 2020

Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls

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12 December 2020

Malignant pirates of the immune system

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12 December 2020

The follicular versus marginal zone B lymphocyte cell fate decision

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12 December 2020

The TRAIL apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary chronic lymphocytic leukemia cells

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12 December 2020

The two NF-kappaB activation pathways and their role in innate and adaptive immunity

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12 December 2020

p53 Attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts

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12 December 2020

Cancer-related inflammation

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12 December 2020

Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cells

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12 December 2020

CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells

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12 December 2020

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice

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12 December 2020

RelB, together with RelA, sustains cell survival and confers proteasome inhibitor sensitivity of chronic lymphocytic leukemia cells from bone marrow

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12 December 2020

Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1.

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12 December 2020

NF-κB: roles and regulation in different CD4(+) T-cell subsets

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12 December 2020

Transcriptional elongation of c-myb is regulated by NF-kappaB (p50/RelB).

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12 December 2020

Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells

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12 December 2020

Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

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12 December 2020

Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses

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12 December 2020

RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages

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12 December 2020

The MDM2 inhibitor Nutlins as an innovative therapeutic tool for the treatment of haematological malignancies

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12 December 2020

10.1007/S00018-013-1545-4

Identifiers

DOI

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30 August 2017

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PubMed ID

24419302