From soluble aβ to progressive aβ aggregation: could prion-like templated misfolding play a role? (Q38099070)

28 August 2017

From soluble aβ to progressive aβ aggregation: could prion-like templated misfolding play a role? (English)

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28 August 2017

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Yvonne S Eisele

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28 August 2017

1 May 2013

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28 August 2017

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28 August 2017

23

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28 August 2017

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28 August 2017

333-341

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Insights into prion strains and neurotoxicity

28 August 2017

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Probing the biology of Alzheimer's disease in mice

21 January 2018

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Inclusion-body myositis: a myodegenerative conformational disorder associated with Abeta, protein misfolding, and proteasome inhibition

21 January 2018

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Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy.

21 January 2018

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Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

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Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register

21 January 2018

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Cerebral amyloid angiopathy: a systematic review

21 January 2018

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Fluid biomarkers in Alzheimer disease

21 January 2018

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Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice

21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Neuropathological stageing of Alzheimer-related changes

21 January 2018

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Frequency of stages of Alzheimer-related lesions in different age categories

21 January 2018

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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21 January 2018

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Molecular basis for amyloid- polymorphism

21 January 2018

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Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

21 January 2018

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

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Classification and basic pathology of Alzheimer disease

21 January 2018

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Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation

21 January 2018

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Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis

21 January 2018

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The amyloid state of proteins in human diseases

21 January 2018

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Chemical and biophysical insights into the propagation of prion strains.

21 January 2018

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Oligomeric intermediates in amyloid formation: structure determination and mechanisms of toxicity

21 January 2018

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Alzheimer's disease market: hope deferred

21 January 2018

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Developing β-secretase inhibitors for treatment of Alzheimer's disease

21 January 2018

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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

21 January 2018

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Reanalysis of the first case of Alzheimer's disease.

21 January 2018

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Inclusion body myositis: review of recent literature

21 January 2018

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Trafficking and proteolytic processing of APP

21 January 2018

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The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

21 January 2018

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Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone

21 January 2018

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

21 January 2018

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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

21 January 2018

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

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Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders

21 January 2018

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Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

21 January 2018

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Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition

21 January 2018

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

21 January 2018

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3D structure of Alzheimer's amyloid-beta(1-42) fibrils

21 January 2018

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Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

21 January 2018

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Biochemistry and cell biology of tau protein in neurofibrillary degeneration

21 January 2018

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Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease

21 January 2018

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Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases

21 January 2018

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Auguste D and Alzheimer's disease.

21 January 2018

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

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Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

21 January 2018

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De novo induction of amyloid-β deposition in vivo.

21 January 2018

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Neurotoxicity of amyloid β-protein: synaptic and network dysfunction

21 January 2018

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A presenilin 1 mutation in the first case of Alzheimer's disease

21 January 2018

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Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

21 January 2018

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Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers

21 January 2018

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Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

21 January 2018

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Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

21 January 2018

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A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

21 January 2018

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

21 January 2018

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Prion-like spread of protein aggregates in neurodegeneration

21 January 2018

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Novel proteinaceous infectious particles cause scrapie

21 January 2018

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Cell biology. A unifying role for prions in neurodegenerative diseases

21 January 2018

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Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

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Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

21 January 2018

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The value of incomplete mouse models of Alzheimer's disease

21 January 2018

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

21 January 2018

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Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats

21 January 2018

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Amyloid beta-protein assembly and Alzheimer disease

21 January 2018

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Proteolytic degradation of amyloid β-protein

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures

21 January 2018

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Neurodegenerative diseases target large-scale human brain networks

21 January 2018

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Neuropathological alterations in Alzheimer disease

21 January 2018

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Purified and synthetic Alzheimer's amyloid beta (Aβ) prions

21 January 2018

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

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N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits.

21 January 2018

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The development of amyloid beta protein deposits in the aged brain.

21 January 2018

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Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling.

21 January 2018

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Solid-state NMR studies of amyloid fibril structure

21 January 2018

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Molecular structures of amyloid and prion fibrils: consensus versus controversy

21 January 2018

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Amyloid-beta42 is preferentially accumulated in muscle fibers of patients with sporadic inclusion-body myositis

21 January 2018

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Tau reduction prevents Abeta-induced defects in axonal transport.

21 January 2018

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Exogenous induction of cerebral beta-amyloidosis in betaAPP-transgenic mice.

21 January 2018

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A beta oligomers - a decade of discovery

21 January 2018

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The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.

21 January 2018

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Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease

21 January 2018

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Kinetics and thermodynamics of amyloid fibril assembly

21 January 2018

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When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease

21 January 2018

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γ-Secretase as a target for Alzheimer's disease

21 January 2018

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Beyond the prion principle

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/BPA.12049

1 reference

28 August 2017

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PubMed ID

23587139