The PIM family of serine/threonine kinases in cancer (Q38098139)

28 August 2017

The PIM family of serine/threonine kinases in cancer (English)

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28 August 2017

Carmen Blanco-Aparicio

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Carmen Blanco-Aparicio

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2

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Amancio Carnero

object named as

Amancio Carnero

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3

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author name string

Maja Narlik-Grassow

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1

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28 August 2017

10 April 2013

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Medicinal Research Reviews

28 August 2017

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28 August 2017

34

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28 August 2017

1

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28 August 2017

136-159

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PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

28 August 2017

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Developmental expression of pim kinases suggests functions also outside of the hematopoietic system.

21 January 2018

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For better or for worse: the role of Pim oncogenes in tumorigenesis

21 January 2018

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The PIM kinases in hematological cancers

21 January 2018

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Structure and substrate specificity of the Pim-1 kinase

21 January 2018

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Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

21 January 2018

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The essential role of PIM kinases in sarcoma growth and bone invasion

21 January 2018

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The serine/threonine kinase Pim-1

21 January 2018

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The survival kinases Akt and Pim as potential pharmacological targets

21 January 2018

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Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma.

21 January 2018

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The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines

21 January 2018

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Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

21 January 2018

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IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils

21 January 2018

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Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3.

21 January 2018

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Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation

21 January 2018

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Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells.

21 January 2018

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The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells.

21 January 2018

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Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma.

21 January 2018

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Cryptic promoter activity in the DNA sequence corresponding to the pim-1 5'-UTR

21 January 2018

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Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1

21 January 2018

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Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation.

21 January 2018

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The proto-oncogene Pim-1 is a target of miR-33a

21 January 2018

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Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway

21 January 2018

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Regulation of Pim-1 by Hsp90

21 January 2018

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Protein phosphatase 2A regulates the stability of Pim protein kinases

21 January 2018

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Negative regulation of Pim-1 protein kinase levels by the B56beta subunit of PP2A.

21 January 2018

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Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region

21 January 2018

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Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

21 January 2018

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Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice.

21 January 2018

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Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis.

21 January 2018

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Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc

21 January 2018

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High-throughput retroviral tagging to identify components of specific signaling pathways in cancer.

21 January 2018

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Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver

21 January 2018

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Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors

21 January 2018

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Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene

21 January 2018

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Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study

21 January 2018

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Microarray-based classification of diffuse large B-cell lymphoma

21 January 2018

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PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma.

21 January 2018

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Molecular diagnosis of Burkitt's lymphoma

21 January 2018

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PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma

21 January 2018

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Overexpression of Pim-1 in bladder cancer

21 January 2018

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A potential therapeutic target for FLT3-ITD AML: PIM1 kinase

21 January 2018

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PIM-1 kinase expression in adipocytic neoplasms: diagnostic and biological implications.

21 January 2018

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Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines

21 January 2018

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Overexpression of PIM-1 is a potential biomarker in prostate carcinoma

21 January 2018

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Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression

21 January 2018

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Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor.

21 January 2018

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Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma.

21 January 2018

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Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines.

21 January 2018

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Potential roles for the PIM1 kinase in human cancer - a molecular and therapeutic appraisal

21 January 2018

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PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins

21 January 2018

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Experimental models for the development of new medical treatments in prostate cancer

21 January 2018

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Modeling prostate cancer in mice: limitations and opportunities

21 January 2018

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Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity

21 January 2018

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Pim family kinases enhance tumor growth of prostate cancer cells

21 January 2018

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p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase

21 January 2018

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Transgenic mice for Cre-inducible overexpression of the oncogenes c-MYC and Pim-1 in multiple tissues.

21 January 2018

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Pim kinase-dependent inhibition of c-Myc degradation

21 January 2018

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Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells

21 January 2018

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Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

21 January 2018

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STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5.

21 January 2018

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Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity

21 January 2018

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Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)

21 January 2018

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Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus

21 January 2018

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Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase

21 January 2018

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Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus

21 January 2018

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Pim-1 associates with protein complexes necessary for mitosis

21 January 2018

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Pim-1 regulates RANKL-induced osteoclastogenesis via NF-κB activation and NFATc1 induction.

21 January 2018

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Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia

21 January 2018

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Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

21 January 2018

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Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells

21 January 2018

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Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

21 January 2018

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Regulation of Skp2 levels by the Pim-1 protein kinase

21 January 2018

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The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.

21 January 2018

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Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway

21 January 2018

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The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint

21 January 2018

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Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

21 January 2018

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The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

21 January 2018

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PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

21 January 2018

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PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis

21 January 2018

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PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.

21 January 2018

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Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

21 January 2018

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The Pim protein kinases regulate energy metabolism and cell growth

21 January 2018

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Targeted cancer therapy: what if the driver is just a messenger?

21 January 2018

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Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma

21 January 2018

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The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases.

21 January 2018

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Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

21 January 2018

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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

21 January 2018

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Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-like tyrosine kinase 3 and BCR/ABL.

21 January 2018

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The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes

21 January 2018

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Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders

21 January 2018

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Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells

21 January 2018

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Evidence that the Pim1 kinase gene is a direct target of HOXA9

21 January 2018

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KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA

21 January 2018

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KSHV encoded LANA upregulates Pim-1 and is a substrate for its kinase activity

21 January 2018

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Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity

21 January 2018

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Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus recruits uracil DNA glycosylase 2 at the terminal repeats and is important for latent persistence of the virus

21 January 2018

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Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma

21 January 2018

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DNA amplification on chromosome 6p12 in non small cell lung cancer detected by arbitrarily primed polymerase chain reaction.

21 January 2018

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Delineation of prognostic biomarkers in prostate cancer

21 January 2018

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Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

21 January 2018

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Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

21 January 2018

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Pim1 regulates androgen-dependent survival signaling in prostate cancer cells

21 January 2018

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Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.

21 January 2018

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Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma

21 January 2018

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Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status.

21 January 2018

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The Pim kinases control rapamycin-resistant T cell survival and activation

21 January 2018

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Pim-2 upregulation: biological implications associated with disease progression and perinueral invasion in prostate cancer

21 January 2018

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Roles of Pim-3, a novel survival kinase, in tumorigenesis

21 January 2018

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The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells

21 January 2018

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Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors

21 January 2018

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Pim kinase inhibitors: a survey of the patent literature

21 January 2018

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The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target FLT3-ITD AML cells.

21 January 2018

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Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis

21 January 2018

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Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

21 January 2018

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Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

21 January 2018

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Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases

21 January 2018

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Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

21 January 2018

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Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases

21 January 2018

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Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

21 January 2018

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Synthesis and SAR of inhibitors of protein kinase CK2: novel tricyclic quinoline analogs

21 January 2018

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Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors

21 January 2018

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Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase

21 January 2018

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Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound

21 January 2018

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Pim-3 is expressed in endothelial cells and promotes vascular tube formation.

21 January 2018

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Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration

21 January 2018

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NFAT proteins: emerging roles in cancer progression

21 January 2018

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Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair

21 January 2018

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The Pim kinases: new targets for drug development

21 January 2018

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Expression, purification, crystallization and preliminary crystallographic analysis of human Pim-1 kinase.

21 January 2018

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PIM kinase inhibitors downregulate STAT3(Tyr705) phosphorylation

21 January 2018

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The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms

21 January 2018

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Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells

21 January 2018

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Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737.

21 January 2018

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HDAC inhibitors induce cell cycle arrest, activate the apoptotic extrinsic pathway and synergize with a novel PIM inhibitor in Hodgkin lymphoma-derived cell lines.

21 January 2018

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Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma

21 January 2018

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Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program.

21 January 2018

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Pim-1 kinase inhibits pathological injury by promoting cardioprotective signaling.

21 January 2018

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Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair.

21 January 2018

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Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells

21 January 2018

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7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity

21 January 2018

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Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.21284

1 reference

28 August 2017

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PubMed ID

23576269