Doxorubicin-induced death in tumour cells and cardiomyocytes: is autophagy the key to improving future clinical outcomes? (Q38150426)

29 August 2017

Doxorubicin-induced death in tumour cells and cardiomyocytes: is autophagy the key to improving future clinical outcomes? (English)

1 reference

29 August 2017

0 references

Oktay Tacar

1

1 reference

PubMed ID

24102557

29 August 2017

Crispin R Dass

series ordinal

2

1 reference

29 August 2017

18 September 2013

1 reference

Journal of Pharmacy and Pharmacology

29 August 2017

1 reference

29 August 2017

65

1 reference

29 August 2017

11

1 reference

29 August 2017

1577-1589

1 reference

Rules for making human tumor cells

29 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

DNA damage is an early event in doxorubicin-induced cardiac myocyte death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Activation of AMP-activated protein kinase contributes to doxorubicin-induced cell death and apoptosis in cultured myocardial H9c2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Differential effects of chemotherapeutic agents on the Bcl-2/Bax apoptosis pathway in human breast cancer cell line MCF-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Caspase inhibition switches doxorubicin-induced apoptosis to senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. intermediacy of H(2)O(2)- and p53-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

IkappaBalpha gene therapy in tumor necrosis factor-alpha- and chemotherapy-mediated apoptosis of hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Doxorubicin: the good, the bad and the ugly effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

The hepatic pharmacokinetics of doxorubicin and liposomal doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Pharmacogenetics of target genes across doxorubicin disposition pathway: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Review: doxorubicin delivery systems based on chitosan for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Mitochondrial DNA is a direct target of anti-cancer anthracycline drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Doxorubicin-induced apoptosis and chemosensitivity in hepatoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Apoptosis - the p53 network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

The first 30 years of p53: growing ever more complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Blinded by the Light: The Growing Complexity of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Awakening guardian angels: drugging the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Paradoxical suppression of cellular senescence by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Weak p53 permits senescence during cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Induction of cellular senescence by doxorubicin is associated with upregulated miR-375 and induction of autophagy in K562 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

p53 determines multidrug sensitivity of childhood neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Bcl-2 family members: dual regulators of apoptosis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Bcl-2 expression as a predictive marker of hormone-refractory prostate cancer treated with taxane-based chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Fas/FasL-dependent and -independent activation of caspase-8 in doxorubicin-treated human breast cancer MCF-7 cells: ADAM10 down-regulation activates Fas/FasL signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Life and death partners: apoptosis, autophagy and the cross-talk between them

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Self-eating and self-killing: crosstalk between autophagy and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Crosstalk between apoptosis and autophagy within the Beclin 1 interactome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Beclin 1 bridges autophagy, apoptosis and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Partial Beclin 1 silencing aggravates doxorubicin- and Fas-induced apoptosis in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Neuregulin-1 attenuates doxorubicin-induced autophagy in neonatal rat cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Induction of caspase-independent apoptosis in H9c2 cardiomyocytes by adriamycin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Is caspase-dependent apoptosis only cell differentiation taken to the extreme?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

The role of caspase-2 in stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

A tumor suppressor function for caspase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Induction of caspase-2 activation by a DNA enzyme evokes tumor cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Dz13, a c-jun DNAzyme, is a potent inducer of caspase-2 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Autophagy in ischemic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

21 January 2018

Identifiers

DOI

10.1111/JPHP.12144

1 reference

29 August 2017

1 reference

PubMed ID

24102557