Hepatotoxicity: a scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action (Q38123214)

29 August 2017

Hepatotoxicity: a scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action (English)

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29 August 2017

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M Hewitt

1

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29 August 2017

S J Enoch

2

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29 August 2017

J C Madden

3

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29 August 2017

K R Przybylak

4

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29 August 2017

M T D Cronin

5

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29 August 2017

language of work or name

English

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publication date

1 August 2013

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Critical Reviews in Toxicology

29 August 2017

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29 August 2017

43

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29 August 2017

7

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29 August 2017

537-558

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Mechanisms of immune-mediated liver injury

29 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Cytochromes P450 and metabolism of xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Hepatotoxicity of antimicrobial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Mechanisms of the deleterious effects of tamoxifen on mitochondrial respiration rate and phosphorylation efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Cytosine arabinoside potentiates the apoptotic effect of bendamustine on several B- and T-cell leukemia/lymphoma cells and cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Catechol quinones of estrogens in the initiation of breast, prostate, and other human cancers: keynote lecture.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Drug-induced mitochondrial toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Extensive Ca2+ release from energized mitochondria induced by disulfiram

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Hemolysis of human erythrocytes induced by tamoxifen is related to disruption of membrane structure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

The effect of the anticancer drugs tamoxifen and hydroxytamoxifen on the calcium pump of isolated sarcoplasmic reticulum vesicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Regulation of hepatic blood flow: the hepatic arterial buffer response revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Hepatic toxicity of vitamin A and synthetic retinoids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Effects of entacapone and tolcapone on mitochondrial membrane potential

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Chlorpromazine induces apoptosis in activated human lymphoblasts: a mechanism supporting the induction of drug-induced lupus erythematosus?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Mechanisms of drug-induced liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Idiosyncratic drug-induced liver injury: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Mechanisms of hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Hepatotoxicity associated with dietary supplements containing anabolic steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

DNA polymerase gamma, the mitochondrial replicase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Prediction of drug-induced liver injury in humans by using in vitro methods: the case of ximelagatran

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Severe hepatotoxicity and probable hepatorenal syndrome associated with sulfadiazine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

In vitro metabolism of acitretin by human liver microsomes: evidence of an acitretinoyl-coenzyme A thioester conjugate in the transesterification to etretinate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Expression of the bile salt export pump is maintained after chronic cholestasis in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Recognizing drug-induced liver injury: current problems, possible solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Mitochondrial calcium and the permeability transition in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Subcutaneously administered apomorphine: pharmacokinetics and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

A review of the common properties of drugs with idiosyncratic hepatotoxicity and the "multiple determinant hypothesis" for the manifestation of idiosyncratic drug toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Influence of tamoxifen on gluconeogenesis and glycolysis in the perfused rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Slip and leak in mitochondrial oxidative phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

The development of structure-activity relationships for mitochondrial dysfunction: uncoupling of oxidative phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Effects of adriamycin on respiratory chain activities in mitochondria from rat liver, rat heart and bovine heart. Evidence for a preferential inhibition of complex III and IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

The effect of drugs on bile flow and composition. An overview

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Idoxifene derivatives are less reactive to DNA than tamoxifen derivatives, both chemically and in human and rat liver cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

In silico models for drug-induced liver injury--current status

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Protection from cytotoxic effects induced by the nitrogen mustard mechlorethamine on human bronchial epithelial cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Antiinflammatory action of glucocorticoids--new mechanisms for old drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Human carboxylesterases and their role in xenobiotic and endobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Anabolic-androgenic steroids and liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Why drugs fail--a study on side effects in new chemical entities.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

A large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

57 Mitochondrial electron-transport inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Role of reactive metabolites in drug-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Review of liver injury associated with dietary supplements

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Role of metabolism in drug-induced idiosyncratic hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

The respiratory-chain NADH dehydrogenase (complex I) of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Mitochondrial injury by disulfiram: two different mechanisms of the mitochondrial permeability transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

FDA-approved drug labeling for the study of drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

10.3109/10408444.2013.811215

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference