Significance of the anti-aging protein Klotho (Q38152465)

29 August 2017

Significance of the anti-aging protein Klotho (English)

1 reference

29 August 2017

Miribane Dërmaku-Sopjani

1

1 reference

29 August 2017

Selim Kolgeci

2

1 reference

29 August 2017

Sokol Abazi

3

1 reference

29 August 2017

Mentor Sopjani

4

1 reference

29 August 2017

14 October 2013

1 reference

Molecular Membrane Biology

29 August 2017

1 reference

29 August 2017

30

1 reference

29 August 2017

8

1 reference

29 August 2017

369-385

1 reference

Klotho prevents renal calcium loss.

29 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Novel mechanisms in the regulation of phosphorus homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

The regulation of renal phosphate transport

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Osteoporosis and adynamic bone in chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Inhibition of lung cancer cells growth, motility and induction of apoptosis by Klotho, a novel secreted Wnt antagonist, in a dose-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Downregulation of NaPi-IIa and NaPi-IIb Na-coupled phosphate transporters by coexpression of Klotho

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Increased inorganic phosphate induces human endothelial cell apoptosis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

FGF23 induces left ventricular hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

PKB/SGK-resistant GSK3 enhances phosphaturia and calciuria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Oxidative stress, DNA methylation and carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Fibroblast growth factor-23 is the phosphaturic factor in tumor-induced osteomalacia and may be phosphatonin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Regulation of phosphate transport by fibroblast growth factor 23 (FGF23): implications for disorders of phosphate metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Hyperphosphataemia and Hypocalcaemia Induced by Hypertonic Phosphate Enema - An Experimental Study and Review of the Literature

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Amelioration of progressive renal injury by genetic manipulation of Klotho gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho deficiency causes vascular calcification in chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho protein activates the PKC pathway in the kidney and testis and suppresses 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

alpha-Klotho as a regulator of calcium homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Evolution of the Fgf and Fgfr gene families

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

High dietary inorganic phosphate increases lung tumorigenesis and alters Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Role of Klotho in aging, phosphate metabolism, and CKD.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Accelerated suicidal erythrocyte death in Klotho-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Rapamycin-induced phosphaturia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Severely reduced production of klotho in human chronic renal failure kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Regulation of fibroblast growth factor-23 signaling by klotho

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Suppression of aging in mice by the hormone Klotho

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Liver-specific activities of FGF19 require Klotho beta

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Augmented Wnt signaling in a mammalian model of accelerated aging

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Pathogenic role of Fgf23 in Hyp mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Pathogenic role of Fgf23 in Dmp1-null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Role of microtubules in the rapid regulation of renal phosphate transport in response to acute alterations in dietary phosphate content

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho protein deficiency and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Regulation and function of the FGF23/klotho endocrine pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Oxidative stress decreases klotho expression in a mouse kidney cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Can features of phosphate toxicity appear in normophosphatemia?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Endothelial function in health and disease: new insights into the genesis of cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Intestinal phosphate transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Intestinal npt2b plays a major role in phosphate absorption and homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Plasma klotho and cardiovascular disease in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Plasma klotho and mortality risk in older community-dwelling adults

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-ĸB.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Genetic evidence of serum phosphate-independent functions of FGF-23 on bone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Regulation of the Na+/K+ ATPase by Klotho.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Stimulation of eryptosis by cadmium ions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho reduces apoptosis in experimental ischaemic acute renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney: DNA microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho: an antiaging protein involved in mineral and vitamin D metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho converts canonical FGF receptor into a specific receptor for FGF23

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Current understanding of klotho

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Regulation of oxidative stress by the anti-aging hormone klotho

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Dehydration: a new modulator of klotho expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

Anti-oxidative effect of Klotho on endothelial cells through cAMP activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09687688.2013.837518

10.3109/09687688.2013.837518

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference