Cancer genome-sequencing study design (Q38099732)

28 August 2017

Cancer genome-sequencing study design (English)

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28 August 2017

Jill C Mwenifumbo

1

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PubMed ID

23594910

28 August 2017

Marco A Marra

series ordinal

2

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28 August 2017

1 May 2013

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28 August 2017

Nature Reviews Genetics

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28 August 2017

14

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28 August 2017

5

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28 August 2017

321-332

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https://scigraph.springernature.com/pub.10.1038/nrg3445

28 August 2017

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DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

31 March 2020

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Finishing the euchromatic sequence of the human genome

31 March 2020

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Initial sequencing and analysis of the human genome

31 March 2020

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

31 March 2020

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

31 March 2020

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

31 March 2020

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Mutational processes molding the genomes of 21 breast cancers

31 March 2020

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development

31 March 2020

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Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

31 March 2020

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Medulloblastomics: the end of the beginning

31 March 2020

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Advances in understanding cancer genomes through second-generation sequencing

31 March 2020

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Recurring mutations found by sequencing an acute myeloid leukemia genome

31 March 2020

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Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML.

31 March 2020

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Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

31 March 2020

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Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors

31 March 2020

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Genome remodelling in a basal-like breast cancer metastasis and xenograft

31 March 2020

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A comprehensive catalogue of somatic mutations from a human cancer genome

31 March 2020

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A small-cell lung cancer genome with complex signatures of tobacco exposure

31 March 2020

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The mutation spectrum revealed by paired genome sequences from a lung cancer patient

31 March 2020

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The diploid genome sequence of an individual human

31 March 2020

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The complete genome of an individual by massively parallel DNA sequencing

31 March 2020

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The diploid genome sequence of an Asian individual

31 March 2020

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Accurate whole human genome sequencing using reversible terminator chemistry

31 March 2020

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The characterization of twenty sequenced human genomes

31 March 2020

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Whole-genome analysis informs breast cancer response to aromatase inhibition

31 March 2020

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Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

31 March 2020

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The genomic complexity of primary human prostate cancer

31 March 2020

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Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

31 March 2020

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dbSNP: the NCBI database of genetic variation

31 March 2020

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Accurate and comprehensive sequencing of personal genomes

31 March 2020

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Tumour evolution inferred by single-cell sequencing

31 March 2020

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Whole genome sequencing of matched primary and metastatic acral melanomas

31 March 2020

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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

31 March 2020

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The patterns and dynamics of genomic instability in metastatic pancreatic cancer

31 March 2020

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BAP1 loss defines a new class of renal cell carcinoma

31 March 2020

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The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer

31 March 2020

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Complex landscapes of somatic rearrangement in human breast cancer genomes

31 March 2020

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Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer

31 March 2020

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Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes

31 March 2020

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Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

31 March 2020

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Comprehensive molecular characterization of human colon and rectal cancer

31 March 2020

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Paired-end mapping reveals extensive structural variation in the human genome

31 March 2020

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Challenges in studying genomic structural variant formation mechanisms: the short-read dilemma and beyond

31 March 2020

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ABySS: a parallel assembler for short read sequence data

31 March 2020

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Next-generation DNA sequencing of paired-end tags (PET) for transcriptome and genome analyses

31 March 2020

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Computational methods for discovering structural variation with next-generation sequencing

31 March 2020

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Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes

31 March 2020

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Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data

31 March 2020

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Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

31 March 2020

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Landscape of somatic retrotransposition in human cancers

31 March 2020

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Use of whole-genome sequencing to diagnose a cryptic fusion oncogene

31 March 2020

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Paired tumor and normal whole genome sequencing of metastatic olfactory neuroblastoma

31 March 2020

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Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data

31 March 2020

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Second generation sequencing of the mesothelioma tumor genome

31 March 2020

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High-resolution characterization of a hepatocellular carcinoma genome

31 March 2020

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Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability

31 March 2020

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Passenger deletions generate therapeutic vulnerabilities in cancer

31 March 2020

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The clonal and mutational evolution spectrum of primary triple-negative breast cancers

31 March 2020

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The life history of 21 breast cancers

31 March 2020

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Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

31 March 2020

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Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

31 March 2020

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SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

31 March 2020

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Initial genome sequencing and analysis of multiple myeloma

31 March 2020

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Frequent mutation of BAP1 in metastasizing uveal melanomas

31 March 2020

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Frequent pathway mutations of splicing machinery in myelodysplasia

31 March 2020

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Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

31 March 2020

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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

31 March 2020

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Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV

31 March 2020

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Detection of structural variants and indels within exome data

31 March 2020

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Sequence analysis of mutations and translocations across breast cancer subtypes

31 March 2020

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Fusion transcripts and transcribed retrotransposed loci discovered through comprehensive transcriptome analysis using Paired-End diTags (PETs)

31 March 2020

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Mapping and quantifying mammalian transcriptomes by RNA-Seq

31 March 2020

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Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia

31 March 2020

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Dissecting the genomic complexity underlying medulloblastoma

31 March 2020

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Comprehensive genomic characterization of squamous cell lung cancers

31 March 2020

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Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells

31 March 2020

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RNA-Seq: a revolutionary tool for transcriptomics

31 March 2020

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MuSiC: identifying mutational significance in cancer genomes

31 March 2020

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Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM.

31 March 2020

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Next-generation genomics: an integrative approach

31 March 2020

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

31 March 2020

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A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing.

31 March 2020

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Cancer epigenomics: DNA methylomes and histone-modification maps

31 March 2020

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High-resolution profiling of histone methylations in the human genome

31 March 2020

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Human DNA methylomes at base resolution show widespread epigenomic differences

31 March 2020

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A novel retinoblastoma therapy from genomic and epigenetic analyses

31 March 2020

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Association of age at diagnosis and genetic mutations in patients with neuroblastoma.

31 March 2020

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Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

31 March 2020

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Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target

31 March 2020

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Hallmarks of Cancer: The Next Generation

31 March 2020

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Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

31 March 2020

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Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

31 March 2020

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Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution

31 March 2020

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Adaptive molecular convergence: Molecular evolution versus molecular phylogenetics.

31 March 2020

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Melanoma genome sequencing reveals frequent PREX2 mutations

31 March 2020

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A "silent" polymorphism in the MDR1 gene changes substrate specificity

31 March 2020

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Synonymous mutations in CFTR exon 12 affect splicing and are not neutral in evolution.

31 March 2020

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Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

31 March 2020

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Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer

31 March 2020

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

31 March 2020

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Clonal architecture of secondary acute myeloid leukemia

31 March 2020

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Comparative lesion sequencing provides insights into tumor evolution

31 March 2020

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Statistical analysis of pathogenicity of somatic mutations in cancer

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG3445

1 reference

PubMed ID

23594910

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23594910