Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients (Q27851680)

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C A Hanson

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J M Hodnefield

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T L Lasho

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C M Finke

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R A Knudson

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R P Ketterling

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A Pardanani

An integrated genomic analysis of human glioblastoma multiforme

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publication date

January 2012

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published in

Leukemia

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volume

26

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issue

1

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page(s)

101-5

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cites work

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https://api.crossref.org/works/10.1038/LEU.2011.298

Recurring mutations found by sequencing an acute myeloid leukemia genome

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Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value

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IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.

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IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status

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Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia

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Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor

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The prognostic significance of IDH2 mutations in AML depends on the location of the mutation

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The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group

21 April 2017

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Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms

21 January 2018

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IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis.

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Recurrent IDH mutations in high-risk myelodysplastic syndrome or acute myeloid leukemia with isolated del(5q).

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IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia

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The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status

21 January 2018

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IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

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IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

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MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients

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Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates

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JAK2 germline genetic variation affects disease susceptibility in primary myelofibrosis regardless of V617F mutational status: nullizygosity for the JAK2 46/1 haplotype is associated with inferior survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.298

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.298

Isolated del(5q) in myeloid malignancies: clinicopathologic and molecular features in 143 consecutive patients.

21 January 2018

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IDH2 somatic mutations in chronic myeloid leukemia patients in blast crisis

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2011.298

The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.298

inferred from DOI database lookup

7 January 2021

based on heuristic

IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: clinical evidence for leukemogenic collaboration with JAK2V617F

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.298

inferred from DOI database lookup

7 January 2021

based on heuristic

Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.298

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/LEU.2011.298

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

3690021

1002085731

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3690021

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference