Klotho: an antiaging protein involved in mineral and vitamin D metabolism (Q28291037)

Europe PubMed Central

title

Klotho: an antiaging protein involved in mineral and vitamin D metabolism (English)

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L Beck

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Gérard Friedlander

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G Friedlander

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author name string

P-Ureña Torres

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D Prié

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V Molina-Blétry

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C Silve

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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language of work or name

English

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publication date

April 2007

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published in

Kidney International

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volume

71

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issue

8

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page(s)

730-7

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Suppression of aging in mice by the hormone Klotho

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Regulation of fibroblast growth factor-23 signaling by klotho

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Sequence, structural, functional, and phylogenetic analyses of three glycosidase families

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Expression of Klotho protein in the inner ear.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Klotho protein activates the PKC pathway in the kidney and testis and suppresses 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Regulation of oxidative stress by the anti-aging hormone klotho

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Klotho converts canonical FGF receptor into a specific receptor for FGF23

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Severely reduced production of klotho in human chronic renal failure kidney.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Modulation of gene expression by moxonidine in rats with chronic renal failure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Klotho reduces apoptosis in experimental ischaemic acute renal failure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Molecular cloning and expression of a novel klotho-related protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Oxidative stress decreases klotho expression in a mouse kidney cell line.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Klotho protein promotes adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Klotho gene variation and expression in 20 inbred mouse strains.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

[Ageing, genetics and the somatotropic axis]

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Klotho protein protects against endothelial dysfunction.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Klotho-induced insulin resistance: a blessing in disguise?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Association of human aging with a functional variant of klotho

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Klotho gene polymorphisms associated with bone density of aged postmenopausal women

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Defect in parathyroid-hormone-induced luminal calcium absorption in connecting tubules of Klotho mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Regulation of stanniocalcin 1 and 2 expression in the kidney by klotho gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021

Upregulation of the klotho gene expression by thyroid hormone and during adipose differentiation in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002163

7 January 2021