Recent advances in understanding the molecular pathogenesis of myelodysplastic syndromes (Q38122703)

29 August 2017

Recent advances in understanding the molecular pathogenesis of myelodysplastic syndromes (English)

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29 August 2017

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Austin G Kulasekararaj

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1

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29 August 2017

Azim M Mohamedali

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2

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29 August 2017

Ghulam J Mufti

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3

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29 August 2017

language of work or name

English

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publication date

19 July 2013

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British Journal of Haematology

29 August 2017

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29 August 2017

162

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29 August 2017

5

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29 August 2017

587-605

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Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

29 August 2017

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The most commonly reported variant in ASXL1 (c.1934dupG;p.Gly646TrpfsX12) is not a somatic alteration

21 January 2018

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ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

21 January 2018

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Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation

21 January 2018

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A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome

21 January 2018

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Clinical effect of point mutations in myelodysplastic syndromes

21 January 2018

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Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes

21 January 2018

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Acute myeloid leukemia with monosomal karyotype at the far end of the unfavorable prognostic spectrum

21 January 2018

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Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

21 January 2018

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Dnmt3a is essential for hematopoietic stem cell differentiation

21 January 2018

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The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases

21 January 2018

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Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation

21 January 2018

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Mutations of genes in the receptor tyrosine kinase (RTK)/RAS-BRAF signal transduction pathway in therapy-related myelodysplasia and acute myeloid leukemia

21 January 2018

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Significant correlation between the degree of WT1 expression and the International Prognostic Scoring System Score in patients with myelodysplastic syndromes.

21 January 2018

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Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

21 January 2018

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Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes.

21 January 2018

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SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias.

21 January 2018

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Asyn-anticonformational difference allows SRSF2 to recognize guanines and cytosines equally well

21 January 2018

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FLT3 mutations in myelodysplastic syndrome and chronic myelomonocytic leukemia

21 January 2018

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Five-group cytogenetic risk classification, monosomal karyotype, and outcome after hematopoietic cell transplantation for MDS or acute leukemia evolving from MDS.

21 January 2018

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Mutation in TET2 in myeloid cancers

21 January 2018

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Impact of genetic features on treatment decisions in AML.

21 January 2018

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250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies

21 January 2018

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Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin

21 January 2018

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

21 January 2018

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How to manage high-risk acute myeloid leukemia

21 January 2018

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Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family

21 January 2018

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Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia

21 January 2018

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Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia.

21 January 2018

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Refinement of the international prognostic scoring system (IPSS) by including LDH as an additional prognostic variable to improve risk assessment in patients with primary myelodysplastic syndromes (MDS).

21 January 2018

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Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML

21 January 2018

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Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms.

21 January 2018

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Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

21 January 2018

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Revised international prognostic scoring system for myelodysplastic syndromes

21 January 2018

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Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

21 January 2018

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Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

21 January 2018

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High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia

21 January 2018

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Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics

21 January 2018

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A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome

21 January 2018

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Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1

21 January 2018

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Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression

21 January 2018

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TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression.

21 January 2018

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Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms

21 January 2018

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Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

21 January 2018

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Histone ubiquitination: a tagging tail unfolds?

21 January 2018

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Topography, clinical, and genomic correlates of 5q myeloid malignancies revisited

21 January 2018

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Proposal for a new risk model in myelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System

21 January 2018

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Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia

21 January 2018

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

21 January 2018

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TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).

21 January 2018

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

21 January 2018

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TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis.

21 January 2018

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Acquired mutations in TET2 are common in myelodysplastic syndromes

21 January 2018

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EVI1 Impairs myelopoiesis by deregulation of PU.1 function

21 January 2018

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DNMT3A Mutations in Acute Myeloid Leukemia

21 January 2018

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Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome

21 January 2018

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Mutational analysis of the KIT gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia

21 January 2018

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TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).

21 January 2018

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Whole genome scanning as a cytogenetic tool in hematologic malignancies

21 January 2018

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FISH and SNP-A karyotyping in myelodysplastic syndromes: improving cytogenetic detection of del(5q), monosomy 7, del(7q), trisomy 8 and del(20q)

21 January 2018

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Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis

21 January 2018

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Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

21 January 2018

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Recurring mutations found by sequencing an acute myeloid leukemia genome

21 January 2018

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Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

21 January 2018

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SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)

21 January 2018

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TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study

21 January 2018

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Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome

21 January 2018

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Novel TET2 mutations associated with UPD4q24 in myelodysplastic syndrome.

21 January 2018

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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

21 January 2018

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

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Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

21 January 2018

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Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

21 January 2018

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Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms

21 January 2018

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Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

21 January 2018

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IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

21 January 2018

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Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

21 January 2018

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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

21 January 2018

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Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients

21 January 2018

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SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value

21 January 2018

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Recurrent SETBP1 mutations in atypical chronic myeloid leukemia

21 January 2018

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Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

21 January 2018

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New mechanisms of AML1 gene alteration in hematological malignancies

21 January 2018

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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

21 January 2018

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New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge

21 January 2018

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Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

21 January 2018

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Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms.

21 January 2018

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Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value

21 January 2018

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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

21 January 2018

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Spectrum of mutations in RARS-T patients includes TET2 and ASXL1 mutations

21 January 2018

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

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Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).

21 January 2018

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IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.

21 January 2018

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Rare occurrence of DNMT3A mutations in myelodysplastic syndromes

21 January 2018

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Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes

21 January 2018

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New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia

21 January 2018

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Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies

21 January 2018

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The Polycomb group protein EZH2 directly controls DNA methylation

21 January 2018

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ETV6 deletion is a common additional abnormality in patients with myelodysplastic syndromes or acute myeloid leukemia and monosomy 7.

21 January 2018

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Recurrent DNMT3A mutations in patients with myelodysplastic syndromes

21 January 2018

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Clonal architecture of secondary acute myeloid leukemia

21 January 2018

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SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

21 January 2018

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

21 January 2018

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The origin and evolution of mutations in acute myeloid leukemia

21 January 2018

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Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis

21 January 2018

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

21 January 2018

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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

21 January 2018

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Frequent pathway mutations of splicing machinery in myelodysplasia

21 January 2018

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EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia

21 January 2018

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Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia

21 January 2018

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The JAK2 V617F mutation is rare in RARS but common in RARS-T

21 January 2018

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The JAK2 V617F mutation identifies a subgroup of MDS patients with isolated deletion 5q and a proliferative bone marrow

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/BJH.12435

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29 August 2017

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