Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin. (Q40709009)

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12 November 2019

title

Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin (English)

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12 November 2019

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Theocharis Panaretakis

1

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12 November 2019

Katja Pokrovskaja Tamm

2

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12 November 2019

author name string

Maria C Shoshan

3

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12 November 2019

Dan Grandér

4

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12 November 2019

publication date

21 August 2002

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Journal of Biological Chemistry

12 November 2019

language of work or name

English

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published in

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12 November 2019

volume

277

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12 November 2019

issue

46

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12 November 2019

page(s)

44317-44326

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A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

12 November 2019

cites work

1 reference

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Doxorubicin-induced apoptosis is associated with increased transcription of endothelial nitric-oxide synthase. Effect of antiapoptotic antioxidants and calcium

21 January 2018

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Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells.

21 January 2018

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Mitochondria as the central control point of apoptosis

21 January 2018

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Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

21 January 2018

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The mitochondrion in cell death control: certainties and incognita

21 January 2018

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

21 January 2018

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Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

21 January 2018

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Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis

21 January 2018

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Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteins

21 January 2018

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Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells

21 January 2018

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Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

21 January 2018

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Conformation of the Bax C-terminus regulates subcellular location and cell death

21 January 2018

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Cisplatin induces the proapoptotic conformation of Bak in a deltaMEKK1-dependent manner

21 January 2018

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A role for mitochondrial Bak in apoptotic response to anticancer drugs

21 January 2018

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

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The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

21 January 2018

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Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.

21 January 2018

1 reference

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N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death

21 January 2018

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Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

21 January 2018

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Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions

21 January 2018

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

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FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

21 January 2018

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Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients

21 January 2018

1 reference

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Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer

21 January 2018

1 reference

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Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells

21 January 2018

1 reference

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Cisplatin and UV radiation induce activation of the stress-activated protein kinase p38gamma in human melanoma cells

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M205273200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12193597%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

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