Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging (Q38121750)

29 August 2017

Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging (English)

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29 August 2017

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Chih-Hao Wang

1

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29 August 2017

Shi-Bei Wu

series ordinal

2

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29 August 2017

Yu-Ting Wu

series ordinal

3

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29 August 2017

Yau-Huei Wei

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4

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29 August 2017

1 May 2013

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Experimental Biology and Medicine

29 August 2017

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29 August 2017

238

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29 August 2017

450-460

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29 August 2017

5

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Mitochondria in health and disease: perspectives on a new mitochondrial biology

29 August 2017

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https://api.crossref.org/works/10.1177%2F1535370213493069

Human mitochondrial DNA: roles of inherited and somatic mutations

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213493069

Free radicals and antioxidants in normal physiological functions and human disease

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213493069

Mitochondria, oxidants, and aging

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213493069

Mitochondrial formation of reactive oxygen species

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213493069

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Aging: a theory based on free radical and radiation chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

The biologic clock: the mitochondria?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

The mitochondrial free radical theory of ageing--where do we stand?

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213493069

Response to the increase of oxidative stress and mutation of mitochondrial DNA in aging.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213493069

Taking a "good" look at free radicals in the aging process

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

The 4977 bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: a useful biomarker or more?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Mitochondrial DNA common deletion in the human eye: a relation with corneal aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Characteristics of cardiac aging in C57BL/6 mice.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213493069

Premature ageing in mice expressing defective mitochondrial DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Mitochondrial point mutations do not limit the natural lifespan of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Mitochondrial function and apoptotic susceptibility in aging skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Aging impairs skeletal muscle mitochondrial bioenergetic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Superoxide-driven aconitase FE-S center cycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Effects of calorie restriction on life span of microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Mitochondrial retrograde signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Ca2+ signaling, mitochondria and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Increased glycolysis in ageing cultured human diploid fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Metabolic control of resistance of human epithelial cells to H2O2 and NO stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Glucose metabolism and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

AMPKalpha1 regulates the antioxidant status of vascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

The many faces of insulin-like peptide signalling in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Calorie restriction, SIRT1 and metabolism: understanding longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Regulation of mitochondrial F(o)F(1)ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

SRT1720 improves survival and healthspan of obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Calorie restriction alters mitochondrial protein acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Mitochondrial sirtuins: regulators of protein acylation and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Distinct effects of calorie restriction and resveratrol on diet-induced obesity and Fatty liver formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Acetate metabolism and aging: An emerging connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Regulation of mammalian autophagy in physiology and pathophysiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Autophagy: process and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Rapamycin decelerates cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Induction of autophagy by spermidine promotes longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Autophagic cell death: the story of a misnomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Autophagy during cardiac stress: joys and frustrations of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

21 January 2018

The Beclin 1 interactome

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https://api.crossref.org/works/10.1177%2F1535370213493069

The Beclin 1 network regulates autophagy and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

FLIP-mediated autophagy regulation in cell death control

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Mitochondria and mitophagy: the yin and yang of cell death control

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Uth1p is involved in the autophagic degradation of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Mitophagy in yeast occurs through a selective mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

21 January 2018

Mechanisms of mitophagy

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Role of mitochondrial permeability transition pores in mitochondrial autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Autophagy fights disease through cellular self-digestion

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

21 January 2018

The genetics of ageing

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Autophagy in premature senescent cells is activated via AMPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Human Ageing Genomic Resources: integrated databases and tools for the biology and genetics of ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Caloric restriction delays disease onset and mortality in rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213493069

21 January 2018

Identifiers

DOI

10.1177/1535370213493069

1 reference

29 August 2017

1 reference